Conserved Protein Domain Family
RING-H2_RNF32

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cd16471: RING-H2_RNF32 (this model, PSSM-Id:319385 is obsolete and has been replaced by 438134)
RING finger, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
RNF32 is mainly expressed in testis spermatogenesis, most likely in spermatocytes and/or in spermatids, suggesting a possible role in sperm formation. RNF32 contains two C3H2C3-type RING-H2 fingers separated by an IQ domain of unknown function. Although the biological function of RNF32 remains unclear, the protein with double RING-H2 fingers may act as a scaffold for binding several proteins that function in the same pathway.
Statistics
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PSSM-Id: 319385
Aligned: 5 rows
Threshold Bit Score: 67.2455
Created: 15-Apr-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF25 (5D1K) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #                         # #  #  #                                       # 
Q9H0A6       292 ECSICLAPLsaaggqrvgagrrsremALLSCSHVFHHACLLALEEFsvgdr----------------------ppfhaCP 349 human
Q9H0A6       126 PCPICKEEFelr------------pqVLLSCSHVFHKACLQAFEKFtnk---------------------------ktCP 166 human
XP_004365380 122 ACPVCLDEFdqd------------slARTECFHAFHTHCFESYLAArherrqelsrevinhwekvpellqvddvsqtqCP 189 Capsaspora owcz...
KHN75351     119 VCPICLNDFtsh-----------qpsVRTHCDHYIHQPCFATYIDYsrseiqrelsewp-------ddmkdkvdqalrCP 180 dog roundworm
XP_002769677 114 SCSICREPFrdt------------sqLILACTHSFHQRCFLSYLHYagse-------------------------tskCP 156 Perkinsus marin...
Feature 1         # 
Q9H0A6       350 LCR 352 human
Q9H0A6       167 LCR 169 human
XP_004365380 190 VCR 192 Capsaspora owczarzaki ATCC 30864
KHN75351     181 MCR 183 dog roundworm
XP_002769677 157 MCR 159 Perkinsus marinus ATCC 50983

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