2HQV,2OVI,2PH0,4CDP,4CDP


Conserved Protein Domain Family
ChuX-like

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cd16827: ChuX-like 
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heme utilization protein ChuX and similar proteins
This family contains ChuX, a member of the conserved heme utilization operon from pathogenic E. coli, and similar proteins, which include ChuS, HutX, HuvX, HugX, and ShuX in proteobacteria, among others. It forms a dimer which displays a very similar fold and organization to the monomeric structure of other heme utilization proteins such as HemS, ChuS, HmuS, PhuS; these latter occurring as duplicated domains. They all bind heme via a key conserved histidine. The genes encoded within these heme utilization operons enable the effective uptake and utilization of heme as an iron source in pathogenic microorganisms to enable multiplication and survival within hosts they invade.
Statistics
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PSSM-Id: 319356
View PSSM: cd16827
Aligned: 7 rows
Threshold Bit Score: 162.18
Threshold Setting Gi: 505061070
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2HQV_A        43 AIAAKae--vaPAEILAIlpqgaAVSApa--drFDAIWNEXRGWGe-ILXIVQTgdIVLEVpghLPEGTEshGWFNIHGd 117 Agrobacterium f...
2OVI_A        18 LEVVAeqynttLLEVVRNlp--sSTVVpg--dkFDTVWDTVCEWGn-VTTLVHTadVILEFsgeLPSGFHrhGYFNLRGk 92  Escherichia col...
2PH0_A        17 LEDIAgkyntsLFAVVEAlptaqCTLAtg--drFDQVWDTIATWGe-VTLISHTadAILEFkseLPTGTHrhGYFNLRGk 93  Pectobacterium ...
4CDP_A        31 ARDIAglmnirEAELAFArvthdAWRMhg---dIREILAALESVGe-TKCICRNeyAVHEQvgtFTNQHLngHAGLILNp 106 Escherichia col...
4CDP_A       207 FFTLLkrhnltRQQAFNLvaddlACKVsn--saLAQILESAQQDGneIMVFVGNrgCVQIFtgvVEKVVPmkGWLNIFNp 284 Escherichia col...
WP_015248172  27 TMMAArkfgvtEKSVVDAlv-gqWPIVrlregvFRELLEALPALGt-MRVFVRSraAVIESvgtFGGFSDagPFFNVQTd 104 Singulisphaera ...
KXK13166      33 TLMLAhqlkiqEVEILRAlqgdtAFEFda--trWEEIIRDFEALGq-VTVIVSNgaTTVEVfgqFGKFFNkdGFLNIRTd 109 Chloroflexi bac...
2HQV_A       118 spIGGHIKKdncaAITFVDRGfh--grRSCSVWFXNaaGGAXFKIFVRRDenkellaGQLAKFEEL 181 Agrobacterium fabrum str. C58
2OVI_A        93 hgMSGHIKAenctHIALIERKfm--gmDTASILFFNkeGSAMLKIFLGRDdhrqllsEQVSAFHTL 156 Escherichia coli O157:H7
2PH0_A        94 ngLSGHIRAtscqHIAFIERKfx--gxDTASVVFFNanGAAXFKIFLGRDshrqllsAQVDAFRAL 157 Pectobacterium carotovorum
4CDP_A       107 raLDLRLFLnqwaSVFHIKENta--rgERQSIQFFDhqGDALLKVYATDNtd---maAWSELLARF 167 Escherichia coli O157:H7
4CDP_A       285 -tFTLHLLEesiaEAWVTRKPts--dgYVTSLELFAhdGTQIAQLYGQRTegeqeqaQWRKQIASL 347 Escherichia coli O157:H7
WP_015248172 105 -tLDMHILHeeiaDIFAVEKWghdtttATYSFQFFDhsGDAAFKAFLWESfpd-vpkETIEAFHTL 168 Singulisphaera acidiphila
KXK13166     110 -tLDMHIRGwelaSVFAFKKPshldkhESLSIQFYDrrGNAAFKVFFNFGgde-psaELVEKYNQF 173 Chloroflexi bacterium OLB14
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