5KHD


Conserved Protein Domain Family
BldD_C_like

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cd16837: BldD_C_like 
Click on image for an interactive view with Cn3D
C-terminal domain of BldD and similar transcription factors
The Streptomyces transcription factor BldD dimerizes via an unusual mechanism that inolves a tetrameric c-di-GMP assembly. BdlD is involved in controlling multicellular differentiation in sporulating actinomycetes.
Statistics
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PSSM-Id: 319351
Aligned: 36 rows
Threshold Bit Score: 65.254
Created: 18-Aug-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
c-di-GMP
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1: c-di-GMP binding site [chemical binding site], 14 residue positions
Conserved feature residue pattern:x x x R x D x x x x x R x DClick to see conserved feature residue pattern help
Evidence:
  • Structure:5KHD: C-terminal domain of a DNA-binding protein from Streptomyces venezuelae binds tetrameric c-di-GMP, contacts at 4.0 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # #                       #   ### #  ###### #                          
5KHD_R         7 PPKLVLDLERLAHVpqEKAGPLQRYAATIQSqRGDYNGKVLSIRQDDLRTLAVIYDqSPSVLTEQLISWGVLD 79  Streptomyces venezuela...
KIE49779      95 GQKIVIDLTKLDQVegPESEMIERYLTIIQVkRQDFNGRVLTIRGDDLQALAAILGtDVDAAAPRLEELGLLY 167 marine actinobacterium...
AKL73755      84 NQGFTIDLTQLGDSedPEAAVLARYAATIQLqRQDFNGRLLTIRRDDMRVLAAVLGrRTEDLPTRLEQLGLRA 156 Actinobacteria bacteri...
WP_012230758  96 DSGAKINLARLEGLegSEADMLSRYLLMIQVqRQDFNGRVITIRRDDMRAIACILGmAEEHVPGRLAELGLRL 168 Candidatus Microthrix ...
WP_015798707 117 TEKCTIDLQRLRSLegPERELLERYLGMIQVqRQDFNGRVMTVRREDLRIIGALLGlSLEGMIEHIDRLGLRA 189 Acidimicrobium ferroox...
KGA06903      76 TRSIALDLVKLSAEqsEYSSTIQRFARGICDrRKDWNGQVLTVRVNDLQFLAMLLQqGEPELLAELEKLGLIK 148 actinobacterium acIB-A...
KGA03885      76 DRSLSLNLHKLSKIenSTAQSLRKFTKSIGDrRKDWNGQLLTIRANDLQFLALLLGiDESATLDYLAEAELLN 148 actinobacterium acIB-A...
KGA11060      76 ARSVSVNLNKLAESseTKSQILQRFTKSISNrRKDWNGQILTIRANDLQFLALQIEkNEADTLDWLIESELIH 148 actinobacterium acIB-A...
KRO50296      76 ARSISVNIAKLESTtdHQAQTLRKFTKSISNrRKDWNGQILTIRSNDLQFLALLIEkSEPDTLDWLIESQLIH 148 Actinobacteria bacteri...
KGA09414      76 ARSLTLDLVRISTGtdTNTAQIRRFTRLVSDrRKDWNGQLLTIRANDLQFLSLLLGlTDAATLDYLTEAELLT 148 actinobacterium acIB-A...

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