Conserved Protein Domain Family
HNF-1_N
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pfam04814: HNF-1_N (this model, PSSM-Id:309793 is obsolete and has been replaced by 461440)
Hepatocyte nuclear factor 1 (HNF-1), N terminus
This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerisation sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Links
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Statistics
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PSSM-Id: 309793
Aligned: 17 rows
Threshold Bit Score: 184.74
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q1L9E9        38 EQIDLLQRLRLSGMTKPQIIQALESLDRLD---PDH-------RTPC---------CNNHSTQP--SAPTSAAPAAPSss 96  zebrafish
NP_919353     12 LQQELLSALLDSGVTKDVLVQALEDLCPCP---AEFgik-iekPLSPssa----ngGSDCGDSKp-VFLTLTGAQGKG-- 80  zebrafish
XP_007259666   8 LQQELLSALLDSGLTKDALLRALEDLPPCP---QGLgik-terPLSP---------VSDC-DSKp-VLLTLGRG------ 66  Mexican tetra
XP_001089567   8 LQTELLAALLESGLSKEALIQALGEPEPYlla--------gdgPLDK---------GESCGGGRg-ELAELPNGLG---- 65  Rhesus monkey
KFP69178       8 LQVELLGALLESGLTKETLIKALSEVEPY----VLQsesqraiNALQ---------TEK-GEPCp-NIPNLPNGMGE--- 69  red-legged seriema
CBY14302      59 EQIWLLQRLRGSGLNREQIVAGLEDLDRLDvtgRPHsansdlaKSAEnsdsektsaGNAANQIGgaGIPNFNQSQSVLqk 138 Oikopleura dioica
XP_012810750   8 LQRELLRALLESGVTKEALKKALADGDDYT---YPNvplddirNLDE---------GENCVQ--------LPNGLGDPqi 67  western clawed ...
XP_799101      9 EQIELLRRLVRTGLTKDEIIHACDSMAKMD---SELgplpskiEQP--------------------IFTSVNSAASPPis 65  purple sea urchin
ELW61746      42 kletlplspgsgaepdtkpvfhtltnghakgrlsgdegsedgddydtppilkelqalnteeaaeqraevdrmlrpsagrp 121 Chinese tree shrew
XP_016158561   8 LQRELLGALLSSGATKEGLIRALEDMVPA----AGFgvkleslPLSP---------GGAP-DGRa-ALPALANGHGk--- 69  collared flycat...

Q1L9E9        97 sss------sssltSATTQTpv--idAALSP---------SNSYDASPPPlyppsgvqrsfsydlaEE--DWDLEE---- 153 zebrafish
NP_919353     81 --------------GKLSGD------EGSED---------GDDFDTPPIL----------------RElqSLNTEEaae- 114 zebrafish
XP_007259666  67 --------------SKMSGD------EASED---------GEDRDTPPIL----------------RElqALNTEEaeq- 100 Mexican tetra
XP_001089567  66 ------------------ETrg--seDDTDD---------DGEDFTPPIL----------------KEleNLSPEEaah- 99  Rhesus monkey
KFP69178      70 --------------SRLSED------ETSDD---------GEEF-TPPIM----------------KEleNLSPEEaah- 102 red-legged seriema
CBY14302     139 nlsqaa-aailstqSKLPQTpfpniwSNQRPthlnhyaalGNNFSSGISTngedqkp--dvfarknEEpdDLA-DEieq- 213 Oikopleura dioica
XP_012810750  68 s-----------------------edESSDD---------GGDF-TPPIM----------------KEleRLSPEEaah- 97  western clawed ...
XP_799101     66 syhapqqltvtnrnSGLDTTggl-gqEPASP---------GNRTSLVTLLsnaghgg---fqengdGGdgGRGGVDdfhv 132 purple sea urchin
ELW61746     122 wsrrlillaqasardlrafptgsglglgdpelrgrvpcreaatrtegaqrlldfmwvpshcavgrspgvasdtagpsfqg 201 Chinese tree shrew
XP_016158561  70 --------------GKLSGd------EGSED---------GDDFDTPQIL----------------RElqSLNTEEave- 103 collared flycat...

Q1L9E9       154 ---KVEEYMRRDSNLVKEEIKAFLNNRRISQAIVGQVT--GISQSYISQWLLqQGLEMSDSKRRAFYRWYL 219 zebrafish
NP_919353    115 qraEVDRMLSEDPWRVARTIKGYMQQHNIPQREVVDVT--GLNQSHLSQHLN-KGTPMKTAKRAALYTWYV 182 zebrafish
XP_007259666 101 qraQVERMLAEDPWRAARTIKSYMQQHNIPQREVVDVT--GLNQSHLSQHLN-KGTPMKTTKRAALYTWYa 168 Mexican tetra
XP_001089567 100 qkaVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTT--GLNQSHLSQHLN-KGTPMKTQKRAALYTWYV 167 Rhesus monkey
KFP69178     103 qkaVVERLLQEDPWRVAKMVKSYLQQHNIPQREVVDTT--GLNQSHLSQHLN-KGTPMKTQKRAALYTWYV 170 red-legged seriema
CBY14302     214 ihrAVEYCERRNQHEVKEEIRIFTQRHHISQTAISKAThqAISQSYISQWLT-SNITMGDAKRRIIYEWFV 283 Oikopleura dioica
XP_012810750  98 qkaVVERLLQEDPWHVAKLIKSYLQQHNIPQREVVDTT--GLNQSHLSQHLN-KGTPMKTQKRAALYTWYV 165 western clawed frog
XP_799101    133 tneEVESLFRKGHMNVKEDIKDFLTRNRLSQNLISQST--GISQSYISQFLL-HGYVMRRSTQAILYRWFL 200 purple sea urchin
ELW61746     202 rggrtevaPSEDPWRAAKMIKGYMQQHNIPQREVVDVT--GLNQSHLSQHLN-KGTPMKTQKRAALYTWYV 269 Chinese tree shrew
XP_016158561 104 qraEVERMISEDPWRAAKMIKGYMQQHNIPQREVVDVT--GLNQSHLSQHLN-KGTPMKTQKRAALYTWYV 171 collared flycatcher
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