Conserved Protein Domain Family

cd16449: RING-HC 
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HC subclass of RING (RING-HC) finger and its variants
RING finger is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc. It is defined by the "cross-brace" motif that chelates zinc atoms by eight amino acid residues, typically Cys or His, arranged in a characteristic spacing. Canonical RING motifs have been categorized into two major subclasses, RING-HC (C3HC4-type) and RING-H2 (C3H2C3-type), according to their Cys/His content. There are also many variants of RING fingers. Some have a different Cys/His pattern. Some lack a single Cys or His residue at typical Zn ligand positions, especially, the fourth or eighth zinc ligand is prevalently exchanged for an Asp, which can chelate Zn in a RING finger as well. This family corresponds to HC subclass of RING (RING-HC) finger proteins that are characterized by containing C3HC4-type canonical RING-HC fingers or noncanonical RING-HC finger variants, including C4C4-, C3HC3D-, C2H2C4-, and C3HC5-type modified RING-HC fingers. The canonical RING-HC finger has been defined as C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C. It binds two Zn ions in a unique "cross-brace" arrangement, which distinguishes it from tandem zinc fingers and other similar motifs. RING-HC finger can be found in a group of diverse proteins with a variety of cellular functions, including oncogenesis, development, viral replication, signal transduction, the cell cycle, and apoptosis. Many of them are ubiquitin-protein ligases (E3s) that serve as scaffolds for binding to ubiquitin-conjugating enzymes (E2s, also referred to as ubiquitin carrier proteins or UBCs) in close proximity to substrate proteins, which enables efficient transfer of ubiquitin from E2 to the substrates.
PSSM-Id: 319363
View PSSM: cd16449
Aligned: 200 rows
Threshold Bit Score: 25.8909
Threshold Setting Gi: 159164352
Created: 29-Oct-2015
Updated: 18-Aug-2016
Aligned Rows:
Zn binding siteRING-HC finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1      #  #              # #  #  #                #  #
1FBV_A     335 CkICAendk---dvkiEPCgHlMCtsCLTswqes-----egqgCPfC 373  human
1JM7_A      24 CpICLelik---epvsTKCdHiFCkfCMLkllnqk---kgpsqCPlC 64   human
P31244     537 CqLCNdeae---epieSKChHkFCrlCIKeyvesfmennnkltCPvC 580  Saccharomyces cerevisiae S288c
3914299    273 CtLCLeerr---hptaTPCgHlFCweCITawcs------skaeCPlC 310  human
Q09268      41 CsVCKneiid--ttslSDCcHeFCydCIVgwltk----gsgpfCPmC 81   Caenorhabditis elegans
O00463      45 CaFCHsvlh---nphqTGCgHrFCqhCILslrel----ntvpiCPvD 84   human
Q6Q0C0     131 CqLCCsvfk---dpviTTCgHtFCrrCALks----------ekCPvD 164  human
Q94AY3      20 CpLCDkllrd--attiSEClHtFCrkCIYekite----deiesCPvC 60   thale cress
Q86WT6      41 CpLCNdwfr---dplmLSCgHnFCeaCIQdfwrlq---aketfCPeC 81   human
Q9P1Y6     108 CpICLnafrdqavgtpENCaHyFCldCIVewsk------nansCPvD 148  human

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