Conserved Protein Domain Family
MISS
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pfam15822: MISS 
MAPK-interacting and spindle-stabilising protein-like
MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.
Links
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Statistics
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PSSM-Id: 318115
Aligned: 3 rows
Threshold Bit Score: 156.3
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004055249   5 FSLADALPEHSPAKTSAVSNTK----PGQPPQGWPGSNPWNNPSAPSSVPSGLPPSATPSTVPFGPAPTGMYPSVPptgp 80 
XP_005047825  15 FSLADALPDQSPAKTSKVSSSKpgqqPGQPPQGWPASNPWNNPSAPPMTPTGLPPNTSASSVPFGPPPTGMYPSMP---- 90 
EGW13560      17 FLLAYVLPEQSPARTFAVSNPK----AGQAPQGWPGSNPRSNLSAPPAVLSGLSPSTAPSTLPFGPAPTGIYPSIPltgp 92 

XP_004055249  81 pPGPPAPF--PPSGPSCPPPGGPYPAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAA-AGPLGPWGSMSSGPWAPGM 157
XP_005047825  91 -PGPPAPFppPPTGPSCPPPGGPYPPPTVPGPVPPGQYPPPNMPFPELPRPYGGPTEPAApPAPVGPWGSMPSGAWGPTM 169
EGW13560      93 sPGSPPPF--LPSELSCPQPSGPYPAPVVRGPGPIGPYATPNMHLPELPRQYGAPTDPAA-AATSGTRGSMSSGPWAPGI 169

XP_004055249 158 GGQYPTPNMPYPSPGPYPAppPPQAPGAAPPVPWGTVPPGAWG--PPAPYPAPTGSYPTPGLYPTPSNPFQVPSGPSGAP 235
XP_005047825 170 GGQYPAPSMPYPPPGPYSA--PTQTPGAAPTVPWGTVPPGTWGpsPPGPFPPPTGSYPAPGLYPTPPNPFQVPSGPAGAP 247
EGW13560     170 GGQH--PNVPYRSPGPHPTvpPPVS--GAPPVPWGTVPPGPWG--PPAPYPDPEGSYSMPGPHPTLNNPYQVTSGPSGTP 243

XP_004055249 236 PMPGGPH 242
XP_005047825 248 SMPGGPH 254
EGW13560     244 PIPGDPR 250
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