1FYT,1HXM,1NFD,1KB5,1DQT,1RHH,2ADG,2ATP,2OTU,2UV3,3KHQ,1HXM,1NFD,1NFD,1RHH,1SQ2,1VES,2COQ


Conserved Protein Domain Family
IgV

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cd00099: IgV 
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Immunoglobulin variable domain (IgV)
IgV: Immunoglobulin variable domain (IgV). Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.
Statistics
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PSSM-Id: 319275
View PSSM: cd00099
Aligned: 22 rows
Threshold Bit Score: 89.3792
Threshold Setting Gi: 11514259
Created: 1-Nov-2000
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1NFD_A, human T cell receptor alpha/beta interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Structure:1RHH_B; human monoclonal antibody Fab X5 heterodimer, showing light and heavy chain interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Structure:2ADG_A, mouse monoclonal anti-Cd4 antibody Q425, Fab light and heavy chain interface, contacts based on 3.5 A
    View structure with Cn3D
  • Structure:1HXM_B, human T cell receptor gamma/delta interface, contacts based on 3.5 A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                             # # # #        # #                                      
1FYT_D     10 VSVSEGALVLLRCNYsss---vpPYLFWYVQypn---qgLQLLlkytsaat-----lvkgingFEAEFKksetSFHLTKP 78  human
1HXM_B     11 STKTLSKTARLECVVsgit-isaTSVYWYRErpg---evIQFLvsisydgtvr-kesgipsgkFEVDRIpetsTSTLTIH 85  human
1NFD_A     10 VTVTEGLPVKLNCTYqtt--yltIAFFWYVQyln---eaPQVLlksstdn------krtehqgFHATLHksssSFHLQKS 78  Mus musculus
1KB5_B     11 RLVPRGQAVNLRCILkns---qyPWMSWYQQdlq---kqLQWLftlrspgdk--evkslpgadYLATRVtd-tELRLQVA 81  house mouse
1DQT_A      9 VLASSHGVASFPCEYspshntdeVRVTVLRQtn----dqMTEVcattftekn--tvgfldypfCSGTFNe--sRVNLTIQ 80  house mouse
2ADG_A     11 LSVAIGEKVTIRCITstd---idDDMNWYQQkpg---epPKFFisegntl------rpgvpsrFSSSGYg--tDFVFTIE 76  house mouse
2ATP_B      8 LLVQTNHTAKMSCEVksi--sklTSIYWLRErqdpkdkyFEFLaswssskgvlygesvdkkrnIILESSds-rRPFLSIM 84  house mouse
2OTU_A     11 ASFSLGASAKLTCTLssq--hstYTIEWYQQqpl---kpPKYVmelkkdgsh--stgdgipdrFSGSSSg--aDRYLSIS 81  house mouse
1NFD_B     11 IIKEKGGRSVLTCIPis----ghSNVVWYQQtlg---keLKFLiqhyekver---dkgflpsrFSVQQFdd-yHSEMNMS 79  Mus musculus
1NFD_E      9 ASVTVGETVKITCSGdql---pkNFAYWFQQksd---knILLLiymdnkr------psgiperFSGSTSg--tTATLTIS 74  Mus musculus
Feature 1             # # #               ###      
1FYT_D     79 sahmsdaAEYFCAVSespfg---neklTFGTGTRLTI 112 human
1HXM_B     86 nvekqdiATYYCALWeaqqel-gkkikVFGPGTKLII 121 human
1NFD_A     79 saqlsdsALYYCALSeggn-----ykyVFGAGTRLKV 110 Mus musculus
1KB5_B     82 nms--qgRTLYCTCSaapdwgasaetlYFGSGTRLTV 116 house mouse
1DQT_A     81 glravdtGLYLCKVElmypp---pyfvGMGNGTQIYV 114 house mouse
2ADG_A     77 nmlsedvADYYCLQSdtl-------plTFGSGTKLEI 106 house mouse
2ATP_B     85 nvkpedsDFYFCATVgsp-------kmVFGTGTKLTV 114 house mouse
2OTU_A     82 niqpedeAIYICGVGdtike---qfvyVFGGGTKVTV 115 house mouse
1NFD_B     80 aleledsAMYFCASSlrwg-----deqYFGPGTRLTV 111 Mus musculus
1NFD_E     75 gaqpedeAAYYCLSSygdn-----ndlVFGSGTQLTV 106 Mus musculus

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