?cl19756: I_LWEQ Superfamily (this model, PSSM-Id:302998 is obsolete)
I/LWEQ domain I/LWEQ domains bind to actin. It has been shown that the I/LWEQ domains from mouse talin and yeast Sla2p interact with F-actin. I/LWEQ domains can be placed into four major groups based on sequence similarity: (1) Metazoan talin; (2) Dictyostelium TalA/TalB and SLA110; (3) metazoan Hip1p and (4) yeast Sla2p. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",