2EP4


Conserved Protein Domain Family
RING-H2_RNF24_like

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cd16469: RING-H2_RNF24_like (this model, PSSM-Id:319383 is obsolete and has been replaced by 438132)
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
The family includes RNF24, RNF122, and similar proteins. RNF24 is an intrinsic membrane protein localized in the Golgi apparatus. It specifically interacts with the ankyrin-repeats domains (ARDs) of TRPC1, ?3, ?4, ?5, ?6, and ?7, and affects TRPC intracellular trafficking without affecting their activity. RNF122 is a RING finger protein associated with HEK 293T cell viability. It is localized to the endoplasmic reticulum (ER) and the Golgi apparatus, and overexpressed in anaplastic thyroid cancer cells. RNF122 functions as an E3 ubiquitin ligase that can ubiquitinate itself and undergoes degradation through its RING finger in a proteasome-dependent manner. Both RNF24 and RNF122 contain an N-terminal transmembrane domain and a C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319383
Aligned: 8 rows
Threshold Bit Score: 85.1971
Created: 2-May-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-H2 finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2EP4; Homo sapiens RNF24 binds two Zn2+ ions through its RING-H2 finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #  #              # #  #  #          #  #    
2EP4_A        16 ELCAVCLEDFKpRDELGICPCKHAFHRKCLIKWLEVRkvCPLCNMPV 62  human
XP_002129362  80 ETCPVCLEDFKkKEVLAICPCHHVFHKKCLCKWLELRptCPMCMSHI 126 Ciona intestinalis
EEN64318      51 KTCAVCLEDFKlMEEIGLCPCGHAFHRKCISKWLEIRntCPMCNSQV 97  Florida lancelet
Q9H9V4        91 QTCAVCLEDFKgKDELGVLPCQHAFHRKCLVKWLEVRcvCPMCNKPI 137 human
NP_001108199  88 QPCAVCLEEFKtRDELGVCPCSHTFHKKCLLKWLEIRsvCPMCNKPI 134 zebrafish
XP_013415876  59 DVCPVCLDEFKlKEKIALCLCRHAFHLKCLLQWLEQRnsCPMCNTQV 105 Lingula anatina
XP_013077189  61 DTCSVCLEEFKkGEKIAVCTCRHGFHSKCLEQWLEHKnnCPLCKAPV 107 Biomphalaria glabrata
EDO49300      82 DMCTICLEDFInKEEVNMCKCGHAYHNKCIMKWLEVRnsCPICQRGL 128 starlet sea anemone

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