Conserved Protein Domain Family
NDUF_B8
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pfam05821: NDUF_B8 (this model, PSSM-Id:310423 is obsolete and has been replaced by 428637)
NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
This family consists of several eukaryotic NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI) proteins. NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Its main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits.
Links
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Statistics
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PSSM-Id: 310423
Aligned: 6 rows
Threshold Bit Score: 244.794
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6P5L5        22 SAIIRGARAASGSS------KDSLPGPYPKTAEEKAAAAKKYNMRPEDYQPYPDDGW--GSGDYPMLPSRSQHERDPYYQ 93  zebrafish
Q5ZJW2        25 AAAPPGARAASGLT------KDQLPGPYPRTAEERAAAAKKYNMRVEDYQPYPDDGF--GYGDYPMLPNKSIHERDPWYQ 96  chicken
Q9XWJ6        16 LHLARIMSMRGPLTfdgwypRDHKPSAPPTNEEERRAAAVKYGLRPEDYQSMDKDDVikFAGDYPDLGVITYDHKDPYEA 95  Caenorhabditis ...
NP_496907     16 LHLARIMSMRGPLTfdgwypRDHKPSAPPTNEEERRAAAVKYGLRPEDYQSMDKDDVikFAGDYPDLGVITYDHKDPYEA 95  Caenorhabditis ...
NP_001138314  20 KVVPLGARTASHVT------KDMFPGPYPKTPEERAAAAKKYNMRVEDYEPYPDDGM--GYGDYPKLPDRSQQERDPWYD 91  pig
XP_005025280   2 pTLPRCCPAASGLT------SEMLPGPYPRTPEERAAAAKKYNMRVEDYQPYPDDGL--GYGDYPMLPKRSAHERDPWYQ 73  mallard

Q6P5L5        94 WDHPDLRRNWGEPMHYHFDMYIRNRVD----TSPTPLDWRTMRLWLFGFLGLTMFMFGMGEVLPS----YQPVAAKQYPY 165 zebrafish
Q5ZJW2        97 WDQPDMRRNWGEPMHWDFDMYIRNRVD----TSPTPVPWHTMRNHFLIFLGTMLVMFVLGEIYPS----YRPVGPKQYPF 168 chicken
Q9XWJ6        96 WTDRQNRRNWGELVPIDMMRYRGDRLTftglEAEDYTTWNSIVMCLRVLVPMALLAWYFTNEHPNalrwKNPAMPKQYSY 175 Caenorhabditis ...
NP_496907     96 WTDRQNRRNWGELVPIDMMRYRGDRLTftglEAEDYTTWNSIVMCLRVLVPMALLAWYFTNEHPNalrwKNPAMPKQYSY 175 Caenorhabditis ...
NP_001138314  92 WDHPDLRLNWGEPIHWDLDMYIRNRVD----TSPTPVSWNTMCKHLSGFVAFMLFMFWVGEIYPS----YQPVGPKQYPY 163 pig
XP_005025280  74 WDQPDIRHNWGEPMHWDFDMYIRNRFD----TSPTQIPWHTMRKHFLVFLSTMLIMFGIGEFYPS----YRPVGPKQYPF 145 mallard

Q6P5L5       166 NNLYLERGGDPEKEPepVKNYEI 188 zebrafish
Q5ZJW2       169 NDLYLEKGGDPNKEPpvVTHYKI 191 chicken
Q9XWJ6       176 DFYRAYPFDDPRKYP--IVNYSF 196 Caenorhabditis elegans
NP_496907    176 DFYRAYPFDDPRKYP--IVNYSF 196 Caenorhabditis elegans
NP_001138314 164 NDLYLERGGDPTKEPepVVHYEI 186 pig
XP_005025280 146 NDLYLERGGDPNKEApvVTHYEI 168 mallard
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