Conserved Protein Domain Family
Patched

?
pfam02460: Patched 
Patched family
The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Statistics
?
PSSM-Id: 308203
Aligned: 8 rows
Threshold Bit Score: 975.296
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q09938     52 LTLLDARKLYTPVSAP-SWKEEQVFSELWPVKSYEFLPERTFQWNRY--LYLVVHGRPYengtypNILEGSYLNDIAKIE 128  Caenorhabditis el...
Q18129     47 QTTNDPQYVFSPANAP-WRYERAVLTEHWPLDEEKFWPGKSYDLHGY--VDVIASGRIHpdygrpNILNIRYLDEVARIN 123  Caenorhabditis el...
Q19945     49 LRVDDPSYVFTPSDAR-WRREISVFNENWPLDENKFLPGKSFEAKRFvnILIRAKDGGS-------IMRDNVLHEIEILN 120  Caenorhabditis el...
O61894     44 IFSFGILNMRTEDDLR-FLYSPEHSLSREEYQVHKDFSGDSKNNSFV--SITIQTSSEDk-----NLLKKDLAQKLIQLN 115  Caenorhabditis el...
O44978     31 VLSSGLVHIRLEPDIRkAFSPDDSDAGYETRVWLEYYGLDIYPERAF--CIFTAKRENS------SILQEGALADIYTVD 102  Caenorhabditis el...
Q21883     44 FCSSKICFTKQEDDIKtGYTPVGARSLDEIEVFSDFFASTGDPIAVF--LFITAKDNSS-------MADYNTMKEVVDIM 114  Caenorhabditis el...
P91129     47 NPLSDAVYLFTPLGAQ-SKMERMSIHEKWPLTDNNYIPGRAVTQSRE--IQVTALARNDs-----NILDPKFANAVYQLD 118  Caenorhabditis el...
NP_493718  48 VLSLKIPFTRMQNDIS-DFTPFGARSRVELEKYRKFFNNHGEPKAIY--AFITSKVGDN-------MLGISQLNDTVHVL 117  Caenorhabditis el...
Q09938    129 EELVTNVsfpreaalednpalmrkrhlnetEIEENRn---ITITFKDVCMNW-YGDCYREKNVI---------------- 188  Caenorhabditis el...
Q18129    124 DYIIHNL-----------------------TVPVDIngkhYDIAYTDLCMRY-DWACYLNDHITmlmpktrwgnfsgpfa 179  Caenorhabditis el...
Q19945    121 QWIMNNI-----------------------SIPTDDl--kFNLTYQDLCLSY-DWVCGANEHIQm--------------- 159  Caenorhabditis el...
O61894    116 KYVLEKM-----------------------EIQVDGk---IINFGKEVCSRMkQCELSNTIATIfld-----------tf 158  Caenorhabditis el...
O44978    103 NRLSAAV-----------------------GYQDGD------G--RKNCDPLcDLNSPFHLLAN---------------- 135  Caenorhabditis el...
Q21883    115 DYVGSN-------------------------LTHKG------ESFYTLCTDFcQINEPVRQYYNgl-------------a 150  Caenorhabditis el...
P91129    119 KYIQTRV-----------------------RVLHNG----HYYSYKNLCLQYkNGGCPSNKHV----------------- 154  Caenorhabditis el...
NP_493718 118 DTISRDF-----------------------YLKTSQ----GPKNFEEYCSGFcLLNEPVKHFYSg--------------- 155  Caenorhabditis el...
Q09938    189 ELLKRRHElnkRGISVTFPQVNQEGTPIYIAFVIGGVDTYP-----------------------NDTIKYARAMRLWYFL 245  Caenorhabditis el...
Q18129    180 ELASDIIN---TQVNITYPIGWRGTEPIYFGALVGAPNLVDe----------------------EGHFDYASAIRLTYNT 234  Caenorhabditis el...
Q19945    160 lLRRNDVN---QILDLHFPRGGTKDTPVYLGGIFGDVQFFQ-----------------------NGTLSDAKLTQLFYFL 213  Caenorhabditis el...
O61894    159 WSEKLRKD---PRIKIEYPTMKFFDNKFFLPTHFYGVQPGGp----------------------LGIESIDMVHFVYQIP 213  Caenorhabditis el...
O44978    136 -LTRRNNG---TTSVFTYPDMPYSGLDIFLGLHLSNADFEP-----------------------PTERISSKSLVLWYFS 188  Caenorhabditis el...
Q21883    151 MKQQNLSEv-gSRFQLTFPMMQVLGKELDLSPNFFGVKTDE-----------------------DGNVEYVKIIMLQIRA 206  Caenorhabditis el...
P91129    155 HILSDLHN---HGFNITYPYFRFGSEGGYIGSSLGGVTVMKge-------------------neTDILASAKAWFMIYHL 212  Caenorhabditis el...
NP_493718 156 MLISGQHGtdfSHLDLGYPITTVLGTKLYMDPNFFGVKVTTsnnkvesiadgntklfgdhtkqePNNIREVSLVVLQFRS 235  Caenorhabditis el...
Q09938    246 KfdDEEQEQLAKFWEDTAEKFVRETYADHp-TIQCHIKHSRIVDQGLTRNANRLKPYFNVTIAVLVLFTAFYSVkwYFRM 324  Caenorhabditis el...
Q18129    235 R--EGKVDQYGIEWRRKLSMWLTDKENPVseLLEFGVNHNMTLPEGLQDVADTLAPKFVGTCAILFTFSFLVSV--VLRK 310  Caenorhabditis el...
Q19945    214 KqdQKMVEEYSSKFSYALETFLNQVYSSD--VITLSFAHYQSLEDGLDENAKAFVPNFVVSFFVLAMYALVSSF--TLKS 289  Caenorhabditis el...
O61894    214 AynEHTSEEMSKIFEQSLTALLENQTTFD-----TSMFSLSILKDEMQKNSTYTMPFISLTILLLLCFTVASCM--TDNW 286  Caenorhabditis el...
O44978    189 RsdTPEGKLAFKDAIDELFQLSKNSSAFE--HVQFTIFSDQVANREMIRGAIEATTLMTIGFFLLLTQVIIVIV--RLSS 264  Caenorhabditis el...
Q21883    207 NipNDWKKEDAAEYERMISQYFHFKYDST--HVTPLAMSLTYTGDEVVRTGLTIFPFIGVGFIIMTTFSIITIY--YSSS 282  Caenorhabditis el...
P91129    213 KfhPEEMSYISGEWELELGRMLTQYPEDP--YISITYFHSQTLADELKRNADTLIPRFIISITLLIVFSTLCSL--SFID 288  Caenorhabditis el...
NP_493718 236 ElgDEVTPEDLRNYEHQILDYIHDEYQSE--HINVYILTDSYITEEIVRAGLTLLPFLVIGFTIMAVFSSITFV--VSAY 311  Caenorhabditis el...
Q09938    325 dhswpLHIDWLRSKPMLALGGVLSSVLAILSGIGLLLWFGMFFAEITLIAPFLVLSIGVDDMFIAVAAWHNTEMKYPgrs 404  Caenorhabditis el...
Q18129    311 hrtgqVMPDWVRSKPLVAAAGLMTPIMATVTSFGLILWCGFLYNAIVNVSPFLILCIGIDDLFIMCAEWHRTNPQHS--- 387  Caenorhabditis el...
Q19945    290 ss--aTKIDWISSKPWLAAAGMFSTVLSIISAFGFLFILGVRYNVINTIIPFLIIAIGIDDMFLMNACWDQTSKSLS--- 364  Caenorhabditis el...
O61894    287 ----------VTSKPIEAMIGILVSSMAIVSAGGLLFALGVPFINQVTVMPFIALAIGVDDVYVMLGAWQDTRRTLD--- 353  Caenorhabditis el...
O44978    265 ----------VKMAFYLVATSLLTPMAATVASFGAICWMGFPSFSIQCVTPFLVLgIGVDDAFILLHRWKHHIAITD--- 331  Caenorhabditis el...
Q21883    283 -----RLDQWSVHKVSEAILACVCPLLATSSALGTLFWFGFRFGTILCVTPFLILAIGVDDAYLQVHACMRLTAEDSsm- 356  Caenorhabditis el...
P91129    289 g---sFSIDWVLSKPILSILGVVSAGIAILTGVGFLSLMGMPYNDIVGVMPFLVLAVGVDNMFLMVAAVRRTSRTHT--- 362  Caenorhabditis el...
NP_493718 312 -----YTKQLNFYKPILAVMACVCPFMACGASLGAMFFIGFRFGSILCVTPFLVLAIGVDDSYLMANAWQRITCHRRkha 386  Caenorhabditis el...
Q09938    405 -----pkvMKKRMIEAMSESAVAIFITSFTDVLSFGAGTITDIIAVQGFCAMTAACMFFTFLYQITFFAALMVISAKAQM 479  Caenorhabditis el...
Q18129    388 --------PEKRIGKTLSEAAVAISITSLTDIATFAMGCYTTLPGVQMFCMYTCVQCFFCYVYQIIFLGPVLAYAAEMEQ 459  Caenorhabditis el...
Q19945    365 --------VPERMSKTLSHAGVAVTITNVTDVMSFAIGCITDLPGIQFFCIYACVSVAFSYFYQLTFFSGAMAIMGEVER 436  Caenorhabditis el...
O61894    354 --------AKKRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREA 425  Caenorhabditis el...
O44978    332 --------TPRRLEQVIVDVGPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIVFLCNDPDY 403  Caenorhabditis el...
Q21883    357 -------tKREKIARMLVEVGPSIAITSMTNLFAFLVGIYTPTPEISLFCAGNAVAILFDFIYQITMYTAILSICENLEM 429  Caenorhabditis el...
P91129    363 --------VHERMGECLADAAVSILITSSTDVLSFGVGAITTIPAVQIFCVYTGVAIFFAFIYQITFFAACLALAMKHEA 434  Caenorhabditis el...
NP_493718 387 rfesvnveLKNRITEMFIETGPSITITTITNALAFGIGATTPAAEIQLFSIGNALAVITDFVFTITFYGALMAVVGRYEI 466  Caenorhabditis el...
Q09938    480 SGRNSCMPC-------IT-------Ag----------DIYTIEDGSLQPnlkkkksksrkdakaekekkdeakndknmei 535  Caenorhabditis el...
Q18129    460 NGQHVLLIRka---vdPDkte--spVklwllsgsvnrQDQEARRRNSRKvapvekegekkskfg---------------- 518  Caenorhabditis el...
Q19945    437 EKRHCLFFYrtfqlvdISkmneeadS-----------KLQQIKSRSASPapfnylsssnssfssdsdsfss----kktip 501  Caenorhabditis el...
O61894    426 AGYHCVFVW------------------------------KRCDREEIAK------------------------------- 444  Caenorhabditis el...
O44978    404 KS---------------------------------------IANET-EP------------------------------- 412  Caenorhabditis el...
Q21883    430 RKN-------------ATk---------------------RKDSGLSFK------------------------------- 444  Caenorhabditis el...
P91129    435 SGRNSLFLIea---vsAEkkt--slS-----------TFQRLFNLGSVPd------------------------------ 468  Caenorhabditis el...
NP_493718 467 EQELKTQKP-------LPese----------------spSETSSTGSMR------------------------------- 492  Caenorhabditis el...
Q09938    536 eenaenaekssydsspDPSQIHIP--VKSrgamgHFFRDYYVPWLLNWKTKLFMFVTFIIYLGISVYGICVMEQGLDYDK 613  Caenorhabditis el...
Q18129    519 -evveklehtlekhddDPGHNSEEt-LVS-----KVFREIIGPFILQKSTQVCALLLYLVYISLAIGGCLNIKEGLDPKL 591  Caenorhabditis el...
Q19945    502 aefawkeqqspnsslsKKSKDREEkdRIV-----HFIGKIYGPFILSNSVRIFSGLIFVVYLAIAMYGCYNFREGLNPGN 576  Caenorhabditis el...
O61894    445 ----------------AKNENAIS--PTR-----YFFENIFAPFICRPSVRFCMLNLYVVYIAIAFYGCSQLTPNLTPSQ 501  Caenorhabditis el...
O44978    413 --------------------KISR----A-----DTWLSKYSSFVCSVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAK 463  Caenorhabditis el...
Q21883    445 ---------------------NEQ----F-----TVMLDSYCDWVANAYTHLLVLFCFIVYIFVSIRGALNINIILSPDK 494  Caenorhabditis el...
P91129    469 ---------------hSASHDVKQp-LTS-----RFFGEWYAPVLMHPVVRGIAMVWFVIYLLGASYGCSRIKEGLEPVN 527  Caenorhabditis el...
NP_493718 493 ------------------SSELDD--CKF-----RRMIANVCKFLTNTWVCSVVLGLLAVYWYICIVGTVNIKSELSPNK 547  Caenorhabditis el...
Q09938    614 LLLHSDPLVEALK-REIELFHGGDQIEIAIQNCPNITI-AESRDRIELVAQEFENISYSLGGKGTSFWMREYKK-Ysn-- 688  Caenorhabditis el...
Q18129    592 LVRESFYLSKFYEiIDETFWREGLQMQVVVNNPPDLFT-PETRKGFDEMMAEFENTQYTMHPNATMIWLRAYEHhLe--- 667  Caenorhabditis el...
Q19945    577 LVTNDHYIAKYFSdI-KHFWRIGAQLHVAVLNPPNLTI-SENRNELLKVVSAFENTQYTLGREGTVFFLLEYLNyLse-- 652  Caenorhabditis el...
O61894    502 LVVDDSPLVPYLNlAEKKIWAEGLIGRIYVNNAPDFSKnPEMVDRMLQMVNELESTPYSMGPNSTNFWLNEFN--Ny--- 576  Caenorhabditis el...
O44978    464 AFPSNSKLVDSLSnI-KPVFNRYFPITVIVNNPPNIEI-KAEYDSFNNMMDRLEHVPGIRGDNRSLIFLPQYVNfDkt-- 539  Caenorhabditis el...
Q21883    495 LVIGDSPLLQVNYlRDQFVLPNYTTVNIFVQNPGNLTI-QSNLDYMNSLFDSFESYPECLGKKFSHYFVRDYESfRess- 572  Caenorhabditis el...
P91129    528 LLVEDSYAIPHYRlLEKYFWKYGQQVQIVINNAPDLRN-HTSRDRVHAMVLDFATSKHAIGMESVQFWLFEMER-Yy--- 602  Caenorhabditis el...
NP_493718 548 LFLAESNIVEIFKqRKSHIIPYYSACWVLVENPGDINN-PNQRAKLEELIESFEALPSANGRYSTKFWLRDYEDfLkqse 626  Caenorhabditis el...
Q09938    689 ---lTGSYLNDNRE----------------SW-IVGVYEWSQLFAFYKL-WSQDFVWAne--sdYDTLELKSYRFRIG-- 743  Caenorhabditis el...
Q18129    668 ---tEVHELNIEKPns------------tvEW-YTRCRDWLIVAGGRRL-WQMDMVWAnt--tfEETPRITAFRFQLG-- 726  Caenorhabditis el...
Q19945    653 ---lNAEVEDTER-----------------LW--KTKLNSWLKYTGGSTqWASNLKIN------KTDGSFQAFRFQIA-- 702  Caenorhabditis el...
O61894    577 ---rQFFFQEDAK--------------------FYETLKSFLKVSFNSH-WETDLVWDtpdkssKGGTKVEKFVFTTA-- 630  Caenorhabditis el...
O44978    540 ---mNILSTLVGEK----------------YRpSYDNLPTWMDAIGNPP-LVKYHMGD------DNKTIVTAFRLTLL-- 591  Caenorhabditis el...
Q21883    573 --leEMEMMEDEEGdtnk---------talEPfSKAAMSEFLAWPEFQH-WNGFVKFD-------KNGMLSKYWATVSyh 633  Caenorhabditis el...
P91129    603 ---qKELEVQIID-----------------SS-FYGLLHHFLASKTNNP-LAEDIYWGpmp-ddDNGTMVKSFRFILG-- 657  Caenorhabditis el...
NP_493718 627 eidlPMEEEEDEELaiqftvngsqvvtpsqPFgQGNELRQFLEWPEFSF-WKGFIQVN------ESTYQMSKFLVTTAyh 699  Caenorhabditis el...
Q09938    744 VHRLSTPTDLVLITEELRGVADRHPD--LNIVTYQQSRAIADQLNVILSSTITNDTLAMFCMFCVALIFIPNPICALFIT 821  Caenorhabditis el...
Q18129    727 LRNYRTPTDHTHSCKLMRSIADKYSM--FNVTTFHEYYPFADQYLELTPSLFQNMISDLCTIFAVSWVMIPELICAVAIV 804  Caenorhabditis el...
Q19945    703 LKNFVEPNDHKHAAQLLRDIAD-HQP--FNVVVYHEAFPFADQYLIILPATIQNVVISLLCMAVVSFLLVPSLPSGFVIF 779  Caenorhabditis el...
O61894    631 -FKISNWNIRTSLLLTWRNITSSYPE--FDALVFDENNFYSDQMLELQSTILSSLGTAIILLSAICIMFIAESYIVFWVV 707  Caenorhabditis el...
O44978    592 GKGMSEWAERARAMQHIRTILHEESQ--FNATLFDCDSAILSIILTVGTDLIGSIAVTVVCMAIVCFVFIANFNAVAVIT 669  Caenorhabditis el...
Q21883    634 GEGLGDFQVRRRMLNRWRATADQFAP--LNVSIFDDYAPFVDTLETILPATISTSVCTLICMMIVCFLFMYNVFTVFVAT 711  Caenorhabditis el...
P91129    658 MKDLVTTMDQTDATMSFREVAARWPE--FNVTTFMPIWMFTDQYIIIIPNTVQNIIIALLVMIVIAVLFIPQPMCSLWVA 735  Caenorhabditis el...
NP_493718 700 GSDLVDWSNRAKLLNEWRSVADQDKFksLNVTVYEEDAKFLDLIETMSPVAIQSALWTFASMFLVAALFISHPPTLFVAT 779  Caenorhabditis el...
Q09938    822 FAMVTIDIGVIGFLSLWSVKLDPISMITIIMSIGFSIEFSAHITHGFVSNDSn---lSAFDRCVDAMEKLAWPVVHGSLS 898  Caenorhabditis el...
Q18129    805 LSIASINVGVLGFMSFWGVNLDSVSIITVIMCIGFSVDLSAHIAYAFSQSYG-----NSHARAVAALETLGWPVFLGASS 879  Caenorhabditis el...
Q19945    780 VSIVSINIGVFGYMTLWGVNLDAVSMISIIMSIGFAVDLSAHIIYAFVTSHG-----DTKQRVIGALETLGWPIFQGASS 854  Caenorhabditis el...
O61894    708 CTLISMDIGTAGLLSLWGADLDPMTVVNILMSIGQCIDFATHVGIRIYRSEYs----DPDERIRDAMGAIGWPVVQAGTS 783  Caenorhabditis el...
O44978    670 SVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRARG-----TPQERVYSSLAEMAMPMCEAGLS 744  Caenorhabditis el...
Q21883    712 LAITSICIGVFGFLSMWGIDLDPISMACLIMSIGFSVDFPAHITFHYFREGLhdpqsTPAKRVARSLAAIGFPLLQCGLS 791  Caenorhabditis el...
P91129    736 LACASIDFGVIGYMTLWGVNLDAISMITIIMSIGFSVDYSAHIAYGYVVSREd----TAAGRVKEALSALGWPLSQGAMS 811  Caenorhabditis el...
NP_493718 780 FSILSTSLGVFGIMSWWGADLDPIMMSATVMSIGFSVDIPSHVSYHFYQTAKdt--sDIRRRLQMTIEAVGFPIFEASLS 857  Caenorhabditis el...
Q09938    899 TILGVFVLAFIDSYMVLVFFKTISLVLIIGAWHALMLLPILLSMCIP 945  Caenorhabditis elegans
Q18129    880 TVLGILLLTLVDSYIVQIFFKTVFLVINFSILHGLIFLPIFLMKVVR 926  Caenorhabditis elegans
Q19945    855 TIAGISILYTVDAYIILVFFKTIWLTMLIGAIHGLFFIPIFLSLFPV 901  Caenorhabditis elegans
O61894    784 TLLAIVVMLMVPSSAVRMFARTSVLVVGTGFFHGLIILPIIVRSFAT 830  Caenorhabditis elegans
O44978    745 TFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFILPVILALFSK 791  Caenorhabditis elegans
Q21883    792 TILFVLCLLFVPTYMGEVFVKTMILVVTLGLIHGLFIVPAFLCAFTA 838  Caenorhabditis elegans
P91129    812 TIIAVSVLADIPAYMIVTFFKTVVLSISLGLLHGLVFLPVLLSIFVR 858  Caenorhabditis elegans
NP_493718 858 TSLCVMSLFFVDLNMAQIFAKCMLLVVVIGMVHGMLVMPVIFALLDT 904  Caenorhabditis elegans
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap