Conserved Protein Domain Family
TPD52
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pfam04201: TPD52 (this model, PSSM-Id:309362 is obsolete and has been replaced by 461225)
tumor protein D52 family
The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.
Links
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Statistics
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PSSM-Id: 309362
Aligned: 22 rows
Threshold Bit Score: 163.769
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3SYU8        20 DSMTDVPVDTAVAAQAPAv-eGLTETEAEELRAELAKVEEEIVTLRQVLAAKERHCGELKRKLGLSTLEGLKQNLSRSWH 98  cattle
XP_007255466  37 EPLQEVDEEMVSEVDLNN---TITEEEKEEMHNELTKLEEEIATLRQVLSSKEKRHSELKQRLGITPLSELRHNLSRGWN 113 Mexican tetra
XP_011490162  91 EPLREADEDAASEVHLNNs--TMTEEEREEIQQELVKLEEEIGTLKQVLSSKEKQQAELRQKLGITPLSELKNNFSRSWH 168 Japanese medaka
XP_007484569  18 DPLHEPVEETISHIDLNS----ISEEEREELKTELVKLEDEISTLPQVLTAKEKHLVEIKQKLGMNLMNEIKQNFSKGWH 93  gray short-tail...
XP_015215213  12 EPLQEVDEDVVAEVDLNNs--V-SEEEREEIQTELAKLEEEIAALKQVLAAKEKHHAELKLKLGMNPLNDLKQNVSKSWH 88  spotted gar
XP_007656188  62 EPLQGANEGRSSEIVFLS---MISEEEREELKTELVKLEEEVSTLRQVLSAKEKHRLEIKQKLGMTLMDELRQNLSKGWH 138 platypus
OCA33834      13 QPLQETDEELATDIDYSE---TISEEEKEELKSELFKLENEIVTLRQVLAAKEKHLVEIKQKLGVSMMNELKQNFSRSWH 89  western clawed ...
XP_011610284  45 GPLKETDEDSGSEVNLNSs--IMTEEEREEILQELAKLEEEIGTLRQVLSSKEKQHADLRQKLGINPLNEIRSNFNRGWR 122 torafugu
XP_007249368  47 DSIPEVGEDAVTTVGETTpstALTEEEQEELRNELIKVEEEIQTLSQVLASKEKQVAEIKRKLGITPLNELRQNLSKSWQ 126 Mexican tetra
XP_012351539   7 DPVPEEGEDVAATISATE---TLSEEEQEELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQ 83  northern white-...

Q3SYU8        99 DMQVSNAYkktqetlsqagQKTSAALSTMGSAISRKLGD--------------MRNSATFKSFEDRVG----Ti----kS 156 cattle
XP_007255466 114 DMQTSTAYkktsetlstagQKTTAAFSNLGSAISRKFGD--------------MRNSPSFKSFEEKVEntvtNi----kS 175 Mexican tetra
XP_011490162 169 DVQTSVAFkktsetfstagQKTSAAFSTFGSAITRKLGD--------------MRNSPSFKSFEEKVEstvsTi----kT 230 Japanese medaka
XP_007484569  94 EMQTTTAYkkthetlshagQKATAAFTNVGTAISKKFGD--------------MRNSPTFRSFEERVEttvtNl----kT 155 gray short-tail...
XP_015215213  89 EVQTSTAYkktqetlstagQKATAALSNVGTAISRKFGD--------------MRNSPSFRSFEEKVEstvsTl----kT 150 spotted gar
XP_007656188 139 DVQTTSAYkkthetlsqagLKATAALNNMGMAISRTFGD--------------MRNSSTFKSFEERVE----TtvtslkT 200 platypus
OCA33834      90 DVQTHSAYkktqetlsqagLKATAAITNVGSAIGKKLGD--------------MRNSPTFKSFEERVE----NtvttlrA 151 western clawed ...
XP_011610284 123 DVQTSVAYkktsetlstagQKTSAAFSTLSSTISRKFED--------------MRNSPSFRSLEEKMEntvsNi----kT 184 torafugu
XP_007249368 127 EVTTSTAYrrtsetlsqagQKATATFTSVGSAISRKLEDvsirsiqhstsmpvMRNTPTFKSFEDRVE----Si----kT 198 Mexican tetra
XP_012351539  84 DMTATSAYkktsetlsqagQKASAAFSSVGSVITKKLED--------------VKNSPTFKSFEEKVE----Nl----kS 141 northern white-...

Q3SYU8       157 KV--VGGREn---gGDNLPSPTGSGD 177 cattle
XP_007255466 176 KV--GGTSSgg-sfEEVLSSAAQASA 198 Mexican tetra
XP_011490162 231 KV--GGSGPgg-nfEEVLSSAANASS 253 Japanese medaka
XP_007484569 156 KV--GGIPMgg-nfEEVLsstahasa 178 gray short-tailed opossum
XP_015215213 151 KVg-GSSSSrg-sfEEVLSSTAHASA 174 spotted gar
XP_007656188 201 KVggAGGSSgg-sfEEVLsstaqass 225 platypus
OCA33834     152 KV--GSANQtqgsfEEVLSSTAHASA 175 western clawed frog
XP_011610284 185 KV--GASESkg-nfEEVLssaasass 207 torafugu
XP_007249368 199 KM--SPTPSts-elGDVSNSIPNAES 221 Mexican tetra
XP_012351539 142 KV--GGTKPaggdfGEVLNSAANASA 165 northern white-cheeked gibbon
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