Conserved Protein Domain Family
DUF4757
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pfam15949: DUF4757 (this model, PSSM-Id:318215 is obsolete and has been replaced by 464950)
Domain of unknown function (DUF4757)
This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 145 and 166 amino acids in length. The family is found in association with pfam00412. There are two completely conserved residues (W and L) that may be functionally important.
Links
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Statistics
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PSSM-Id: 318215
Aligned: 38 rows
Threshold Bit Score: 96.3231
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q172S7         41 MSTDKEGIVSPPSKRNDVAYsiNSYE---------DTRNANITMSYDpteyIQKARVTRAQPPKPAYDPLqfvQ------ 105 yellow fever m...
28_pfamImport   1 MSTSATStngsd-------------------tngcGGRKSSITSPDPts-yVTKARVTKPTPPPPSKNPMqfvQ------ 54 
36_pfamImport   1 MLVRKLGGVQPHTSVPVTIPvp------------tTCSEEDLQKWKA----IQE-------ASRQRHKKKlmvKrllek- 56 
1_pfamImport    1 MLLRKLRALNTQGTEgrkaa-----------gvslSCSEDDMQKWQA----IRE-------ASRVRYRKRlmvErlfqk- 57 
35_pfamImport   1 MLVRKLRMMQVQGTCSPSGAgqGSSVtqtgpsipsSCSEEDLRKMQA----IRE-------ASRLRYKKRliaErlglh- 68 
6_pfamImport    1 KEYRRSQVIAPKTTTQFNQF--LPSRdkqsgyvpaPLRKKRAERNED----SRRSW-----ASPMFTEDDgtfTrlfqk- 68 
22_pfamImport   1 ISYRRSVSITPKATAPFNQF--LPSKdkssgyvpaPLRKKRAERNED----IRHSW----TSASTELGGVvlfDryhead 70 
31_pfamImport   1 LSYRRSLVITPKSSGQFNQF--LPTKdkqsgyvpaPLRKKRAERNED----SRRSW-----ASSSFAEDEatlTrqqqt- 68 
8_pfamImport    1 LYARRVLVSEHQTSINANSDkfLPKFwtpee--dlhvRKIRLGSQR-------RPWYKKMQG------------------ 53 
7_pfamImport    1 HFFRMAESSKSGAPireka------------hvpaVLRKKRQDYQQ-----GSRSYAGHL-------------------- 43 

Q172S7        106 ------LKPCSLVKT-------------------------AQAQ----------MQKADEVKKVKDEKKEEPEEWQCNLD 144 yellow fever m...
28_pfamImport  55 ------IKPCNLYQT-------------------------AQQQl----------kKAEEVKKLKEVQKEEPEEWQNNLD 93 
36_pfamImport  57 --hsggNGSKSMNDV-------------------------TQDTei------trQIRFEGLQKLRTQIKESDNKWQDDLA 103
1_pfamImport   58 --nsdsEGSKSVSDI-------------------------TESEmsn----stmELRLEELQKMRNRLKESEDKWQDDLS 106
35_pfamImport  69 --liqqQGSKSIGDI-------------------------PIEQvt-------kQVQYEQLQKFRDQVKESEDKWQDDLS 114
6_pfamImport   69 --nsdsEGSKSVSDI-------------------------TESEmsn----stmELRLEELQKMRNRLKESEDKWQDDLS 117
22_pfamImport  71 pcttlfSSAEETSII-------------------------IAAClddlp-vdagARRYEQLQNFRDQIKESESQWQDDLS 124
31_pfamImport  69 --qessDGSKSTSDI-------------------------QVDPsi------mrQNRFEELQKYREQIKESEDRWQDDLS 115
8_pfamImport   54 ------LRSKSMGDItlepipqesdnsssfdslgplhvhqRSDEelsldpsalqRVQYEQLQHIRQRMKENEAKWHEDLS 127
7_pfamImport   44 ------TRSKSMGDItlepipqesdnsssfdslgplhvhqRSDEelsldpsalqRVQYEQLQHIRQRMKENEAKWHEDLS 117

Q172S7        145 NWKSSRRKRVEHIIDRVVEVKKFEL----EEHDRNRRKSKTFNEMMEE 188 yellow fever mosquito
28_pfamImport  94 NWKSSRRKRVEHIIDRVVETKKLEL----EEHDRTRRKSKTFTEMMEE 137
36_pfamImport 104 KWKSRRKSFNNDLVKKMAEREEIELltstD---T-ERKTKTFREMQEE 147
1_pfamImport  107 RWKSKRRSVNSDIVKKKEEREQIEQitsvG-----TRKSKTFKEMQDE 149
35_pfamImport 115 AWKNRRRSVNSDIMKKKEEREQIEVltsgS---S-TRKSKTLREMAEE 158
6_pfamImport  118 RWKSKRRSVNSDIVKKKEEREQIEQitsvG-----TRKSKTFKEMQDE 160
22_pfamImport 125 KWKNRRRSVNSDIVKKKEEREKIEQitssD---NYSRRSKTFREMQDE 169
31_pfamImport 116 KWKNRRRSVNSDIVKKKEEREKIEQitygS-----DGRSKSFKEVQEE 158
8_pfamImport  128 RWKSRRRSANSDLHKKLEEREQIELittaGGASGIRTAH--LTGVPEE 173
7_pfamImport  118 RWKSRRRSANSDLHKKLEEREQIELittaGGASGIRTAH--LTGVPEE 163
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