1M5I


Conserved Protein Domain Family
Suppressor_APC
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pfam11414: Suppressor_APC (this model, PSSM-Id:314370 is obsolete and has been replaced by 463275)
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Adenomatous polyposis coli tumor suppressor protein
The tumor suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Links
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Statistics
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PSSM-Id: 314370
Aligned: 31 rows
Threshold Bit Score: 63.8002
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1M5I_A          2 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTEn--fSLQTDM-TRRQLEYEARQIRVAMEEQ 78   human
XP_011414933  320 DYNMIKRMKQLEQEKDSLLKGLEMVDQAREWYHRQVLGVEDKQKYIGHTSy--nDYNLEA-NQERMNFQNARIMEVNQQL 396  Pacific oyster
XP_015781886  451 DINTIKRLQQYEQEKEILLQGLEMIERGRDWYIKSINTIQNKIRFIGQTMvnqgDYSLDA-NQERINFQAARILTVNQHL 529  two-spotted s...
EFX73731      309 DQSMLRRIHILEQERQVLTSGMQALDKARDWFNSQLIDVNERIKSFGKSSigssDYSTDA-ASERLGFKISRIEEVSRQL 387  common water ...
XP_003728145  174 DYNMLKRMKQLEQERDIFLQGLEALELARDWYRQQLASIRDRQDRINKaq---vDFTEDIdHQDMVVYRTTRITELNRQL 250  purple sea ur...
XP_002131251  555 DYNVLKLIQQLEQEKDVLLQGLDALERGRDWFQERISDVQEKQRLLSNNGm---KPTRDV-TENDATVTQSRIDNLLTKV 630  vase tunicate
XP_006171828  131 SRATIRLLEELDRERCFLL-----EEKEKLWYYSQLQGLSKRLDELPHVEtq-fSMQMDL-IRQQLEFEAQHIRSLMEER 203  Chinese tree ...
XP_015220786  189 grvtAQHLEDLCKERTLLLSEIEKEERERRWYYSQLQGLSQRLAELPRVEt--fSMQMDL-IRQQLEFEAQQLRSVMEER 265  spotted gar
XP_011472584  184 grlsDHHLEELYKERNLLLGEIDREERERCWYFSQLEALSQKLSQLPRIDt--fSLQMDL-IRQQLEFEVQQVRSVMEER 260  Japanese medaka
XP_009075736  102 sRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTEn--fSLQTDM-TRRQLEYEARQIRAAMEEQ 178  rifleman

1M5I_A         79 LGTC 82   human
XP_011414933  397 KTLI 400  Pacific oyster
XP_015781886  530 AALM 533  two-spotted spider mite
EFX73731      388 LVLI 391  common water flea
XP_003728145  251 RALI 254  purple sea urchin
XP_002131251  631 SEMS 634  vase tunicate
XP_006171828  204 FGTS 207  Chinese tree shrew
XP_015220786  266 FGTS 269  spotted gar
XP_011472584  261 FGSS 264  Japanese medaka
XP_009075736  179 LGTC 182  rifleman
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