Conserved Protein Domain Family
HSR
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pfam03172: HSR (this model, PSSM-Id:308673 is obsolete and has been replaced by 460835)
HSR domain
The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.
Links
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Statistics
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PSSM-Id: 308673
Aligned: 62 rows
Threshold Bit Score: 104.52
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3KRF1         8 LEKALLQHFIYTKLDIAYAINKPFPFFEALRDNSFITERMYKESLEACqNLVPLSKVVHN-----------ILTSLEQTF 76  Norway rat
XP_015216561   8 EDADLRSQLRMLRTEIAMAIDDPFPLLYGLADHDIITEQLFKDTLDKKk-HEGIHKAVYS-----------LLSRLLEKE 75  spotted gar
CAG07656       5 gETNLRSLLKHLRTDIAMAVDDSFPLVYGLADKNIITDQLQKDTLE-KeSREGIHKAMYS-----------LLSWVLQQR 72  spotted green p...
XP_007667882   5 LEKQLLIKFREKKLAISDAVNKLFPFIYSLRDQALISNRMLQHYKN---ESVPMKERIYN-----------VLEKLEKNF 70  platypus
XP_009296781   8 EESDLRSQLRACRTEIAMAIHDPFPLLYGLADHNVISEQILRETLERKk-KDGIHKAIYSlltllldqdttVL------- 79  zebrafish
XP_011476751   8 ESAQLQQFFHSRKTELS-CLENPQTFLSQLRDYNLIPEDRYKKVIKMk-SKDRRRMAIYE-----------FLDWMERER 74  Japanese medaka
XP_010714879  34 LDRDLRHLLKLHRTEIAMAVDDVFPLLHGLADHDIVPEHIFKETLSQT-EREGSHRAFHA-----------LLTWLLGRD 101 turkey
NP_001258486   4 GDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLK-EKEGCPQAFHA-----------LLSWLLTRD 71  house mouse
XP_013124273  25 RDTNLRSLLRELRTDIAMAVDDPFPLVYGLADKNIITEQLLKETLEKE-AREGIHKAMYS-----------LLSWVLEQS 92  Nile tilapia
XP_011614747   5 rDTNLRSLLRQLRTDIAMAVDDSFPLVFGLADKNIITDQLQKDTLEKE-SREGIHKAMYS-----------LLSWVLEQR 72  torafugu

Q3KRF1        77 DPSM---LLILFSKVNLREYPSLGAICRSFRNV 106 Norway rat
XP_015216561  76 TLTIqnfWSNLFKDYNLERYPKLQSVFTSFPKD 108 spotted gar
CAG07656      73 RSVIrafWSNLFKDYNLDSYPKLQKLITNLPSG 105 spotted green pufferfish
XP_007667882  71 NKKV---LKVLFSRNNVKEYPDLKRIRRTFEDV 100 platypus
XP_009296781  80 -KAF---WKNLCKEYNKECYPKLETVFMNLPKG 108 zebrafish
XP_011476751  75 SEHIplfWRCVFKEIILSQYPIFRLMRNSLMDG 107 Japanese medaka
XP_010714879 102 AAAVrdfWAVLFKDYNLERYTRLRPLHSTFPAE 134 turkey
NP_001258486  72 SGAIldfWRILFKDYNLERYSRLHSILDGFPKD 104 house mouse
XP_013124273  93 RSTVqafLNNLSKDYNLDSYPRLQTLLTNLDCR 125 Nile tilapia
XP_011614747  73 RSIIrafWSNLSKDYNLDSYPKLHKLIANLPcr 105 torafugu
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