Conserved Protein Domain Family
Sperm_Ag_HE2
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pfam05324: Sperm_Ag_HE2 (this model, PSSM-Id:310140 is obsolete and has been replaced by 461622)
Sperm antigen HE2
This family consists of several variants of the human and chimpanzee sperm antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a family of androgen-dependent, epididymis-specific secretory proteins.The EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages. The translated putative protein variants differ significantly from each other. Some of these putative proteins have similarity to beta-defensins, a family of antimicrobial peptides.
Links
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Statistics
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PSSM-Id: 310140
Aligned: 13 rows
Threshold Bit Score: 84.5148
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q30KR3         8 LV-SFLLVALMFP-GPSRARNINHQGTEG---PREPWEESPGQGKNESHLLHHREKRrlL-PRTPPYLE 70  dog
Q3UW43         8 FFaSLLFAALLFPaGLSNASSINHLVTEP---PSFPKDEFPARGVNGSQLLHHRVKR--LpPRTPPYHG 71  house mouse
Q8SQD1         8 FFtSLLLVALLFP-GLSQARHVNHSATEA---LRELREGATGQGTNRSQLLRHPVKRapIiRRIPYYPE 72  Rhesus monkey
XP_008977269   8 SFaSLLLVALLFP-GSSQARYVNRSAMAA---PRELGEGAPGQGTNGSQLSHHPVKRdlLpPRThltkv 72  white-tufted-ear marmoset
XP_009241799   8 SVaSLLLVALLLP-GSSQARHVNHSATDA---LGELRERAPGQGTNRFQLLRHPVKRdlLpPRTPPYQe 72  Sumatran orangutan
NP_478110      8 sVtSLLLVALLFP-GSSQARHVNHSATEA---LGELRERAPGQGTNGFQLLRHAVKRdlLpPRTPPYQE 72  human
NP_001291353   8 SFvSLLLAALLLP-GSSSASSINHLVTEP---PSSPQDEFPAQGGNGSGLLHHRVKR--FpPRTPPYHE 70  Norway rat
XP_002929982   7 LFiSLLLVALMPP-GQSRAGNVNHQGTEGlrePRESREESPGQGKNGSPLFHHQEKRqlL-PRTPPYPE 73  giant panda
XP_003984612   7 VFpSFLLVALLFP-GLSGARNEDLQGTEG---PRERREESPGQGTKGSHLLHHQEKRhiL-PHTPPYEE 70  domestic cat
XP_003362124   7 PL-TLLLVVLLFP-GFSRATYANYQGTKG---PRELKGEYPGQETNKSHLLRHQVKRylL-PRTPPFQE 69  pig
XP_005903844   8 S--TLLFVVLLFP-GLSRVTHANRQDPKG---PRK-QEESLGRGTNRSHPLHHQVKRylV-PRKPPFPD 68  Bos mutus
XP_005606516   7 QF-ALLLMALLFP-GSARASYVNQQGTKG---PREPREESPQRGTSRAHMFRLLVEDylL-PRTPPYED 69  horse
XP_003803643   8 PFtSLLLVVLLFS-GLSGTQYVDHSSTEG---PRELGEQSPGHSS------HQQVKRyvLpPRTPPYQE 66  small-eared galago
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