Conserved Protein Domain Family
TC1
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pfam15063: TC1 (this model, PSSM-Id:317478 is obsolete and has been replaced by 464478)
Thyroid cancer protein 1
Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.
Links
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Statistics
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PSSM-Id: 317478
Aligned: 10 rows
Threshold Bit Score: 90.1949
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007238793   4 YASSESRRVTPRVHGSGFDTARRKRAAPHIFEQVREDALVRLFRKAGDAKAEERARSVFaaaASHEPGETARALMAL 80  Mexican tetra
XP_003339703  23 SIMSTSLRVSPSVHGYHFDTAARKKAVGNIFENIDQESLQRLFKNSGDKKAEERAKIIFs--IDQDMEEKTRALMAL 97  gray short-tailed ...
XP_002936483  37 mGTPASVVSSPSAPWQAPVARSRKKASANIFKDINLLQIQTLFHTSGDECAEERARIIC---EYAGDKHVADALIrl 110 western clawed frog
XP_016383802   4 YASSNSRRVSPAVSGVKFDTAHRKKASPNIFENVNQDVLVKLFEKAGDLKAVERARSILa--LHQDPEGISKALMAL 78  Sinocyclocheilus r...
XP_005806654   4 YMSSESRRVSPSAHGNKFDTAHRKKAVANIFENVNQDSLMRLFQKTGDMKAEERVRSIFs--YTQDPEETARALMAL 78  southern platyfish
XP_014325207   6 ASASPSVVASPSSLWRLAERRNRKSGSGNIFSTVNLWQLQRLFRAAGDEDAEQRAQLVW---GHRDEAELAKALVAL 79  southern platyfish
XP_015201894   5 aapAAAAPASPSQLWRLSGRRSRKAASPDIFRGVHLRQLQRLFRRSGDQQAEQRAQLVW---GRSDAAGLAQALTRL 78  spotted gar
XP_851002      1 mGTPASVVSEPPLWQAPAEARGRKQASANIFQDAELLQIQGLFQRSGDQLAEERAQIIW---ECAGDHRVAEALRRL 74  dog
XP_001232955  10 SAMSTSLRVSPSVHGYRFDTALRKKAVANIFESVDEESLQKLFKHSGDKKAEERAKIILd--TDQDVEEKARALMAL 84  chicken
XP_004468749  10 SIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENIDQESLQRLFKNSGDKKAEERAKIIFa--IDQDLEEKTRALMAL 84  nine-banded armadillo
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