1F58,4I2X,2WNG,1ADQ,1B2W,1FYT,1HDM,1HDM,1HXM,1IGA,1O0V,1O0V,1O0V,1O0V,1PY4,1S9V,1S9V,1XZ0,1ZVO,1ZVO,1OW0,1IGA,2WNG,1ZVO,1DGI


Conserved Protein Domain Family
IgC

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cd00098: IgC 
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Immunoglobulin Constant (IgC) domain
Members of the IgC family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.
Statistics
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PSSM-Id: 319274
View PSSM: cd00098
Aligned: 75 rows
Threshold Bit Score: 58.9911
Threshold Setting Gi: 6980440
Created: 20-Feb-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:Dimerization of IgC1 domains from different chains is common, but not found in all members
  • Structure:1OW0: human IgA Fc dimerization interface, defined at 3.5 A.
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  • Structure:1O0V; human IgE Fc dimerization interface, defined at 3.5 A.
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  • Comment:Human IgE Fc is a disulfide-linked dimer of 3 domains: C epsilon 2, C epsilon 3, and C epsilon 4.
  • Structure:1ADQ; human IgM Fab heavy and light chain IgC interface, defined at 3.5 A.
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  • Citation:PMID 9145108
  • Structure:1FYT; human T-cell receptor alpha/beta chain IgC1 interface, defined at 4 A.
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  • Structure:1S9V; human class II major histocompatibility antigen (HLA-DQ2), alpha/beta chain interface, based on 3.5 A distance.
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  • Structure:1S9V; human class II major histocompatibility antigen (HLA-DQ2) alpha/beta chain IgC1 interface, defined at 3.5 A.
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  • Structure:1HDM; human non-classical class II major histocompatibility antigen (HLA-DM), alpha/beta chain interface, defined at 3.5 A.
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  • Structure:1HDM; human non-classical class II major histocompatibility antigen (HLA-DM), alpha/beta chain IgC1 interface, defined at 3.5 A.
    View structure with Cn3D
  • Citation:PMID 9768757

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      ####              # # # #                                      #### # ##       
1F58_L    119 VSIFPpsseq---ltsggASVVCFLNnfypkDINVKWKidgserqngvln---swtdqdskdstYSMSSTLTLtkdeyer 192 house mouse
1HDM_A    100 AEVFTlkple----fgkpNTLVCFVSnlfppMLTVNWHdhsvpvegfgp-----tfvsavdglsFQAFSYLNFtpe---p 167 human
1HDM_B     93 VQVAKttpfn----trepVMLACYVWgfypaEVTITWRkngklvmhssa----hktaqpngdwtYQTLSHLALtps---y 161 Homo sapiens
1PY4_A      8 IQVYSrhpae----ngksNFLNCYVSgfypsDIEVDLLkngeriekveh-----sdlsfskdwsFYLLYYTEFtpt---e 75  human
1S9V_A     91 VTVFSkspvt----lgqpNILICLVDnifppVVNITWLsnghsvtegvs----etsflsksdhsFFKISYLTLlps---a 159 human
1S9V_B     99 VTISPsrtea----lnhhNLLVCSVTdfypaQIKVRWFrndqeetagvv----stplirngdwtFQILVMLEMtpq---r 167 human
1XZ0_A    189 AWLSHgpsp-----gpghLQLVCHVSgfypkPVWVMWMrgeqeqqgtqr-----gdilpsadgtWYLRATLEVaag---e 255 human
1OW0_A    109 VHLLPppseel--alnelVTLTCLARgfspkDVLVRWLqgsqelprekyltwasrqepsqgtttFAVTSILRVaaedwkk 186 human
AAL79934  322 VFATVtlsepsatllqgtNELVCLVFgfspaSINITWFldesvplldyn----tsephesqngkFSVQSHLRPpkgnwlp 397 Atlantic halibut
AAV28081  418 VTPSAptatl----lqgpSELACLVLgfsssDINITWLlddvtelwnnn----tsttyrapggkFGIRSHLSLahqdwtp 489 brown trout
Feature 1                         ###
1F58_L    193 hnSYTCEATHktst-spiVKSFN 214 house mouse
1HDM_A    168 sdIFSCIVTHepdr-ytaIAYWV 189 human
1HDM_B    162 gdTYTCVVEHigap-epiLRDWT 183 Homo sapiens
1PY4_A     76 kdEYACRVNHvtls-qpkIVKWD 97  human
1S9V_A    160 eeSYDCKVEHwgld-kplLKHWE 181 human
1S9V_B    168 gdVYTCHVEHpslq-spiTVEWR 189 human
1XZ0_A    256 aaDLSCRVKHsslegqdiVLYWV 278 human
1OW0_A    187 gdTFSCMVGHealplaftQKTID 209 human
AAL79934  398 gaIVTCRVSHan-----tTLSLN 415 Atlantic halibut
AAV28081  490 gaVYTCRVTHttq---nlALNIS 509 brown trout

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