Conserved Protein Domain Family
Ig4_L1-NrCAM_like

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cd04978: Ig4_L1-NrCAM_like 
Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
Ig4_L1-NrCAM_like: fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related). These proteins belong to the L1 subfamily of cell adhesion molecules (CAMs) and are comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. These molecules are primarily expressed in the nervous system. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth.
Statistics
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PSSM-Id: 319284
View PSSM: cd04978
Aligned: 7 rows
Threshold Bit Score: 106.772
Threshold Setting Gi: 17137624
Created: 22-Feb-2007
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAH72835   364 GEDGSLICRasGNPTPSITWLINGVSielaptd--asrrvdgDTIIFskvqd-gataVYQCNVSNk-yGYLLANAFVNVL 439  African clawed frog
1171701    341 GETARLDCEvgGKPRPQIQWSINGVPieaagae---rrwlrgGALVLpelrp-ndsaVLQCEARNr-hGPLLANAFLHVV 415  chicken
462740     351 GEDGTLICRanGNPKPSISWLTNGVPiaiaped--psrkvdgDTIIFsavqe-rssaVYQCNASNe-yGYLLANAFVNVL 426  chicken
AAC47654   349 EETAVFKCGveGIPRPTVEWMLNKRPledlppnprmrmnderTVLTFsnvss-kdiqVIQCNASNv-hGYILANAYLNVF 426  medicinal leech
ABQ57414   344 ESTGELECLagGQPTPIITWSMNGKFlhelaedsrrvlldhgRILRVrnlnhdldtgVYQCNASNp-lGYVFANAFVHVR 422  nematode
NP_477404  147 GAIFEVVCEaqGVPQPVITWRLNGNViqpqs------ntgnrQSLILeiksr-nqagLIECVASNgvgEPAVANVYLHVL 219  fruit fly
O00533     345 GSNGILLCEaeGEPQPTIKWRVNGSPvdnhpfa---gdvvfpREISFtnlqp-nhtaVYQCEASNv-hGTILANANIDVV 419  human
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