Conserved Protein Domain Family
SBF2
?
pfam12335: SBF2 (this model, PSSM-Id:315091 is obsolete and has been replaced by 463536)
Myotubularin protein
This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with pfam02141, pfam03456, pfam03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease.
Links
?
Statistics
?
PSSM-Id: 315091
Aligned: 25 rows
Threshold Bit Score: 298.437
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q177S0        492 PPM-PLIDSQeVQVNNSARKLEVLKNCISCIFDNKITEARKSFPAVLRILKQRDARLTLCRELAKIAHGNKQ-LDHQQFD 569  yellow fever ...
XP_002107707  568 MKLtGAL---------MLKRLEVLRKCVSNIFNNRIIEAKKMFSAVLSLLTSVQYRIALVEEFESYCLHSRVvLTFDQFD 638  Trichoplax ad...
XP_010136857  146 PPIaAIMERNgNALANSARRLEVVRNCISYVFENKMLEAKKLFPAVLRAMKGRAARHCLTQELNLHVQQNRAvLDHQQFD 225  Buceros rhino...
XP_016873866  531 PPVvSIMDKVtTVF-NSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAiLDHQQFD 609  human
XP_014329209  535 PPVvSIMGKCgSVF-NSARRLEVVKNCISFVFDNKTLETEKSLPAALRALKGKAARQCLTDELSVHVQQNRAiLDHQQFD 613  southern plat...
XP_015457043  569 PPVvSITGKAsCVF-NSARRLEVVRNCIGFIFENKTLETEKALPAALRALKGRAARQCLTEELSLHVQQNRAiLDHQQFD 647  Mexican tetra
XP_015193813  487 PAVvSIMAKTgSVF-NSARRLEVVRSCIAFVFDNKILETEKTLPAALRALKGKAARHCLTEELSLHVQQNRAlLDHQQFD 565  spotted gar
XP_005989750  530 PPVvSIMDSTgPVF-NSERRLEVVRNCISFIFENKILETEKTLQAALRALKGKAARVCLTQELNKHVQQNLTlLDHQQFD 608  coelacanth
XP_002603640   81 VPCgENRRDKfSGLNSSARRLEVMRNCINYIFDNKIQEAKKSFPAVLRGLKSKVTRLALCDELSLHMQQNRVvLENHQFD 160  Florida lancelet
XP_011670495   73 nasigNFEGHrNLVNNSARRLEVLRTCINFIFENKILDARRLFPAVMRSLKSRVARQALLHELELHVNKNRAmLEPQQFS 152  purple sea ur...

Q177S0        570 LVVKLMNRALQDDSSKDEYGVAAALLPLSTTFCRKLCTGVIQFAYTCIQDHPVWKNQQFWEDAFYHDVQNFIKELYLPRQ 649  yellow fever ...
XP_002107707  639 MVVRLINQALQEDDANDRNGVAAMILPFSASFCRKLSDNVHQFAYTCVWDHPVWDNPRFWERTFYLTCQKHVMNLYENSL 718  Trichoplax ad...
XP_010136857  226 FIIRMMNCCLQDCTAMDEHGIAAALLPLVTAFCRKLSPGITQFAYSCVQEHVVWTNIQFWEAMFYCDVQNHIRALYLDNN 305  Buceros rhino...
XP_016873866  610 YIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAK 689  human
XP_014329209  614 YIVRMMNCALQDCSTSEEFTVAAALLPLSTAYYRRLAAGVNQFAYTCIQDHPIWTNQQFWEATFYSEVQSQIRSLYLNTP 693  southern plat...
XP_015457043  648 HIVRMMNCALQDCSNSEEYTVATALLPLTTAFYRKLGPGVNQYAYTCVQEHPIWTNQQFWEATFYSEVQNQIRALYLNSP 727  Mexican tetra
XP_015193813  566 YIVRMMNCALQDCSSSEEYTVAAALLPLTTAFYRKLAPGVNQFAYTCVQDHPIWMNQQFWEATFYSEVQNQIRALYLTTL 645  spotted gar
XP_005989750  609 YIVRMMNCALQHCSSSEEYTVAAALLPLTTAFCRKLSPGINQFAYTCVQDHPVWTSQQFWEAAFYSDVQCQIRALYLAAK 688  coelacanth
XP_002603640  161 MVVRLINCALQDCSSMDEHGVAAGLLPLVCAFCRKLAPGVMQFAYTLVQDHPVWANLQFWEASFYTDVQKHIKELYHQPD 240  Florida lancelet
XP_011670495  153 MVVRLINAALQEDSHSEEFSLSMDFLPLISAFCRKLCPGIIQFAYTVTQDHPVFASHAFWETAFYADVEKNIQSLYVTPD 232  purple sea ur...

Q177S0        650 TSEKSY-------------------------SSWATDTNAQEPSALEIAADQMRIWPTVDLDKQTELTSSEEKTLYSQAI 704  yellow fever ...
XP_002107707  719 IKKANKn-----------------------aIEAKNDNKVEDVTAVETV--------ETAINTDTENGKPKAETTFGTT- 766  Trichoplax ad...
XP_010136857  306 EENHTDees--------------------------pegPQEAKSALEIASEQLRLWPTMSREKQQELIQKEESTVFSQAI 359  Buceros rhino...
XP_016873866  690 EDNHAPhlk---------------------qkDKLPDDHYQEKTAMDLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAI 748  human
XP_014329209  694 EEKRAItatpkvr------------nkhdadPQSAAG-SGDEQTAMDLAAQQLRLWPSLSKDKQQELVKNEENTVFSQAI 760  southern plat...
XP_015457043  728 ADKPLItarl-----------------kepgPLPPAAPSESERTAMDLAAEQLRAWPSLDKEKQAELVKSEESTVFSQAI 790  Mexican tetra
XP_015193813  646 EGKPGIsmk--------------------lkERGPAA-QDLERTAMDLAAEQMRAWPALSKEKQQELVQNEESTVFSQAI 704  spotted gar
XP_005989750  689 EDTPGInlk--------------------qkGT----TGLEQKTAMDLAAEQLRLWPSLSKEKQQELIQSEESTVFSQAI 744  coelacanth
XP_002603640  241 RNGKVPssp--------------------gmRRRVEVNRSLEKSALDIAAEQLRLWPHRSKDDQQELVNNEESTVYSQAI 300  Florida lancelet
XP_011670495  233 NTPTYEkkdvsqsfndafaagpdasgssassAAANGLITSAERSPLDIAAEQLRLQPNMNHDAREEAKSNEESIVYSQAV 312  purple sea ur...

Q177S0        705 HYANRM 710  yellow fever mosquito
XP_002107707  767 -----L 767  Trichoplax adhaerens
XP_010136857  360 HYANRM 365  Buceros rhinoceros silvestris
XP_016873866  749 HFANLM 754  human
XP_014329209  761 HYANLM 766  southern platyfish
XP_015457043  791 HYASLM 796  Mexican tetra
XP_015193813  705 HYASLM 710  spotted gar
XP_005989750  745 HYASLM 750  coelacanth
XP_002603640  301 HYANRM 306  Florida lancelet
XP_011670495  313 HYANRM 318  purple sea urchin
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap