2ATP,3B9K,3DMM


Conserved Protein Domain Family
IgV_CD8_beta
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cd07700: IgV_CD8_beta (this model, PSSM-Id:319326 is obsolete and has been replaced by 409497)
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Immunoglobulin (Ig) like domain of CD8 beta chain
IgV_CD8_beta: immunoglobulin (Ig)-like domain in CD8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion and a short intracellular domain.
Links
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Statistics
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PSSM-Id: 319326
Aligned: 15 rows
Threshold Bit Score: 160.685
Created: 25-Oct-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:2ATP_B; mouse CD8 alpha forms a heterodimer with CD8 beta, defined using 3.5 A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                #   #         # #                                       
2ATP_B         8 LLVQTNHTAKMSCEVksisklTSIYWLRErqdp-kdkyFEFLASWSSs-kGVLYGEsvdkkrNIILESSdsrRPFLSIMn 85  house mouse
P10966        29 IKVQTNKMVMLSCEAkislsnMRIYWLRQrqapssdshHEFLALWDSa-kGTIHGEev--eqEKIAVFRdasRFILNLTs 105 human
NP_998927     29 VMAQTNQTVKLSCEArtfptnTRIYWLRLrqalsanshYEFLALWIPn-gNPVYGKet---eKQLTVLQdssRYLLQLRh 104 pig
XP_008834948  26 MMVLTNQMVKLSCEMkiytksTPIYWLRQlqgptkdshFEFLVSWNPt-kGIVYGEgmtaekLTVSSDTa--QPILNLTs 102 Upper Galilee m...
AAW63043      29 TTAQTNQTVTLSCEAktsptnSRIYWLRQrlapsanshFEFLAFWDLt-rGTVYGEevgqerLTVLRDSs--RYTLSLQs 105 bottlenosed dol...
XP_006991068  29 LTLLTNRSAKVFCEAkslpktTLIHWLRQrrgpakerrFEFLASWNPskgTSVYGEgvkkedMIMSSDIs--RYILELKs 106 prairie deer mouse
XP_001497922  29 QMVQTNQMVVLTCEArttypnKRIYWLRQrqapsadshQEFLAAWDSi-kGIVYGEkl--dqEKLTLSQdasRSTLHLAh 105 horse
ERE66372      29 LTVLTNQVAKVSCEAktlpktTLIYWLRQrrgptkdkhFEFLASWNPskgVATPGEgv--kkESINVFSditRYILNLTs 106 Chinese hamster
NP_001009867  29 VMVQTNGMVIMSCEAktsptsTRIYWLRHrqapspdshYECLAYWDPi-kGIVYGQevepekLTVFPDAt--RSILNLTs 105 domestic cat
EHA99116      29 LMVQTNQKVTMTCETktslsnKRIYWLRQrqahskdshHEFLVSEDFs-kNITYGRgvtqrtLALLRSTt--RFTLSLMh 105 naked mole-rat

Feature 1                     #      ##       
2ATP_B        86 vkpedsDFYFCATVgspkmVFGTGTKLTV 114 house mouse
P10966       106 vkpedsGIYFCMIVgspelTFGKGTQLSV 134 human
NP_998927    105 vkpadsGNYFCMAVgnpelTFGKGTRLSV 133 pig
XP_008834948 103 vkpedsGIYFCMIVgspelIFGKGIKLIV 131 Upper Galilee mountains blind mole rat
AAW63043     106 vkpsdsGVYFCMTVgnpdlTFGKGTQLSV 134 bottlenosed dolphin
XP_006991068 107 vkledsGTYFCMMIgspnlIFGIGTELNV 135 prairie deer mouse
XP_001497922 106 vkpedsGVYFCMIIgtpelTFGTGTRLSV 134 horse
ERE66372     107 vkledsGTYFCMMVgspqlIFGSGTELSV 135 Chinese hamster
NP_001009867 106 vkpadsGIYFCMTVgspelTFGKGTRLSV 134 domestic cat
EHA99116     106 vkpedsGVYFCMTMgapelIFGTGTSLSV 134 naked mole-rat

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