2II0,4JGW,4L9M


Conserved Protein Domain Family
RasGEF

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pfam00617: RasGEF (this model, PSSM-Id:306970 is obsolete and has been replaced by 395492)
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RasGEF domain
Guanine nucleotide exchange factor for Ras-like small GTPases.
Statistics
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PSSM-Id: 306970
View PSSM: pfam00617
Aligned: 703 rows
Threshold Bit Score: 38.695
Threshold Setting Gi: 123975942
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2II0_A        224 EIARQLTLLESDLY----RAVqpSELVGsvwtkedk--------------einspnllK-M-----------IR------ 267  human
Q55EC7        715 ELARQITIINSFYF----NRIkaREFIEyiwekcgeestttpyvgtsfvevvpaenihK-F-----------VR------ 772  Dictyostelium...
XP_003288460  692 ELARQITIINSIHF----NRIkgREFLEyiwekcrdeqspyv--gssfvdiipaenihS-F-----------VK------ 747  Dictyostelium...
EFA75400      587 ELARQFTIISGHNF----YQIqpREYLEicwerlsq---------------apspwvgSvLpnrpganihnfLD------ 641  Polysphondyli...
XP_001579527  254 ELARQITIFHSHIF----HNItpLELLAalwgnsec---------------ggcpniiR-L-----------QE------ 296  Trichomonas v...
XP_001321284  232 QIALQIALQDSLIF----GAIspRDVIAciggqlta---------------knspsisF-L-----------QE------ 274  Trichomonas v...
XP_001313049  233 QVALQIAYIDSIIF----QAVnpKDLMAmiggqisa---------------nscpsimY-L-----------HQ------ 275  Trichomonas v...
XP_011113665  389 HVAQQIHLFHKKYLtiwnPGT--DISLL--------------------------------------------MDvthalp 422  Dactylellina ...
EIE79200      192 RFAEQVYLFHLLQHtkykHEL--MNSLS------------------------------Ylprp------qtsVE------ 227  Rhizopus dele...
EPB83243     1040 SFAQQIYLFHLNKHkqyqKDL--MNPIS------------------------------Ylprp------qlsVQ------ 1075 Mucor circine...
2II0_A        268 --HTTNLT------LWFEKCIVETe-----------nLEERVAVVSRIIEILQvfqeL---NNFNGVLEVVSAMNSSPVY 325  human
Q55EC7        773 --KCNNLA------RFVSTEILKQt-----------kLQKRVATIERFIEAAEkclaN---NDYAAVFSIVEPLVDQSIE 830  Dictyostelium...
XP_003288460  748 --KCNDLS------RYVSTEVLKNt-----------qLQKRVATIERFIETADkllsH---YDYAGVFSIIEPLCDSSIE 805  Dictyostelium...
EFA75400      642 --HYDDLV------RFVSTEIVKHn-----------qVARRAATIERFIEAADkclsQ---SDFSSVFCIMQGLANPSVE 699  Polysphondyli...
XP_001579527  297 --HFDLLS------RFISHSIIFPa-----------tPKERANEFKRWFEVGQq---FeaqLNFNGLFSVICGITHRSVV 354  Trichomonas v...
XP_001321284  275 --HFDTLS------HFVAFSVIFEr-----------eVKVRATVYSMWVSILFelrkV---NDFCGMFSIYGGITHPSVE 332  Trichomonas v...
XP_001313049  276 --HFDALS------KFVAFSIIFEk-----------aAKERASIFAIWVEILLelnkV---NDFSGVFAVYNGITHPAVA 333  Trichomonas v...
XP_011113665  423 avHKNPLVftsnaiHFLGEKLCTDilmp------nhsHEFRASLLSHWIDVGRi---LqdlGDMVGWFAVIMAILSPAIL 493  Dactylellina ...
EIE79200      228 --MLNSLLfttaspHFLTKLIRNHilidsq-qqgsdgVLLRAQLLKHWIRVGTk---LhqlGDTTGWCAVAMGLCSVGIV 301  Rhizopus dele...
EPB83243     1076 --MLNSLLfttmapHFLTKLIRNQilidtqqqeadncMLVRSQLLEHWIRIGLe---LkelGDMTGWCAVAMGICSVGIV 1150 Mucor circine...
2II0_A        326 RLDHT----FEQIPsrqkkile--eahelseDHYKKY--------------------------LAKLRSIN--------- 364  human
Q55EC7        831 RLSDT----WRNVSqrnlatfehlksivskeNDHKKY--------------------------RELLPDAkpp------- 873  Dictyostelium...
XP_003288460  806 RLSET----WKNVSpkilslfeqlkslcskeNDHKKY--------------------------REALLDTkpp------- 848  Dictyostelium...
EFA75400      700 RLTDT----FKQLNsktnavyeqlktfvskeNDYKKY--------------------------REILQDAqap------- 742  Polysphondyli...
XP_001579527  355 RMEQTmkiaYKSINkkeldal---tdlceiaQDFKNY--------------------------RQRLQNTtdh------- 398  Trichomonas v...
XP_001321284  333 RLKSTieeaWKTMGpktkrefetiknicsfnNNFHGY--------------------------RQAVLIShpp------- 379  Trichomonas v...
XP_001313049  334 RLKTTnneaWKLISfrtkrefgsiqnitsfyNNFNAY--------------------------RQALLVRipp------- 380  Trichomonas v...
XP_011113665  494 RLQMT----WQMIE-----------------PSKLRTvveewvp-------------vmldleRRKFELNTaeavrpsvm 539  Dactylellina ...
EIE79200      302 RLKEA----WKSVE-----------------RDMVYTvqthwartlaehglfeqsiwtetwehETHFKFAQvl------- 353  Rhizopus dele...
EPB83243     1151 RLRET----WKAID-----------------RALVHQvqvewvnilteyglfsqimwaegwgdKSSLSQFSkvl------ 1203 Mucor circine...
2II0_A        365 ---------Ppc---vPFFG-IY--LTNI--------LKteegnpevlkrhgkelINFSK 401  human
Q55EC7        874 --------------ciPNIH-LL--LDEL--------SFietsspr---llpggiVNFFH 905  Dictyostelium discoideum
XP_003288460  849 --------------siPNIQ-LL--LDEL--------SFietsspr---llpggiVNFFH 880  Dictyostelium purpureum
EFA75400      743 --------------tiPHVR-LL--LDEL--------FFietsspk---llqggiVNFFH 774  Polysphondylium pallidum PN500
XP_001579527  399 --------------cvPFIG-CF--QKDL--------VYiqesyp----nkindlINFKK 429  Trichomonas vaginalis G3
XP_001321284  380 --------------cvPFFG-CF--QKDW--------VYfqem--------nefhTNDNK 406  Trichomonas vaginalis G3
XP_001313049  381 --------------lvPFMG-CF--QKDW--------VYfqe------------lnNFHP 403  Trichomonas vaginalis G3
XP_011113665  540 apgggaesiAvqd-iiPYFGdLChsLQETerr--------------------dnkINCKK 578  Dactylellina haptotyla CBS 200.50
EIE79200      354 --------hLdnpyclPFFGtIRqaVDRRrkhpkkslGPn--------------mINFEE 391  Rhizopus delemar RA 99-880
EPB83243     1204 ------sstAsdk-dlPFFGtIRqsVDRYrkhnkkllSPs--------------mVNFEE 1242 Mucor circinelloides f. circinell...
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