4Y7I


Conserved Protein Domain Family
Myotub-related

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pfam06602: Myotub-related (this model, PSSM-Id:310891 is obsolete and has been replaced by 461958)
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Myotubularin-like phosphatase domain
This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.
Statistics
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PSSM-Id: 310891
Aligned: 226 rows
Threshold Bit Score: 243.154
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4Y7I_B          8 LIDPISDFG-RM-----------GIpn-----------------rnWTIT-DANRNYEICSTYPPEIVVPKSVTLG--TV 55   human
Q7KSP6       1139 ersyvqDWK-RL-----------GFdaes--------------qrgFRIS-NANTSYATCRSYPAIIVAPVQCSDA--AI 1189 fruit fly
XP_012060555  193 LFRDISDWQnELkrtlcs----------------------detkkgWRLS-MVNAKFQLCPSLSQYVVVPASVTDS--QL 247  Atta cephalotes
XP_002110574  190 igckhtEFYtKYansmeglaktgGVpsyrkisdyeseldhlktpkiWCINeDANRGFK-YQSLPEILLCPNDAVSKklDL 268  Trichoplax ad...
XP_012812016  150 RDTMENFYH-KMrae----------------------------tddWRLS-EVNLDFKICPSYPAKVIVPRICSDE--TL 197  western clawe...
XP_007257641  145 LSSPEQDYT-QTerl----------------------------wdrWRLS-KVNSDFSVCPSYPDTLIVPSSIDDD--TL 192  Mexican tetra
XP_015204268  127 LSTPEEDFQ-QIaih----------------------------serWRLS-DVNRDFSVCPTYPPTVIVPRAVEDE--QL 174  spotted gar
CCD80361       56 leavssiddvtllypfayksnqssllpvikttdwpnninellsvgsWRIS-QLNENYSLCNSYPKTFIVPVKCDDQ--MI 132  Schistosoma m...
XP_002114932  127 SFNLETEYA-RLtag----------------------------srdFRVL-EVNKGFKICSSYPERCLVPSSVNEN--II 174  Trichoplax ad...
XP_002073814 1153 ersyvqDWK-RL-----------GFdaes--------------qrgFRIS-NANANYALCRSYPAIIVAPVQCSDA--TM 1203 Drosophila wi...
4Y7I_B         56 -VGSSKFRSKERVPVLSYL-YKENNAAICRCSQP----LSGF-------------------------------------- 91   human
Q7KSP6       1190 -MHLGRCFKGQRIPLPTWR-HA-NGALLIRGGQPnsksVIGMlknttgs------------------------------- 1235 fruit fly
XP_012060555  248 -TDAARHFQGNRPPVWSWTsSHG--AALVKMSEL----LPTI-------------------------------------- 282  Atta cephalotes
XP_002110574  269 nMLLAAYREK-RYPVPCWY-YQTNDVYLLRSASE----DHGLrencnemegrifgiikdpnk------qkpfktielanr 336  Trichoplax ad...
XP_012812016  198 -QKAAAFRQAGRFPVLSYY-HSANQTALLRSAQP----LFGTa------------------------------------- 234  western clawe...
XP_007257641  193 -IKAARFRQGGRFPVLCYC-HHRNSMVIMRSSQP----LTGAn------------------------------------- 229  Mexican tetra
XP_015204268  175 -RRAARFRQGGRFPVLSYY-HRKNGKVIVRSSQP----LTGAn------------------------------------- 211  spotted gar
CCD80361      133 -IESSRFRHGGRFPLLLYY-HKPRQTTLLITAEP----LINQstitnnqnttpllssnssltsstksnnliinsssknsi 206  Schistosoma m...
XP_002114932  175 -CKSAKFRYLGRFPIVSYIyHA-KKAVLMRSSQP----LSGPn------------------------------------- 211  Trichoplax ad...
XP_002073814 1204 -THLGRYFKGQRIPLPTWR-HQ-NGALLIRGAQPnsksVIGMlknttgantmth-----------------------hhh 1257 Drosophila wi...
4Y7I_B         92 --------YTRCVDDELLLEA--ISQTnpgS------------------------------------------------- 112  human
Q7KSP6       1236 -ttnahhdVTHYPEQDKYFLA--LINT---Mpkltplalnqysgmnlsmsslmghsssddrqpltpelsrkhknnldisd 1309 fruit fly
XP_012060555  283 ---------TERMQENIMFEN----------------------------------------------------------- 294  Atta cephalotes
XP_002110574  337 fpnylatvWQRIYTDNGIVRV----------------------------------------------------------- 357  Trichoplax ad...
XP_012812016  235 --------PHHCKHDEALLNAa-LMEQ----------------------------------------------------- 252  western clawe...
XP_007257641  230 --------RKRCREDELLLQAv-IDES----------------------------------------------------- 247  Mexican tetra
XP_015204268  212 --------RRRCREDELLLQAv-MDGS----------------------------------------------------- 229  spotted gar
CCD80361      207 lpfsstfnTGRCRSDEQLLSCi-LPDK----------------------------------------------------- 232  Schistosoma m...
XP_002114932  212 --------ELRCKEDEKLLNAaiFGP------------------------------------------------------ 229  Trichoplax ad...
XP_002073814 1258 hhlhhphdVSHYHEQDKYFMA--LINT---Mpkmalnqysglnlsmssllghgedhhahh-----------hhhhaqqpm 1321 Drosophila wi...
4Y7I_B        113 --------------------QFMYVVDTRPK----LNAMANRAAGKGYENEDN-YANIRFRFMGIENIHVMRSSLQKLLE 167  human
Q7KSP6       1310 gnkssqggkggtmkgnpknsLAHPFRKMR------LYALGEKSQAKSNMNVDFcAD---FIPVDYPDIRQSRPAFKKLIR 1380 fruit fly
XP_012060555  295 ------------------------VRKSHPQkippVVIELNKEI----------------------NVKLIAASFTKFIN 328  Atta cephalotes
XP_002110574  358 -----------------------------------GNVIQPKELSSGYNNLKY---------------HCLKGSDRKYWN 387  Trichoplax ad...
XP_012812016  253 --------------------SSGFIIDTRSA----QEAKQARNEGGGTESKSR-YRNWRVLHRPLERGHALQDSLVRLVV 307  western clawe...
XP_007257641  248 --------------------EMGYVVDTRSA----QQAQQARMTGGGFESKSC-YQNWKRLHRHMERGKVLQESLIKLVE 302  Mexican tetra
XP_015204268  230 --------------------ERGYVIDTRSP----QLAQQARVTGGGFESKSN-YCNFKRLHRHLERGKALQESLIKLVE 284  spotted gar
CCD80361      233 --------------------CRGVILDLRTQ----NETKKPQATSGLVEFEQY-YPQWRRVCRPLESTGNLIVTFRKFIY 287  Schistosoma m...
XP_002114932  230 --------------------KHCYIVDTRLT----NYATNIKNKGGGVEPSCY-YPQWHRIHRGIENYNSLKDSLTKLVE 284  Trichoplax ad...
XP_002073814 1322 tpevtrkhegksstmkgtsaAPLGFRKMR------LYALGEKSQAKSNLNGDFcAD---FIPVDYPDIRQSRSAFKKLIR 1392 Drosophila wi...
4Y7I_B        168 -VCel-----ktPTMSEFLSGLES-----SGWLRHIKAIMDAGIFIT---KAVKvEKA---SVLVHSSDGWDRTAQVCSV 230  human
Q7KSP6       1381 -ACmpsh-ntneADGQSFAKMVEQ-----SDWLQQISSLMQLSGAVV---DLIDlQES---SVMLSLEDGSDVTAQLSSI 1447 fruit fly
XP_012060555  329 -LCtpenirqfwIQDNNFYSLLEN-----TKWLKYISYCLQKTVEVC---DHLNlGI----SVILQEGAARDLCCVISSL 395  Atta cephalotes
XP_002110574  388 -------------SDKDWFASLAA-----TQWPNFIRVCLFIATKIA---DKLHyGAV---SILVKDYDGAELSCVICSL 443  Trichoplax ad...
XP_012812016  308 -TCyd-----psIGMTRWLSKLQA-----ARWLSHVKEALSTAGLIA---ECIErECA---NVLVHGEDGTDNTLLLTSL 370  western clawe...
XP_007257641  303 -ACgd-----psHNMDRWLSKLEN-----SKWLTHVHSALSTAGLVA---ECVErDSH---SVLVHGSEGTDTTLLVTTV 365  Mexican tetra
XP_015204268  285 -ACtd-----qsNSTDRWLSRLES-----CRWLSHVSAALVAAGLLA---ECVErEGC---SALVHGSEGTDTTLLVTTV 347  spotted gar
CCD80361      288 aAVag-------------aTALDAldafaQQQLQQEQCLLAEKQRRAskdQSLEeAKLrgsCVIVQSRKGTDRAILVASL 354  Schistosoma m...
XP_002114932  285 -ATsd-----fdCSSSAWLSRVSS-----SNWLNHVRSILNTACFVI---GYLFdEGA---TVLVHGSDGMDATLQITSL 347  Trichoplax ad...
XP_002073814 1393 -ACmpsh-iandADGQSFAKMVEQ-----SDWLQQISSLLQLAGAVV---DLIDlQES---SVMLSLEDGSDVTAQLSAI 1459 Drosophila wi...
4Y7I_B        231 ASILLDPFYRTFKGLMILIEKEWISMGHKFSQRC----GHLD----GdSKE--VSPIFTQFLDCIWQLMEQFPCAFEFNE 300  human
Q7KSP6       1448 AQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSnlkpSHANtn-------iaFAPTFLQFLDVVHQLQRQFPMAFEFND 1520 fruit fly
XP_012060555  396 AQLLLDHHFRTIVGFQSLLQKEWVAGGHPFCDRL----GHIVkt----nsE--KSPLFLLYLDCVWQLCQQYPTEFEFTE 465  Atta cephalotes
XP_002110574  444 VQVILDGDCRTIKGFQTLLQKNWVVVGYRFNASQ-------------------ESPFFELFLSCISQLLYQNPLAFEFSP 504  Trichoplax ad...
XP_012812016  371 AQLILCPESRTMDGFQDLIEREWLQAGHPFQLRC----AQSGw--sQ-SRAqqESPHFLLFLDCCWQLGRQFPRALEFNE 443  western clawe...
XP_007257641  366 AQLILDPASRTFRGFLELLEKEWVQAGHPFQLRC----ARSAy--sH-ARLrqECPSFLLLLDCVWQLWRQFPLALEFSE 438  Mexican tetra
XP_015204268  348 AQLILDPRCRTFGGFLALIEREWLQAGHPFQQRC----AHSAl--sH-ARPrhEAPTFLLLLDCCWQLCRQFPLALEFSE 420  spotted gar
CCD80361      355 IQIILNPESRTIQGFQTLIDQTWLNAGHPFSDRC----RNSAfsikP-PKD--ESPVFILFLDCVWQLLRQYPNSFEFTD 427  Schistosoma m...
XP_002114932  348 AQIMIDQDCRTIRGFQALIEREWLLGGHPFSSRC----SKLC----N-TQDisTSPVFLLFLDCVWQLQQQHPCFFEFNE 418  Trichoplax ad...
XP_002073814 1460 AQLCLDPYYRRLDGFRVLVEKEWLAFGHRFAHRSnlkpSHAStn-------iaFAPTFLQFLDVVHQLQRQFPMAFEFND 1532 Drosophila wi...
4Y7I_B        301 NFLLEIHDHVFSCQFGNFLGNCQKDRE 327  human
Q7KSP6       1521 FYLRFLAYHSVSCRFRTFLFDCELERS 1547 fruit fly
XP_012060555  466 TYLTTLWDAAHVSIFDTFIFNCERDRA 492  Atta cephalotes
XP_002110574  505 NYISHLLDISLCGLTETFSYNNEYERC 531  Trichoplax adhaerens
XP_012812016  444 RFLCTLATHAYSSEYGSFLCNNEKERC 470  western clawed frog
XP_007257641  439 ALLLRLAQEAYASDYGTFLCNNEQERG 465  Mexican tetra
XP_015204268  421 ALLLRLAREAYASNFGTFLCNSEKERC 447  spotted gar
CCD80361      428 ELLCIIAKHAYFSEYGTFLGNSLQERE 454  Schistosoma mansoni
XP_002114932  419 EFLRVLGHKAYSSEFGTFLYDSHAQRL 445  Trichoplax adhaerens
XP_002073814 1533 FYLRFLAYHVVSCRFRTFLFDCELERS 1559 Drosophila willistoni
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