Conserved Protein Domain Family
UPAR_LY6_2
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pfam16975: UPAR_LY6_2 (this model, PSSM-Id:319044 is obsolete and has been replaced by 435685)
Ly6/PLAUR domain-containing protein 6, Lypd6
UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.
Links
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Statistics
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PSSM-Id: 319044
Aligned: 21 rows
Threshold Bit Score: 159.072
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003225521  41 TPYPGGFKCFTCEQAVDNYECNQWAPDIYCPRVTRYCYTQHTLEANGKSVSVTKRCVPLEDCLATGCIDLQHKGLRVCTS 120 green anole
XP_006003862  41 TPYPGGFKCFTCENASDNYECNRWAPDVYCPRGTKYCYTQHRMDSNGMSISVTKQCMSLEGCMSTGCSETKLEGHKVCTS 120 coelacanth
XP_003440959  41 TPYPGGFKCFTCQDAVDNYDCNRWAPDVYCPKDTKYCSTLHMMDRSGESVSVTKRCATMEECLFTGCADVADTGYQVCSS 120 Nile tilapia
NP_001181696  41 TPYPGGFKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTS 120 Rhesus monkey
OCA23859      41 TPYPGGFKCFTCEKAADNYDCNRWAPDIFCPRETRYCYTQHIMNATGESVSVTKRCAALEHCLNSGCRDSINKDQKVCTS 120 tropical clawed...
Q66IA6        41 TPYPGGFKCFTCEDAPDNYECNRWAPDLYCPRESRYCYTHHKMSWDGNTVSVTKRCVPLEDCLQTGCSDIDHEGNRVCTA 120 zebrafish
XP_013053574  41 TPFPHGFKCFTCEKAADNYECNRWAPDVYCPRGTRYCFSQHMMKVTGESVSVTKRCVPLEDCLSTGCTYVKHEEYKVCTS 120 Anser cygnoides...
XP_004066739  39 TPHPGGFKCFTCEDAPDNYQCNRWAPDVFCPKGTKYCYTLHMMDDNGSSVSVTKRCATLENCQLTGCVNVTRTGYQMCTS 118 Japanese medaka
XP_007669503  41 TPYPGGFKCFTCEKAADNYDCNRWAPDVYCPREARYCYTQHTMAASGNSVSVTKRCVALEDCLSTGCVDLEVEGHK---- 116 platypus
XP_023184926  42 TPHPGGFKCFTCQDAADNYNCNRWAPDvycpkdTSYCYTLHMMDNHGDSVSVTKRCATLEHCRFAGCVNITHNGFQVCTS 121 southern platyfish

XP_003225521 121 CCEGNICNLPLPRNASDAI---FATTTP 145 green anole
XP_006003862 121 CCEGNICNLPLPWNASDAI---FATISP 145 coelacanth
XP_003440959 121 CCEGNICNVLVPRNDSSAI---FSSISP 145 Nile tilapia
NP_001181696 121 CCEGNICNLPLPRNETDAT---FATTSP 145 Rhesus monkey
OCA23859     121 CCEGNICNLPLPRNETDAI---FATTSP 145 tropical clawed frog
Q66IA6       121 CCEGNICNLPLPRNETDAI---FSTTSP 145 zebrafish
XP_013053574 121 CCEGSICNLPLPRNTTDAV---FTTLSP 145 Anser cygnoides domesticus
XP_004066739 119 CCEGNICNIMVPRNDSSAI---FSSTSP 143 Japanese medaka
XP_007669503 117 ---GNICNC----DASQRVgrhFATTSP 137 platypus
XP_023184926 122 CCHGNICNVLVPRNDSGAV---FSSAGP 146 southern platyfish
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