pfam06870: RNA_pol_I_A49 (this model, PSSM-Id:311058 is obsolete and has been replaced by 462024)
A49-like RNA polymerase I associated factor
Saccharomyces cerevisiae A49 is a specific subunit associated with RNA polymerase I (Pol I) in eukaryotes. Pol I maintains transcription activities in A49 deletion mutants. However, such mutants are deficient in transcription activity at low temperatures. Deletion analysis of the fusion yeast homolog indicate that only the C-terminal two thirds are required for function. Transcript analysis has demonstrated that A49 is maximising transcription of ribosomal DNA.
Jiyao W et al.(2023). "The conserved domain database in 2023.",