1QUU,3F57,3EDV,3F57,3EDV,3FB2,3EDV,3FB2,3UUN,1OWA


Conserved Protein Domain Family
Spectrin

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pfam00435: Spectrin (this model, PSSM-Id:306853 is obsolete and has been replaced by 334073)
Click on image for an interactive view with Cn3D
Spectrin repeat
Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin and dystrophin. The sequence repeat used in this family is taken from the structural repeat in reference. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteristic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in ultiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.
Statistics
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PSSM-Id: 306853
View PSSM: pfam00435
Aligned: 80 rows
Threshold Bit Score: 43.0762
Threshold Setting Gi: 313104240
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1QUU_A  129 QLHLEFAKRAAPFNNWMEGAMEDL--QDMFI-VHSIEEIQSLIT---AHEQFKATLPEADGERQSIMaiqnEVEKVIqSY 202  human
P11532 1679 KHMETFDQNVDHITKWIIQADTLL--DESEK-----KKPQQKED---VLKRLKAELNDIRPKVDSTR----DQAANLmAN 1744 human
P11532 2580 KDSTQWLEAKEEAEQVLGQARAKLe-SWKEG-PYTVDAIQKKIT---ETKQLAKDLRQWQTNVDVAN----DLALKLlRD 2650 human
P11532 2934 ERLQELQEATDELDLKLRQAEVIKg-SWQPVgDLLIDSLQDHLE---KVKALRGEIAPLKENVSHVN----DLARQL-TT 3004 human
P11532 2104 EKWRRFHYDIKIFNQWLTEAEQFL------R-KTQIPENWEHAKykwYLKELQDGIGQRQTVVRTLN----ATGEEIiQQ 2172 human
P11532 1157 EKTVSLQKDLSEMHEWMTQAEEEY--LERDFeYKTPDELQKAVE---EMKRAKEEAQQKEAKVKLLT----ESVNSViAQ 1227 human
P11532  448 VLMDLQNQKLKELNDWLTKTEERTrkMEEEPlGPDLEDLKRQVQ---QHKVLQEDLEQEQVRVNSLT----HMVVVVdES 520  human
P11532 2211 NILSEFQRDLNEFVLWLEEADNIA--SIPLE-PGKEQQLKEKLE---QVKLLVEELPLRQGILKQLN----ETGGPVlVS 2280 human
P11532 1048 NKLRKIQNHIQTLKKWMAEVDVFL--KEEWPaLGDSEILKKQLK---QCRLLVSDIQTIQPSLNSVN----EGGQKIkNE 1118 human
P11532  830 NNIIAFYNQLQQLEQMTTTAENWL--KIQPTtPSEPTAIKSQLK---ICKDEVNRLSDLQPQIERLK----IQSIAL--K 898  human
1QUU_A  203 NIriSSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQE 240  human
P11532 1745 RG--DHCRKLVEPQISELNHRFAAISHRIKTGKASI-P 1779 human
P11532 2651 YS--ADDTRKVHMITENINASWRSIHKRVSEREAALEE 2686 human
P11532 3005 LG--IQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHE 3040 human
P11532 2173 SS--KTDASILQEKLGSLNLRWQEVCKQLSDRKKRL-E 2207 human
P11532 1228 AP--PVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1263 human
P11532  521 SG--DHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 556  human
P11532 2281 APisPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2318 human
P11532 1119 AE--PEFASRLETELKELNTQWDHMCQQVYARKEALKG 1154 human
P11532  899 EK--GQGPMFLDADFVAFTNHFKQVFSDVQAREKEL-Q 933  human
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