1RGX,1RH7


Conserved Protein Domain Family
Resistin

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pfam06954: Resistin (this model, PSSM-Id:311105 is obsolete and has been replaced by 399733)
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Resistin
This family consists of several mammalian resistin proteins. Resistin is a 12.5-kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralisation of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes.
Statistics
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PSSM-Id: 311105
View PSSM: pfam06954
Aligned: 32 rows
Threshold Bit Score: 92.741
Threshold Setting Gi: 156386180
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RGX_C        24 PLCPIDEAIDKKIKQDFNSL-FPNAIKNIG--------LNCWTVSSRGKLASCPEGTAVLSCSCGSACGSWDIREE-KVC 93  house mouse
XP_008102432  30 QRCPVEDAIDAKISAAIDSK---VSILVPE--------LSCTSVSARGADVSCPSDYKATGCACGMACGSWDIRGE-TQC 97  green anole
XP_007656086  22 TQWILDTDVIEKIQERVNSL-VSSALKDLS--------LVCTSVFTQGALVACPSGYKATACSCGSACGSWDIRSD-TVC 91  platypus
XP_016846768  23 ACCSIDRAIDAKIKAAVDSK-VSATLAKSQ--------LTCTTIKTSGALAACLHGYTVTGCSCGKACGSWDVRDN-STC 92  green anole
XP_003763615  41 SKEDLDAIVQKKVNEAFSKLeTGN---KRT--------LSCISVKSGGTLATCPAGFVVTGCACGYGCGSWDVRRD-NTC 108 Tasmanian devil
XP_001633834  24 EEGEDETALEGTAVEDEEPVsDPEAIVSRKwhlwrkgrLHCLSVSSKGNTAACPAGYLVTGCACGYACGSWNPEANgTRC 103 starlet sea ane...
XP_001363505  46 ADCALDSIVDKKIKESLTSLeLGF---QAR--------LTCTSVKSRGTLATCPAGFIVTGCACGYGCGSWDVRGD-NVC 113 gray short-tail...
ELV12719      31 SQCSLDSMVDKKIKEALNSLeFNPSVLT-K--------FSCTSITSSGRLASCPAGMSVTGCACGYACGSWDVQSE-TTC 100 Chinese tree shrew
XP_006090150  23 TQQSLDAIVDEKIKDAIQSLeCNPPPPT-R--------ISCTSVTNSGKLSSCPPGTFVTGCACGYGCGSWDIRRE-TTC 92  little brown bat
NP_001096680  23 SQCSLDSLVDKKIKDALNRLeLNPSAPRKR--------ISCFSVKNSGKLSSCPAGTVVTGCACGYACGSWDVQHE-TTC 93  pig
1RGX_C        94 HCQ--C----ARIDWTAARCCKL 110 house mouse
XP_008102432  98 HCQ--C----ANIDWTSARCCKV 114 green anole
XP_007656086  92 HCQ--C----RGIDWTSARCCQI 108 platypus
XP_016846768  93 HCQ--C----ANVDWTAARCCKI 109 green anole
XP_003763615 109 HCQ--C----RA--WTGpvldaa 123 Tasmanian devil
XP_001633834 104 FCHkgCmpngQSLDWTLAMCCKV 126 starlet sea anemone
XP_001363505 114 HCQ--C----SGMDWTSARCCQf 130 gray short-tailed opossum
ELV12719     101 HCQ--C----SVVDWATARCCHL 117 Chinese tree shrew
XP_006090150  93 HCQ--C----SVVDWTTARCCQL 109 little brown bat
NP_001096680  94 HCQ--C----NTADWTAARCCRL 110 pig
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