2O8F,2O8D


Conserved Protein Domain Family
MutS_I
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pfam01624: MutS_I (this model, PSSM-Id:307653 is obsolete and has been replaced by 426350)
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MutS domain I
This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.
Links
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Statistics
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PSSM-Id: 307653
Aligned: 57 rows
Threshold Bit Score: 98.0435
Created: 15-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2O8F_A      17 VGFVRFFQGMPEK-PTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKy------mGPAGAKnLQSVVLSKMNFESFV 89   human
O13396      13 HGFIRFYKSLPQL-GEEAIRIFDRGDWYTAHGDDATFIARTVYKTTSVIRq------lGRSDHTgLPSVTMTVTVFRQFL 85   Neurospora crass...
Q9XGC9      24 QGFISFFKKLPQ--DPRAVRLFDRRDYYTAHGENATFIARTYYHTMSALRq-------lGSSSDgILSASVSKAMFETIA 94   Zea mays
O24617      22 QGFLSFYKTLPN--DTRAVRFFDRKDYYTAHGENSVFIAKTYYHTTTALRq-------lGSGSNaLSSVSISRNMFETIA 92   thale cress
P25336     133 TPLDKQVKDLKMH-HRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKltidesnpQDCNHRqFAYCSFPDVRLNVHL 211  Saccharomyces ce...
Q38F29      38 TPLERQVVCLKESlPPDVILMVACGYRVKFYGRDSRVVSRRFGIMCI--------------QATpFEYSSVPYTGVNIYV 103  Trypanosoma brucei
P26359     104 TPLEQQYLELKKN-YQETILAIEVGYKFRFFGKDAKIASEVLGI--------------SCYFEHnFLNASVPSYRIDYHL 168  Schizosaccharomy...
O65607     105 TPLEQQVVELKSK-YPDVVLMVEVGYRYRFFGEDAEIAARVLGI--------------YAHMDHnFMTASVPTFRLNFHV 169  thale cress
P13705     188 TPLELQYLDMKQQ-HKDAVLCVECGYKYRFFGEDAEIAARELNI--------------YCHLDHnFMTASIPTHRLFVHV 252  house mouse
NP_998689   17 hGFLNFYFSMSDK-PDTTVRVFDRNDYYTVHGKDAIFAAKEVFKTNGVIKn-------LGSGNRrLESVVLSKMNFESFV 88   zebrafish

2O8F_A      90 KDLLL-VrQYRVEVYKNRAGNKAS--------K-------ENDWYLAYKASPGNLSQFE 132  human
O13396      86 REALF-KlGKRIEIWASPSG--------------------RMNWKVVKQASPGNLQDVE 123  Neurospora crassa OR74A
Q9XGC9      95 RNILLeRtDCTLELYEGS----------------------GSNWRLTKSGTPGNIGSFE 131  Zea mays
O24617      93 RDLLLeRnDHTVELYEGS----------------------GSNWRLVKTGSPGNIGSFE 129  thale cress
P25336     212 ERLVH-H-NLKVAVVEQAETSAIKkhdpgaskSs------VFERKISNVFTKATFGVNS 262  Saccharomyces cerevisiae S288c
Q38F29     104 RRLVA-M-GYRVAFADQE-SASIRsts--gnsKg------LFSREIGRVYSRGTMLPDe 151  Trypanosoma brucei
P26359     169 ERLIN-F-GLKVAVVRQTETAALK--------StsssrntLFDRRVARVLTKGTTLDDS 217  Schizosaccharomyces pombe 972h-
O65607     170 RRLVN-A-GYKIGVVKQTETAAIK--------ShganrtgPFFRGLSALYTKATLEAAE 218  thale cress
P13705     253 RRLVA-K-GYKVGVVKQTETAALK--------AigdnkssVFSRKLTALYTKSTLIGED 301  house mouse
NP_998689   89 RDLLL-VrQYRVEVYKNASKSSK-----------------EHDWQIAFKASPGNLTQFE 129  zebrafish
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