4E4W


Conserved Protein Domain Family
Mlh1_C

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pfam16413: Mlh1_C (this model, PSSM-Id:318596 is obsolete and has been replaced by 465109)
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DNA mismatch repair protein Mlh1 C-terminus
This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site.
Statistics
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PSSM-Id: 318596
Aligned: 193 rows
Threshold Bit Score: 124.921
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4E4W_A           26 NLTSIKKLREKVDDSIH-RELTDIFANLNYVGVVDEerRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDF-----ANFGK 99   Saccharomyc...
120_pfamImport    1 LLTSVSTIVSQIRQTTS-PTVQSLFEKLVYVGVING--HMFLAQSGTTLYAVDTLRLVRLVVYQRIFMRWsiaslPAPPQ 77  
Q57TS9          623 LLTSVSTIVSNIRAGTS-QTAQSLFQNLAYVGVLKG--HLFFAQSGTTLYVVDSLRLVRHVVYQRIFLRWatpslSAVPQ 699  Trypanosoma...
109_pfamImport    1 RIQVQQQLLSLRNQDIH-DTTSSFFKNLTYVGCISSnhFLA--QFRDDLYLINSIPLCQEIFKFEILRNF-----GQIKP 72  
Q4Y1V0           29 EISSIKKLRKICEEKEK-KELTDCLKNSIYVGPVDN--IHSLIQYKEKLLMIKMPLIIKEIIYQSILNRI-----GKIPP 100  Plasmodium ...
Q8IIJ0          710 EISSIKKLKMICEEKEK-KELTECLKNSIYVGPVDN--MHSLIQYKEKLLLIKMPLIIKEVTYQSILNRL-----GKIPP 781  Plasmodium ...
21_pfamImport     1 -ISSIRKLKRICEEKEK-KELTECLKNSIYVGAVDN--LHSLIQYKDKLLMIKMPLIIKEITYQSILNRI-----GRIPP 71  
Q5CRJ3          548 TEIEIMNDNTEASKMEYlKSLTKNIINGIYIGQIKS--SWSIIQAKNQILLINIEQMSKIALKQSLICRL-----GYIPL 620  Cryptospori...
16_pfamImport     1 EFESLEILRHQIASSAS-LSLRELIKTSTFVGSIDP--ETVLIQFGTSLYMLKFSEILREFFYQISILSF-----GNYGS 72  
161_pfamImport    1 DFESLKSMKKEICANAS-IALRGLFKEHTYIGAIDP--TRALIQHSTSIYLVDSEQCFLHYFYQLLVLSF-----GNFGS 72  
4E4W_A          100 INLqstnvsDD-IVLYNLLse----fD----ELNDDA-----------------SKEK----IISKIWDMSSMLNEY--- 146  Saccharomyc...
120_pfamImport   78 MLL------EEpVRVTDLL-------C----FALQHDvppqtdvs--laestqrTVRR----MDRCLRQWRCMLLEY--- 131 
Q57TS9          700 LSF------EEpIHLSDLL-------S----FALQNDvqlppsqk-radggpgsLLSR----LGRRLCNWRYMLQDY--- 754  Trypanosoma...
109_pfamImport   73 VEL------NQaIGLKDILeyfllnfD-----EIPNEkkef----------hlsNMDT----YIEQFGLLSDFLRDS--- 124 
Q4Y1V0          101 FKF------DPpIPLYDLL-------L----VGLNNSysgffenpkyanknverVCNE----LEQIFYSYEEMYADY--- 156  Plasmodium ...
Q8IIJ0          782 FEF------DPpIPLYDLL-------L----VAVNNSysgfyenpnyankniekVCNE----LEQIFYTYNEMYSDY--- 837  Plasmodium ...
21_pfamImport    72 FKF------DPpIPLYDLL-------L----VAMNNSqsgyfenpdyvtknierICNE----LEQVFYSYEEMYADY--- 127 
Q5CRJ3          621 LKL------NPpVSLGELS-------------LFGTEsvk-----------nykLNENdqiqLKDFINSQAYLYFDIlkv 670  Cryptospori...
16_pfamImport    73 YRLe-----EEtPLIIDML-------EligeLSETDEnykafsif---------rdpttreeAEFLLGEHVELLYDY--- 128 
161_pfamImport   73 FKL------AEsAPVAELF-------------LLDNEest------------eeEAQK----CVEFLVDNREMLNDY--- 114 
4E4W_A          147 YSIELvnd--glD-NDlksVKLKSLPLLLKG-Y--IPSLVKLPFFIYRLGKEvDWE--DEQECLDGILREIA-LLYIpdm 217  Saccharomyc...
120_pfamImport  132 FSIEI-------T-HD---GHLLALPFGLNSsW--PPSPRVVPLFIWRLAAEvPYRe-DEVACFTAIARHIAdTLYG--- 194 
Q57TS9          755 FAVEI-------S-AD---GHLIALPLSMGTsW--PPPLRAVPLFIWRLAAEvPYNa-GEIECFTAIARHIAeTLYGvql 820  Trypanosoma...
109_pfamImport  125 VGIVI---------KD---QKLLAFPNLFNL-FenDNNFKDISYILLRIITKvNFS--EILQSGMGLANELS-FYFAwql 188 
Q4Y1V0          157 FSLVI---------ED---GHIVTFPSCCGE-Y--FPGQEFLPLLFLRLASQiDYE--NEINCINGICYLLA-NFYS--- 215  Plasmodium ...
Q8IIJ0          838 FSIII---------ED---GCIVTFPACCGE-Y--FPGQEFLPFLFLRLATQiDYS--KEINCINGICYLLA-NFYS--- 896  Plasmodium ...
21_pfamImport   128 FSIII---------ED---GCVCTFPACCGE-Y--FPGQEFLPLLFLRLATQvDYE--NELNCINGICYLIA-NFYS--- 186 
Q5CRJ3          671 LGIDF-------DsSN---NSFSTLPLFFGN-F--VPNIDFLPELFEHVIFA-CWNfhIAHACKQKLLNTGSaQILN--- 733  Cryptospori...
16_pfamImport   129 FAIKMewmclegEkRR---LHITEIPSLVHH-Y--VPQLEKLPFLVASLILDvEYD--DEQKCFQSICRAIA-ELFTlhs 199 
161_pfamImport  115 FCLRIs--------PE---GSLETLPSLIDG-Y--VPQLEGLPALISTLVYDvDWE--QEKTCFEGICWALA-RFFCihe 177 
4E4W_A          218 vpKV-----------------------------------------------DTsdaslsede----kaqfinrkeHISSL 246  Saccharomyc...
120_pfamImport  195 --LRlhda----------------------------------------wvePRvspspgveppgdgrgeeggsvpSLFDA 232 
Q57TS9          821 hsswlpnv--------------------------------------------------------ikdgirqddvpPFCDA 844  Trypanosoma...
109_pfamImport  189 eksfknql--------------------------------------------------------qrqhfqetqkqKWDDF 212 
Q4Y1V0          216 --KItltsdtewtyqdelkmikereigmlqnlkkgnnskndgqtegnaqndNInfdsilgdetvidvnkhlpvskNINLV 293  Plasmodium ...
Q8IIJ0          897 --KItllndkewtyqddllmiqekeke-iqmllnksnkhinnsnhhnqhydETnldyilgdesvvdinkhlsvsrNINLV 973  Plasmodium ...
21_pfamImport   187 --KVtllddkewtfqnellmlkekeiq--mlqgqattdgsgeasplanddqTYhfenilgdetvidvnrhlaaskNINLV 262 
Q5CRJ3          734 --P-------------------------------------------------HfneennclsdkisedyiiklyeLFIEL 762  Cryptospori...
16_pfamImport   200 pfitae------------------------------------------------------------kkvsafcgtHWKPL 219 
161_pfamImport  178 kfcegdl-----------------------------------------------------------ssdvvadslPWRRI 198 
4E4W_A          247 LE-------------HVLFPCIk---RRFLAPRHILK--DVVEIANLPDLYKVFERC 285  Saccharomyces cerevisiae S288c
120_pfamImport  233 IR-------------FALLPCAts-sKLFVPPADALIdgTIQTVVSVEELYKVFERC 275 
Q57TS9          845 IR-------------FGLLPCAtn-sTFFVPPCDALVdgTVQAVVSVDELYKVFERC 887  Trypanosoma brucei
109_pfamImport  213 FE-------------QKMLPMIk---KKLSLPKLDISe-FTVKLFKQEDAYKIFERC 252 
Q4Y1V0          294 FE-------------KYFFPMIql-nNSMKIPNIFSTngYIIELTSLNQLYKIFERC 336  Plasmodium chabaudi
Q8IIJ0          974 FE-------------KYFFPMIql-nNIMKIPTTFSNngYIIELTSLNQLYKIFERC 1016 Plasmodium falciparum 3D7
21_pfamImport   263 FE-------------KYFFPMIql-nTIMRVPRTFSTngYIIELTSLNQLYKIFERC 305 
Q5CRJ3          763 IEilvdyylfgiednELLFQAIrnnnNLILVEDQISQn--IIELSSLEKLYRVFERC 817  Cryptosporidium parvum
16_pfamImport   220 IK-------------QVLMPLVk---RKFIPPEHFKSadIFVQLADSHDLYKVFERC 260 
161_pfamImport  199 FS-------------DLLYPALk---NNFIPPQSLCSh--IRRLADLQDLYKVFERC 237 
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