Conserved Protein Domain Family
SNF5
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pfam04855: SNF5 (this model, PSSM-Id:309818 is obsolete and has been replaced by 428158)
SNF5 / SMARCB1 / INI1
SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumors (MRTs).
Links
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Statistics
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PSSM-Id: 309818
Aligned: 102 rows
Threshold Bit Score: 137.598
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q09699       136 KLPVDLVPIRLEIDADR-------YKLRDSFTWNLYDKCISLDQFAEQICIDYDIPlhnVHIVQNISKSIQAQINDYepr 208 Schizosaccharom...
XP_007845513 280 RRPSALVPIRVEFDTDT-------HRIRDCFVWNLYEEAIKPEAFARIFCNDLDLPvd--tWADTVANQIKAQLEDCenv 350 Moniliophthora ...
EPT02261     248 RKPTALVPIRVEFETDT-------HRIRDCFVWNVHEDLIKPESFARTFCADLDLPan--pWADLVAAQIRAQLEEHegi 318 Fomitopsis pini...
EMD39783     283 KKSTALVPIRVEFETDT-------HRIRDCFVWNLHENLIKPEAFARTFCADLDLPvn--pWAELVANQIRAQLEEHegv 353 Ceriporiopsis s...
XP_007399485 278 RKPVALIPIRVEFETDA-------HRIRDCFVWNLHEDLIPPEVFARTFVQDLDLPeh--pWVELVANQIRAQLEEHegv 348 Phanerochaete c...
XP_002474491 172 RRPTSLVPIRVEFETDT-------LRIRDCFVWNLHEDLIKPESFARAFCVDLDLPvn--pWAETVANQIRAQLEEHegv 242 Postia placenta...
EGN98539     237 RKPTALVPIRVEFETDT-------HRIRDCFVWNMNETLIKPEAFARTFCSDLDLPai--pWVDTVTNQIRAQLEEHegv 307 Serpula lacryma...
CCA69450     192 SLPVVLIPIRIELDTDR-------YRIRDCFMWNLN------GIFAQIFCYDLGLE---AYYMEQVSNQISAQLEEHgat 255 Piriformospora ...
EKD00182     245 GRAEALVPISIDYDIPDpngegkgLKIKDRFLWNASEPFVKPLEFATIFCHDVGIHe---nNAATIAELIMSQVEEQqna 321 Trichosporon as...
XP_003331597 298 SDSVCLVPIRIELDTDE-------LRIRDVFTWNLRERYITPEIFSLEFCADAGIQsg--vYVPKIVEQIKSQLNQYsfl 368 Puccinia gramin...

Q09699       209 kaqsnlsfvsdvssstsetvyahepsdslakaskqqiptvqNDLRILIKLDITIGRLNLIDQFEWNLFAPEsSAEEFATV 288 Schizosaccharom...
XP_007845513 351 vrmelgmdga-------------------vdferqgtvdeiPECRVILSIDVQIATHHLLDHIEWDLLSPL-TPEAFATT 410 Moniliophthora ...
EPT02261     319 aaldlgtea--------------------diedetseggevPECRVILSIDVQIANHHLSDHIEWDLLSPL-TPEQFAGT 377 Fomitopsis pini...
EMD39783     354 asldlgadyhm----------------dvdgdsdntsveeiPECRVILSIDVQIAGYHLVDHIEWDLLSPL-TPEAFATT 416 Ceriporiopsis s...
XP_007399485 349 gsmdfdva-----------------------npfgpgedevPECRVILSIDVQIATYHLLDHIEWDLLSPL-TPEQFASQ 404 Phanerochaete c...
XP_002474491 243 aavdfgvpdp-------------------emeeklrageemGECRVILSIDVQIATYHLCDTIEWDLLSSL-TPEAFASK 302 Postia placenta...
EGN98539     308 asmdlrgam--------------------didmddengeeiPECRVVLSIDVQIATHHLLDHIEWDLLSAL-TPEAFSQQ 366 Serpula lacryma...
CCA69450     256 aaldlpvnte------------------regeilheddagpGDCRVVLQIDVQIGTKHMLDHIEWDLRSPL-TPEEYTSV 316 Piriformospora ...
EKD00182     322 vaidlatrdvtpdd-----------vvfsddespaddeypePDCRIIVNLDLQIFQHVLRDRIEWDLSSPL-PPAEFARH 389 Trichosporon as...
XP_003331597 369 satklvpdead-----------------lshftddqlvgiePDLRVVIQLDVQIETLHLVDRIEWDLASPL-TPELFTAQ 430 Puccinia gramin...

Q09699       289 MCLDLGLSGEFCTAVAHSIREQCQMYIKYLSligylfdgseiedeevrsy------------------------------ 338 Schizosaccharom...
XP_007845513 411 LCADLGLSGEAIPLVAHAIHEELIKHKKDVVdwgiissaaaatesgltkdktgl-------------------------- 464 Moniliophthora ...
EPT02261     378 LCAELGLAGEAVPLIAHAVHEELLKHKRDAWewgvlgieqqhaadedrprdrsgasllkdktg---------------lg 442 Fomitopsis pini...
EMD39783     417 LCAELGLAGEAVPLIAHAVHEELVKHKRDAVewgvigvetreadepaadrprdksglsllkdkt-------------glg 483 Ceriporiopsis s...
XP_007399485 405 LCADLGLAGEAVPLVAHAIHEELIKHKRDAIewgivgvdphpsahddpdrprdrsglsllkdkt-------------glg 471 Phanerochaete c...
XP_002474491 303 LCSELGLSGEAVPLVAHAMHEEIVKHKRDALewgviggdareadderprdksglsllkdktg----------------lg 366 Postia placenta...
EGN98539     367 LCSELGLTGEAIPLIAHAIHEELVKHKRDAIewgviggdkdpaeepapdkprdksglsllkdkt-------------glg 433 Serpula lacryma...
CCA69450     317 FCADVGLSSEAVPMIAHAIHEELLKHKKDVIewgvlegggewkshaaglgnawgr------------------------- 371 Piriformospora ...
EKD00182     390 YCAELGLTGEAVPIVAHAIHEELIKHKRDALemdlfaqthpgeqakwertggqpk------------------------- 444 Trichosporon as...
XP_003331597 431 YICDLNLPRSASPIIAHAIHEEICRHKRDCLslglisqevlsssvavpndadpqttttasttptpnpvgivqtsfkiesd 510 Puccinia gramin...

Q09699       339 ----------ilpplkntlrfsdmesssfAPMIYELNDAEMERQ 372 Schizosaccharomyces pombe 972h-
XP_007845513 465 -------grvrgpkplksvwrdwaeaeefRTRFEEMSQEEVERR 501 Moniliophthora roreri MCA 2997
EPT02261     443 lawgrapkdgrgpkalrsvwrdwqeaeefRTRFEVLTAEEVERR 486 Fomitopsis pinicola FP-58527 SS1
EMD39783     484 lgwgrapkdgrgpkslksvwrdwaeaeefRTRFEVLTQEEVERR 527 Ceriporiopsis subvermispora B
XP_007399485 472 lgwgrtpkdgrgpkslrsvwrdwaeteefKTRFEVLTPEEVERR 515 Phanerochaete carnosa HHB-10118-sp
XP_002474491 367 lgwgrapkdgrgpkplrsvwrdwaeaeefTTRFEVLTAEEVERR 410 Postia placenta Mad-698-R
EGN98539     434 lgwgrtpkegrgpkllksiwrdwpeaeefRTKFEILSAEEVERR 477 Serpula lacrymans var. lacrymans S7.3
CCA69450     372 ------kgkgpkrmkgiwrdwaeivsgdySPRIEELTAEELEKK 409 Piriformospora indica DSM 11827
EKD00182     445 ------tnsrtgakglvgvwrdwwerdefSPLLFEISHDDMVKR 482 Trichosporon asahii var. asahii CBS 8904
XP_003331597 511 pllkekygssrgpkklegvwrdwheanlfGPKLQLIHVEDLEWA 554 Puccinia graminis f. sp. tritici CRL 75-36-700-3
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