2L5S


Conserved Protein Domain Family
Activin_recp
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pfam01064: Activin_recp (this model, PSSM-Id:307282 is obsolete and has been replaced by 460048)
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Activin types I and II receptor domain
This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.
Links
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Statistics
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PSSM-Id: 307282
Aligned: 19 rows
Threshold Bit Score: 34.437
Created: 18-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2L5S_A          6 LQCF-------C----Hl---cTKDNFTCVt----dGLCFVSVTett------dkvIHNSMCIAEIDLiprdRPFVCAP- 60   human
Q24468         34 iECEhfd-ekmC----NttqqcETRIEHCKmeadkfPSCYVLWSvnett---gilrIKMKGCFT--------DMHECNQt 97   fruit fly
O35607         32 RLCAfkdpyqqdlgigesrishENGTILCSk----gSTCYGLWEkskg-----dinLVKQGCWSHIGDpqecHYEECVV- 101  house mouse
Q04771         33 YMCV-------C----Egl--sCGNEDHCEg-----qQCFSSLsind------gfhVYQKGCFQVYEQ----GKMTCKTp 84   human
O00238         30 LRCK-------C----HhhcpeDSVNNICSt----dGYCFTMIEedds-----glpVVTSGCLGLEG-----SDFQCRDt 84   human
Q9D7E5         28 LRCYtcsfakpC----DpvpreCREDEVCGvsvgtse-------------qkeeevIERKGCL---------PRAQCPLl 81   house mouse
Q7QGF7         42 LTCY-------C----EghcpgNLQNGTCEtr--pgGSCFVSVEavldeetkqlvpEYSHGCMSPEQGg---GLLQCKV- 104  Anopheles gam...
Q95SI0         15 LTCY-------C----DgscpdNVSNGTCEtr--pgGSCFSAVQqlydettgmyeeERTYGCMPPEDNg---GFLMCKV- 77   fruit fly
XP_019924632   31 LKCR-------Cspc-----hpNAVNDTCIa----kFQCFTGLRlvven--geqveIISKGCMSEEEn----SILQCKG- 87   Pacific oyster
AAB22240       49 rECIyynanweL----Ekt--nQSGVESCEgekdkrLHCYASWRnnsg-----fieLVKKGCWL--------DDFNCYDr 109  African clawe...

2L5S_A         61 --SSktg--svTT-TYCCn-QDHCNKIE 82   human
Q24468         98 ecVTsaeprqgNI-HFCCckGSRCNSNQ 124  fruit fly
O35607        102 --TTtppsiqnGTyRFCCcsTDLCNVNF 127  house mouse
Q04771         85 ps-------pgQA-VECCq-GDWCNRNI 103  human
O00238         85 pi------phqRRsIECCteRNECNKDL 106  human
Q9D7E5         82 ghATywsrsysLR-HQCCe-QDLCNAAA 107  house mouse
Q7QGF7        105 --GTvspqlhgKS-IVCCdnEDLCNQDL 129  Anopheles gambiae str. PEST
Q95SI0         78 --AAvph-lhgKN-IVCCdkEDFCNRDL 101  fruit fly
XP_019924632   88 --HLvph-rlpRT-VECCndEDYCNDFL 111  Pacific oyster
AAB22240      110 -qECiakeenpQV-FFCCceGNYCNKKF 135  African clawed frog
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