2JK9,3EMW,2FNJ,2V24,2IHS,3F2O,3EK9,2AFJ


Conserved Protein Domain Family
SPRY_SOCS1-2-4

?
cd12906: SPRY_SOCS1-2-4 
Click on image for an interactive view with Cn3D
SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
The SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. All four SPSB proteins interact with c-Met, the hepatocyte growth factor receptor, but only SPSB1, SPSB2, and SPSB4 interact with prostate apoptosis response protein 4 (Par-4). They are negative regulators that recruit the ECS E3 ubiquitin ligase complex to polyubiquitinate inducible nitric-oxide synthase (iNOS), resulting in its proteasomal degradation, thus contributing to protection against the cytotoxic effect of iNOS in activated macrophages. It has been shown that SPSB1 and SPSB4 induce the degradation of iNOS more strongly than SPSB2. The Drosophila melanogaster SPSB1 homolog, GUSTAVUS, interacts with the DEAD box RNA helicase Vasa. Suppressor of cytokine signaling (SOCS) proteins negatively regulate signaling from JAK-associated cytokine receptor complexes, and play key roles in the regulation of immune homeostasis.
Statistics
?
PSSM-Id: 293963
Aligned: 34 rows
Threshold Bit Score: 300.696
Created: 2-Jul-2012
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
peptide binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:2JK9: Human SPRY domain-containing SOCS box protein (SPSB1) binds prostate apoptosis response protein 4 (Par-4); contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                               # #                               #                 #    
2JK9_A        33 HSWNNNDRSlNVFVKEddkLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAmRQRGTHAVVGVATADAPLHSvGYTTLV 112 human
3EMW_A        44 HGWNPKDCSeNIEVKEg-gLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPlEQRGTHAVVGVATALAPLQTdHYAALL 122 human
XP_003728798  71 FAWNEEDRSlNIFVKDddpLTFHRHPVAQSTDCIRGKFGFSRGLHVFEVTWNsRQRGTHAVVGFATANAPLHCvGYQSLV 150 purple urchin
BAF75871      93 NTWSSVHKSiNINLLPsnpYTFHRNPVANSTDGIRGNRGYSEGIHIWEINWPlTMRGTHAVVGVSTEKCQLQQdRYVSLV 172 Dugesia ryukyue...
AFJ24733      62 YAWNPLDSSiNIDVKLidpLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKlRERGTHAVVGVCTKDAPLHChGYCSLI 141 Schmidtea medit...
CDP92301     169 YAWNPDDRSlNIFVKDddrLTFHRHPVAQSTDSIRAKIGFSKGFHVWQIKWPqRQRGTHASVGVATKAASLHAvGYTSLI 248 Brugia malayi
CDW54408      23 NAWNPNDCSvNIFVKEddcLTFHRHPVAQSTDGIRGKMGYSRGFHVWDVCWPtRQRGTHAVIGVATINAPIHTyGYCSLV 102 human whipworm
XP_006004754  55 NGWSPDDCSsNISIKEg-gHVLRRHPVAQSTDVARGRRGYSWGLHVWEITWLaEERGTHAVVGVATDQAPLQAeGYTALV 133 coelacanth
XP_005997991  51 NAWNAQDCSpNYIVKGdsqMTAHRLQVTQSTDCIRGRAGYSTGLHVWEISWPgAQRGSHAVVGVATAEAPLHSqSYQALV 130 coelacanth
3EK9_A        35 HGWNPKDCSeNIDVKEg-gLCFERRPVAQSTDGVRGKRGYSRGLHAWEISWPlEQRGTHAVVGVATALAPLQAdHYAALL 113 house mouse
Feature 1                                                                                        
2JK9_A       113 GNNHESWGWDLg-RNRLYHDGKn--qPSKTYPAflep------------detFIVPDSFLVALDMDDGTLSFIVDGQYMG 177 human
3EMW_A       123 GSNSESWGWDIg-RGKLYHQSKg--pGAPQYPAgtq-------------geqLEVPERLLVVLDMEEGTLGYAIGGTYLG 186 human
XP_003728798 151 GSNAESWGWDLg-RKKLFHDSKh--kTGHQYPLagh-------------sdnFNVPDTFQMILDMDEGTLSFSANDQFLG 214 purple urchin
BAF75871     173 GIDDESWGWDIvnRIKVHGKETgnpiCYEKYPDvkkirkm------csmgksFKIPSRIYLILDMYQGSLSFVIGNEFLG 246 Dugesia ryukyue...
AFJ24733     142 GLTEESWGWDIi-RKKLVHKQSvd-vEDQTYPViiaedicslgdaierpntnIEVQESIFVLLDMEEGTLSFINDGQYLG 219 Schmidtea medit...
CDP92301     249 GSNSESYGWDLi-RNKCYHDSKn--tSGWTYPKsill------------denHLAPDQFYCILDMDEGYMAFASDVDYYG 313 Brugia malayi
CDW54408     103 GSNPFSWGWDIg-RNKLYHDREh--lPSQPYPVvspd------------eptFMLPQDFFMVLDMDEGTLAFCTGTQYLG 167 human whipworm
XP_006004754 134 GSNSESWGWDIg-HCQLHHESKv--aPCCPYPArhgs------------eehIQVPDSFLVVLDMDEGTLGYSVNGQYLG 198 coelacanth
XP_005997991 131 GSNAESWGWELg-RNLCHHQSKk--qRGKVYPDspg--------------gpFQVPDTFSVVLDADEGTLSFLVDGEYLG 193 coelacanth
3EK9_A       114 GSNSESWGWDIg-RGKLYHQSKg--lEAPQYPAgpq-------------geqLVVPERLLVVLDMEEGTLGYSIGGTYLG 177 house mouse
Feature 1                         ###         
2JK9_A       178 VAFRGLKGKKLYPVVSAVWGHCEIRMRYL 206 human
3EMW_A       187 PAFRGLKGRTLYPAVSAVWGQCQVRIRYL 215 human
XP_003728798 215 IAFRGLKGKKLFPIVSAVWGHCEITLKYV 243 purple urchin
BAF75871     247 ICHMGLKGKTLYPTVSAVWGHCQVEIKYF 275 Dugesia ryukyuensis
AFJ24733     220 VAFSGLKGRTLYPAISAVWGHCEVTMAHL 248 Schmidtea mediterranea
CDP92301     314 VAFTGLKGRELFPVVSAVWGHCEITMKYL 342 Brugia malayi
CDW54408     168 VAFHSLKGKKLYPIVSAVWGHCEVTLKYV 196 human whipworm
XP_006004754 199 IAFRGLKGKKLYPAVSAVWGQCKVAIRYF 227 coelacanth
XP_005997991 194 PAFTGLKGKKLYPIISSVRGDSEVTIKYV 222 coelacanth
3EK9_A       178 PAFRGLKGRTLYPSVSAVWGQCQVRIRYM 206 house mouse

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap