2KIZ,5D0I,5D0K


Conserved Protein Domain Family
RING-H2_RNF111_like

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cd16474: RING-H2_RNF111_like (this model, PSSM-Id:319388 is obsolete and has been replaced by 438137)
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
The family includes RING finger proteins RNF111, RNF165, and similar proteins. RNF111, also known as Arkadia, is a nuclear E3 ubiquitin-protein ligase that targets intracellular effectors and modulators of transforming growth factor beta (TGF-beta)/Nodal-related signaling for polyubiquitination and proteasome-dependent degradation. It also interacts with the clathrin-adaptor 2 (AP2) complex and regulates endocytosis of certain cell surface receptors, leading to modulation of epidermal growth factor (EGF) and possibly other signaling pathways. The N-terminal half of RNF111 harbors three SUMO-interacting motifs (SIMs). It thus functions as a SUMO-targeted ubiquitin ligase (STUbL) that directly links nonproteolytic ubiquitylation and SUMOylation in the DNA damage response, as well as triggers degradation of signal-induced polysumoylated proteins, such as the promyelocytic leukemia protein (PML). RNF165, also known as Arkadia-like 2, or Arkadia2, or Ark2C, is an E3 ubiquitin ligase with homology to C-terminal half of RNF111. It is expressed specifically in the nervous system, and can serve to amplify neuronal responses to specific signals. It thus acts as a positive regulator of bone morphogenetic protein (BMP)-Smad signaling that is involved in motor neuron (MN) axon elongation. Both RNF165 and RNF111 contain a C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319388
Aligned: 18 rows
Threshold Bit Score: 74.6553
Created: 2-May-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-H2 finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #              # #  #  #           #  #   
2KIZ_A         15 EKCTICLSILeegEDVRRLPCMHLFHQVCVDQWLi-tNKKCPICRVD 60   human
ELU11354      257 ERCTICLSDFedsDEVRRLPCMHLFHIGCVDTWLs-sNRRCPICRVD 302  Capitella sp. I Grassle & Grassle, 1976
XP_003745478  110 VRCSICLTDYeveEEVRRLPCMHLFHAACIDQWFr-aDKRCPMCRVD 155  western predatory mite
BAM80912      290 PICTICLSQYepaEEIRKLPCGHHFHRACVDQWLlffDKSCPQCRSD 336  Cyanidioschyzon merolae strain 10D
ELU11856      213 LTCKICLSEFedkEEVRRLPCLHQYHTACIDEWLr-mKAQCPTCRCD 258  Capitella teleta
XP_013408486 1016 EKCTICLSELeedEDVRRLPCMHLFHIECVDQWLv-tNKRCPICRVD 1061 Lingula anatina
CEM03417     3311 EPCSICLTDYnkgDEVRQLPCCHFFHVTCVDQWLa-lHLDCPLCKGN 3356 Vitrella brassicaformis CCMP3155
KPL96864      192 DVCCICLERFnssITVRRLPCLHLFHCKCIDKWLn-kNRKCPICRIM 237  Sarcoptes scabiei
NP_650112    1185 EKCAICLNLFeieNEVRRLPCMHLFHTDCVDQWLv-tNKHCPICRVD 1230 fruit fly
EKX43061       27 TECCICLCEYdvgEKLRKLPCLHRFHSVCVDRWLl-sNKMCPICKES 72   Guillardia theta CCMP2712

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