Conserved Protein Domain Family
MREG

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pfam15812: MREG (this model, PSSM-Id:318106 is obsolete and has been replaced by 434956)
Melanoregulin
Melanoregulin is a family of proteins found in eukaryotes. It is a putative membrane fusion regulator. MREG forms a complex with peripherin-2. It is required for lysosome maturation and plays a role in intracellular trafficking. It is a negative regulator of melanosome intercellular transfer and it regulates intercellular melanosome transfer through palmitoylation.
Statistics
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PSSM-Id: 318106
Aligned: 12 rows
Threshold Bit Score: 206.82
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0P4L7        41 VIDDDERNLWSSPHDLSHTEAVDDRMLQSWIQTRNQLEKDSEEWQKLNYEIYTLRQARREVRARWRRILEDLGFQ--KEA 118 tropical clawed...
Q6GQM0        44 KRRDQETNLWSEPGDPSHSERDDDRVLYKLLQCRQQTQPGSRGYRRLSIDIEAMRDVRREVRDKWKMILENLGFM--AEA 121 zebrafish
XP_006009036  40 VRWDEERNLWSTPHDSSHTEADDDRELYNLIVTRDQLDQDSEEWQKLNYDIHALRQCRREVRNRWRKILEDLGFQ--KEA 117 coelacanth
XP_006638281  43 RRRAEETNLWSEPADKSHTERDDDRELYNLLHRRAKTRRGSQGYRRLSVDIHAMRQVRRGVREKWKMILENLGFM--AEA 120 spotted gar
XP_005994095  40 RRRAEETNLWSEPHDKTHMERDDDRELYNLIHRRAKTRRGSEGYRRLSFDIHALRQVRRDVKDRWKMVLENLGFR--NEA 117 coelacanth
XP_002940422  39 RRRAEEANLWNEPQDVSHTERDDDRELYNLLQKRSKTRRGSEGYRRLSFDISAHRQIRKDVKDRWRVLLENLGFS--NEA 116 western clawed ...
XP_006636897  38 TQRAEDWNLWSSPQDSSHTESDDDRELYNLLIMRNEVDKNTEVWEKLNYDIHTFRYIRREVKARWKKILLKLGFQ--KEV 115 spotted gar
XP_002613025   8 RLKDDDLNIWHDPQDRTHMETDEDLELYNLIRRRDECPRGSDEWSHLNFDIHTVRTRRREIRDRWVKILEMLGFDdlQEI 87  Florida lancelet
XP_008111538  38 KRKAEAENLWNEPVDSTHMERDDDRQLFTMLQKRSKLRRGSEGYRRLSIDIIAQRQIRQKVKDRWKHVLDALGFK--NEA 115 green anole
XP_011602536  43 KRRDEEANLWSTPGDPSHSEREDDRVLYSLLQARNKTRMGSSGYRRLSVDIEAMRDTRREVRDKWQTILENLGFM--AEA 120 torafugu
XP_003254098  44 lVRDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEEWQKLNYDIHTLRQVRREVRNRWKRILEDLGFQ--KEA 121 northern white-...
XP_012957092  21 lARDEEQNLWSTPHDVTHTEADDDRVLYNMIVGRSQLDKDSEEWQKLNYDIYTLRQTRKEVRSRWKHILEDLGFQ--KEA 98  mallard
Q0P4L7       119 ETLLSVTKQSTISNPKNMKRAMELLVKLSDNTTIF--PAGWDLPVRYLYIMDRLICLDAVDDFLNIAQKKYP 188 tropical clawed frog
Q6GQM0       122 ESLLNVSASASYDRMRNAASARSLLQTLHTETSLF--NSKEPPPERYLFILDRLIYLDAAEDFVAKARRFYP 191 zebrafish
XP_006009036 118 DSLLSVTKLSTVGNSQNLNQTRELLLKLAEETSIF--SNNGGLPERYLFVLDRLISLDAAEDFLKTASKRYP 187 coelacanth
XP_006638281 121 ESLLTVSSSTTYANLRYATTARSLLQALHQDTSIF--DSKGAPPERYLFVLDRLIYLDAAEDFVDKARRFYP 190 spotted gar
XP_005994095 118 ESLLTVTSNTPYNSMKNASEAKKLLETLAEETSIF--DDDSDPPDRYIFVLDRLIILDVAQDFLFKSRCYYP 187 coelacanth
XP_002940422 117 DSLLTVTSNTSYKSLRNPAEARHLLSLLAQESSIF--EQQSIPPERYLFVLDRLIVLDMGTEFVSIARRFYP 186 western clawed frog
XP_006636897 116 DTLLSVNKQSTLSDSGNFTKAREYLSKLLEETSLF--PKGCEAQERYLIVMDRLVSLDSAEDFLKLAMKKYP 185 spotted gar
XP_002613025  88 DNILTVTAVTKETISQG---AKDLFNELSEESSIF--GVSSTKPARYLYVLERLIHIDLAQTFVETAKQLYP 154 Florida lancelet
XP_008111538 116 DGLLTVTSGTSYESLRKPQEARKLLNFLAEQTTIFgrNRGTGPPERYLFVLDRLLLLDIGDDFLSAARHFYP 187 green anole
XP_011602536 121 ESLLNVSAGASHDRMRNAPAARAMLNKLHSETSIF--SNKEPPPERYLFILDRLIYLDIADDFMAKAKRFYP 190 torafugu
XP_003254098 122 DSLLSVTKLSTISDSKNTRKAREMLLKLAEETSIF--PTSWELSERYLFVVDRLIALDAAEEFFKLARRTYP 191 northern white-cheeked ...
XP_012957092  99 DSLLSVTKLSIISDSQNMGKARDILLKLSEETNIF--PTSWQLSERYLFVVDRLIALDAADEFFKMASVVYP 168 mallard
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