2PKD,2IF7


Conserved Protein Domain Family
Ig_SLAM-CD84_like_N

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cd16842: Ig_SLAM-CD84_like_N (this model, PSSM-Id:319347 is obsolete and has been replaced by 409517)
Click on image for an interactive view with Cn3D
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family
Ig_SLAM-CD84_like_N: The N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar domains. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.
Statistics
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PSSM-Id: 319347
Aligned: 14 rows
Threshold Bit Score: 103.563
Created: 17-Aug-2016
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1IF7_a, human NTB-A receptor dimer interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Structure:2PKD_A; human CD84 dimer interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:of the two dimerization modes suggested by the 2PKD crystal structure, the head to tail dimer is believed to be the physiologically relevant species.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                            # #                                                         
2PKD_A        11 GILGESVTFPVNiqeprqvKIIAWTs---kTSVAYVTpgds--etapVVTVThrn-------yyeRIHALGp--nYNLVI 76  human
2IF7_A        10 GILGESVTLPLEfpagekvNFITWLfn--eTSLAFIVphet---kspEIHVTnpk-------qgkRLNFTQs---YSLQL 74  human
AAI49437      49 GTLGGSVTLPLQlqdgqqvESISWVsrsvpGAIATVTlvea--ggpdTFHQEesr-------ywgRLSVVGp--dRSLQI 117 cattle
XP_001379334  36 GVLGESAILPLTipkekqiTYILWTs---kRSLAIIEmgke--gnanKTTIIdph-------ykeRVNFLKqsynYAMQI 103 gray short-tail...
XP_001379348  38 GILGESAILPADipdknkiDNINWAs---rTPVAVVTpeg----tavNIITThqn-------ykgRLNVSSk--tYDLQI 101 gray short-tail...
XP_001518697  30 GTIGGMVTFPLDipagrrvTNIDWRa---kQTIAKVSpgeagnlpklNFVLPqy---------keRLSVSTd---YSLTI 94  platypus
NP_001069386 257 GVLGESITLSLAlldsqhiDNVVWIf---nTSIISKEwr-------eEATANqliefk--dpdqnTVWVSSq--dYSLKI 322 cattle
NP_001069386  57 AIVGGSVILSLNisvdaeiEQITWSg---pKDALVLAfp-------sGEILFldks------ykgRINIPKn---NSLSI 117 cattle
XP_001379526  38 LVLGESVSLPVNieegeeiEKIIWSf---hSTLAVIQqea-----mkEPSISivpdp----rynvIVNISDh--tYSLHI 103 gray short-tail...
XP_001380120 635 GIVGGFILFPLNvsleteiQEIEWRf---kSEQLQLLs--------lKPGASsflwynpldrykeRLEILEd---SSLII 700 gray short-tail...
Feature 1                   # # #                   
2PKD_A        77 SDLRMEDAGDYKADINtqa--dpyTTTKRYNLQIY 109 human
2IF7_A        75 SNLKMEDTGSYRAQIStk----tsAKLSSYTLRIL 105 human
AAI49437     118 SHLNWADAGSYRAHINlrs--srlTHTREYSLHVY 150 cattle
XP_001379334 104 NHLKMEDAGSYQAEITian--itePMKKMFTLHIH 136 gray short-tailed opossum
XP_001379348 102 NHLKMEDAGFYRADINlktsststTITKNYTLQIY 136 gray short-tailed opossum
XP_001518697  95 SNLRPEDAGTYRVRINtvnatsnsFTNMEFSLRVY 129 platypus
NP_001069386 323 VQLKMEHAGLYQAYLCsna---rvASVKHINLRIY 354 cattle
NP_001069386 118 NKLTLKDAGSYKARINqkg---seDFNERFILYIY 149 cattle
XP_001379526 104 SNLSKEDEGTYRAEMNfeg--fpgTITQKFILRVY 136 gray short-tailed opossum
XP_001380120 701 RNLTPKDSGLYEARVIfns---gvFIIQTFVLSVY 732 gray short-tailed opossum

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