cd16091: Ig_HHLA2 (this model, PSSM-Id:319340 is obsolete and has been replaced by 409512)
Immunoglobulin (Ig) domain in HERV-H LTR-associating 2
HERV-H LTR-associating 2 (HHLA2) is a protein ligand found on the surface of monocytes which is believed to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.
Jiyao W et al.(2023). "The conserved domain database in 2023.",