1RHH,1ZV5,2IG2,2ZJS,1ZVO


Conserved Protein Domain Family
IgV_H

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cd04981: IgV_H 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig) heavy chain (H), variable (V) domain
IgV_H: Immunoglobulin (Ig) heavy chain (H), variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determine the type of immunoglobulin: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.
Statistics
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PSSM-Id: 319286
View PSSM: cd04981
Aligned: 17 rows
Threshold Bit Score: 166.744
Threshold Setting Gi: 58201853
Created: 23-Apr-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1RHH_B; human monoclonal antibody X5 IgV light and heavy chain heterodimer interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Structure:1RHH_B; human monoclonal antibody X5 Fab light and heavy chain heterodimer interface (including constant domains of Fab), contacts based on 3.5 A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                           #   #   #                                 
1RHH_B      5 LEQSg---AEVKKPGSSVQVSCKASGgtfsMYGFNWVRQAPGHGLEWMGGIipifgtsnyaqkfrgRVTFTADQATSTAY 81  Homo sapiens
1ZV5_A      4 LVESg---GGSVQAGESLRLSCAASGvtykNYCIGWFRQAPGKDREGVVFInsdggityyadsvkgRFTISQDNAKNTVY 80  Camelus dromedarius
2IG2_H      4 LVQSg---GGVVQPGRSLRLSCSSSGfifsSYAMYWVRQAPGKGLEWVAIIwddgsdqhyadsvkgRFTISRNDSKNTLF 80  Homo sapiens
2ZJS_H      4 LQQSg---AELMKPGASVKISCKATGytfsSYWIAWVKQRPGHGLEWIGEIlpgsgstnynekfkgKATFTADTSSNTAY 80  house mouse
CAM73236   24 LVESe---AVVIKPDQSHKLTCTASGfnfgGSWMAWIRQAAGKGPEWVATLsngnsyiyysdkvkgRFTISRDDNKNQLY 100 zebrafish
AAX78210   21 ALESipstSVLKKPGEALXLSCRGTGftfsQHGMHWIRQPAGKALEWIGAIwydasktvyassvqgRIEITRDNSNSMVY 100 orange-spotted gro...
ABW36934    4 LVQSg---PELKKPGETVKISCKASGytftNYGMNWVKQAPGKGLKWMGWIntntgestyaeefkgRFAFSLETSASTAY 80  house mouse
ABF19894    4 LQQPg---SELVRPGASVKLSCKASGytftSYWIHWVKQRPGQGLEWIGNIdpggggsdfnekftnKATLTVDTSSSTAY 80  house mouse
AAW66977   23 LSQPa---SMTVLPGQPLTISCKVSYsv-tNTWTAWIRKPAGKGLEWIGNVysgdtry--kdslknKFSLSVDSSSNTVF 96  rainbow trout
S17597      4 LEESg---GGVVQPGRSLRLSCEASGlrfsIYGMFWVRQAPGKGLEWLALIwndgsrkhyadsvkgRFTVSRDNSKNTLY 80  human
Feature 1                   #                         ##        
1RHH_B     82 MELTNLRSDDTAVYYCARDfgpdwedgdsydgsgrgfFDFWGQGTLVTVS 131 Homo sapiens
1ZV5_A     81 LQMNSLKPEDTASYYCAAGyrny----------gqcaTRYWGQGTQVTVS 120 Camelus dromedarius
2IG2_H     81 LQMDSLRPEDTGVYFCARDgghgfcs-----sascfgPDYWGQGTPVTVS 125 Homo sapiens
2ZJS_H     81 MQLSSLTSEDSAVYYCARSpyy------------ygnWDYWGQGTTLTVS 118 house mouse
CAM73236  101 LQMNSLKTEDTAVYYCARGmew-------------ryFDYWGKGTKVTVS 137 zebrafish
AAX78210  101 LRLSNLKPEDSAVYYCARHggs-------------eyFDYWGKGTQVTVT 137 orange-spotted grouper
ABW36934   81 LQINNLKNEDTATYFCARElrp------------yhvMDYWGQGASVTFS 118 house mouse
ABF19894   81 MQLSSLTSEDSAVYYCTTG------------------FAYWGQGTLVTVS 112 house mouse
AAW66977   97 LKGQNLQTEDSAVYYCAYGngg-------------daFDYWGKGTMVTVS 133 rainbow trout
S17597     81 LQMNSLRADDTAVYFCGSGttafsga-----apdnyhIHVWGKGTTVTVS 125 human

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