Conserved Protein Domain Family
CLZ
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pfam16526: CLZ (this model, PSSM-Id:318679 is obsolete and has been replaced by 465160)
C-terminal leucine zipper domain of cyclic nucleotide-gated channels
The CLZ domain is the C-terminal leucine-zipper domain of of cyclic nucleotide-gated channel proteins. The CLZ domains form homotypic trimers in solution thus constraining the channel of the CNGs to contain three cyclic nucleotide-gated subunits, CNGA. The CLZ domains formed homotypic parallel 3-helix coiled-coil domains, consistent with their proposed role in regulating subunit assembly.
Links
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Statistics
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PSSM-Id: 318679
Aligned: 55 rows
Threshold Bit Score: 52.5364
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0GFG2       574 LEEKGRQILIKEGLLEE--V-EADGIGVEDIEKRVERMEDTIEILQTRFARLLAQYTATQQHLKQRLTTLECR 643 zebrafish
XP_008190761 620 LTERGCQLLRKDGLLDEdvF-KKAKETQDSVLDSIKKLENTVEILQTRLARLLAEFSASQAKLKQRLTRLEls 691 red flour beetle
GAA53384     489 LMKRGEEILRKDNLIDEe-VlRKAKEQKESLDEYVRRLEGTVNNLSTRLARLIGEYGASQAKLKRRITQLEEY 560 Clonorchis sinensis
CCD78058     543 LMQRGQDILRKDNLLDEdiL-RKAQEQQESIEQCVQRIDNTMNQLTTRLARLIGEFGASQAKLKRRLTRLEQE 614 Schistosoma mansoni
XP_017044746 718 LTQRGCQLLRKDGLLDEqiF-ADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLEMN 789 Drosophila ficusphila
KFB42950     526 LTERGCQLLRKDGLLDEavF-ANAQQTQDSLESGVARLEQTVENLNLRLARLLAEYSASQAKLKQRISKLEDR 597 Anopheles sinensis
KRX62694     640 LINKGKEILRKDNLLDEt-V----EDEQEQADRLADSFQARLQALKDRYETVIGRYEEMHRRMNRRIAFLESK 707 Trichinella sp. T9
NP_001027710  10 ML---K--LDKENAIDRa---EQAETDKKSAEDKATGLEEELQGLQKRLKATEDELDTSQEKLRTAIENLENA 74  vase tunicate
XP_012548956 532 LTERGCQLLRKDGLLDEalF-ESAQTTQQSIEETVHKLETTVEMLNNRLQGLLADVGEEQAEMKQRMNNIEVR 603 domestic silkworm
EHJ65540     606 LTERGCQLLRKDGLLDEtvF-QNAQTTQQSLEETVHQLEATVEMLHNRLQGLLSNFGEQQAKLKQRLNKVELR 677 monarch butterfly
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