Conserved Protein Domain Family
SPRY_PRY_TRIM35
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cd12893: SPRY_PRY_TRIM35 
PRY/SPRY domain in tripartite motif-containing protein 35 (TRIM35)
This PRY/SPRY domain is found at the C-terminus of the overall domain architecture of tripartite motif 35, TRIM35 (also known as hemopoietic lineage switch protein), which includes a RING finger domain (RING) and a B-box motif (BBOX). TRIM35 may play a role as a tumor suppressor and is implicated in the cell death mechanism.
Links
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Statistics
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PSSM-Id: 293950
Aligned: 28 rows
Threshold Bit Score: 227.129
Created: 19-Jun-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9UPQ4       303 PFSFDPNTAAgwLSVSDDLTSVTNHgy--------rvQVENPERFSsaPCLLGSRVFsQGSHAWEVALGGlqsWRVGVVR 374 human
CAG12164     171 PVVVDPNTAAgcFVLSEDLTEVQNSsql-------fkLPDNPERFDisAEMLAAEGYsSGRHSWEVEVKEntyWVLGVAS 243 spotted green p...
AAI51917     301 PVILDPNTASpwLSISPDFSSMQESrer-------qsFPDNPERFDpcVFVLGSEGFsSGRHRWEVRVADhpkWILGVCK 373 zebrafish
CAF98050     265 PVVFDPNTASpwLSLDADLTAVKEShep-------liTPDNPERFDpcGFVLGAEGYtSGKHRWDVMVRDcpsWVVGVCK 337 spotted green p...
XP_001345530 287 PVVLDPNTAHpdLLVSADLSSVRWSwsk-------raLPDNAERFDhhPCVLASEGVrSGTLSWAVEVRQssdWTLGVTT 359 zebrafish
AAH95707     288 PVLLDRNTANskLCIEIDLDGVRMRpdwteeeiqreqLHRNPERFDhcPCVLGSVGFtTGMHKWDVDVKDntsWMVGIAI 367 zebrafish
AAH95803     291 PVILDPNTAHphLILSDDLTSVRESedk-------rqFPNNPERFDrfPCVLGSEGFrSGKHSWVVEVSYsfyWNLGVTT 363 zebrafish
CDR12532      49 PVVMDPNTASpwLSMSPDLASVRDSper-------qsLPDNPERFDpcVFVLGAEGFcSGKHRWEVHVGDnpkWILGICK 121 rainbow trout
XP_008322271 181 PVVLDPNTACpwLSLSDDLTSMKENtar-------ltVPDNPERFDpcVFVLGAEGYvSGKHKWEVLVGDnpkWMVGVCK 253 tongue sole
CDQ82210      38 PVTLDPNTAAscFILSEDLTVVQCCsqv-------fkLPNNPERFDisAELLGSEGFcSGRHSWEVEVKAntyWVVGVAS 110 rainbow trout

Q9UPQ4       375 VRQdsgaeghshscyhdTRSGFWYVCR-TQGVEGDhcvtsdpatSPLVLAi--pRRLRVELECEEGELSFYDAe-rHCHL 450 human
CAG12164     244 ESIsrkgk-----hvltPAEGFWTIRFrNGEHKACta-----pwEPLNMKrh-pDVIRIVLDMDRAKVTFYDPr-eRTPL 311 spotted green p...
AAI51917     374 ESVvrkrk-----ftvtTTAGVWTIGLsKGVYNALts-----prTVLNLErr-pETVRVKVNMEKGEVSFWDTg-nNKHL 441 zebrafish
CAF98050     338 EAVarkkk-----ftlsPSRGVWCIGLsKGVCTAFtn-----erMALQVQqr-lERIRIKLDMDKGEVSFWDGe-sATHL 405 spotted green p...
XP_001345530 360 ELNqrkg-------wdfFSADVWSVCYdEYSVSERp-------vFGVRVKqr-lERVRVDLDYDGGTISFSDAv-nNTHI 423 zebrafish
AAH95707     368 ESVqrka-------tsgIPAGVWCIGR-EGQVLSItdpq--ksqVPLCGFem-pKILRVTVNLDEGRLSFSDIe-cKTVY 435 zebrafish
AAH95803     364 ASNqrkg-------rdfYDTNVWSVEYyENPPQDSlns---tvsTCFTVTqk-lECVKVELDCDEGTVSFSDPa-tDTHL 431 zebrafish
CDR12532     122 ESVarkrk-----ftvsTDRGVWTIGLsKGVYSALtg-----qrTVLVVErr-pERIRVKLNMDKGEVSFWDAgngGKHL 190 rainbow trout
XP_008322271 254 ESVarkkk-----ftvsTNRGVWSVCHsKGVYTAStp-----erTELQLQsr-pKRIRVKLNIDKGEVSFWDGe-nDKHL 321 tongue sole
CDQ82210     111 ESInrkgk-----hvltPAEGFWTIRFrNGEHKACta-----pwAPLTMMrkepQVIRVVLDMDRGKVTFFDPr-eRTPL 179 rainbow trout

Q9UPQ4       451 YTFHARFG-EVRPYFYLggargagppEPLRICP 482 human
CAG12164     312 YTFTNIITpRAFPYFCSac-----keHPLKILP 339 spotted green pufferfish
AAI51917     442 CTFNDKFTgKLFPIFGPgl-----qsTPITILP 469 zebrafish
CAF98050     406 VTLQHNFNvKIFPFFGPgv-----hsTSMILVP 433 spotted green pufferfish
XP_001345530 424 HTFSSNFThTLIPFFSCyt------iFNLKILP 450 zebrafish
AAH95707     436 HTFTHSFTeKVFPFFCTes-----cdPSITILP 463 zebrafish
AAH95803     432 HTFTATFTdTVFPFFWGf--------SYQKILP 456 zebrafish
CDR12532     191 CTFTHKFTeRVFPIFGPgl-----htTPMEVNP 218 rainbow trout
XP_008322271 322 ITFTHKFNeKLFPIFGPgl-----hsEPMILLE 349 tongue sole
CDQ82210     180 YTFTDLISpRVFPYFCTac-----keHPLRLLP 207 rainbow trout
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