Conserved Protein Domain Family
RING-HC_CARP

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cd16500: RING-HC_CARP (this model, PSSM-Id:319414 is obsolete and has been replaced by 438163)
RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins
The CARPs family includes CARP-1 and CARP-2 proteins, both of which are E3 ubiquitin ligases that ubiquitinate apical caspases and target them for proteasome-mediated degradation. As a novel group of caspase regulators with a FYVE-type zinc finger domain, they do not localize to membranes in the cell and are involved in the negative regulation of apoptosis, specifically targeting two initiator caspases, caspase 8, and caspase 10. Moreover, they stabilize MDM2 by inhibiting MDM2 self-ubiquitination, as well as by targeting 14-3-3sigma for degradation. They work together with MDM2 enhancing p53 degradation, thereby inhibiting p53-mediated cell death. CARPs contain an N-terminal FYVE-like domain that can serve as a membrane-targeting or endosome localizing signal and a C-terminal C3HC4-type RING-HC finger domain.
Statistics
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PSSM-Id: 319414
Aligned: 24 rows
Threshold Bit Score: 69.7838
Created: 3-May-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Parkin (5C1Z) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #           # #   #  #      #  #   
Q969K3       324 LCRICMDavIDCVLLECGHMVTCTKCGKRMsECPICRQY 362 human
XP_003385858 240 LCKICMDepVDCVLLECGHMLSCVKCGRKLsECPVCRQF 278 Amphimedon queenslandica
EEC07236     296 LCKICMEgcVDCVILDCGHMCTCTQCGKQLsECPICRQY 334 black-legged tick
EDO44591     255 SCKVCMDnlIDCVLLECGHMVACINCSKQLaECPICRQN 293 starlet sea anemone
EKC26254     351 LCKICMDaaINCVLLECGHMVTCTQCGRRLaECPICRQN 389 Pacific oyster
EDV21719     297 LCKICMDapITCVLLECGHMVTCTKCGKRLaECPICRQY 335 Trichoplax adhaerens
XP_002121907 294 FCKICWErpRDCVLLECAHMSTCITCGKQLrECPICRQH 332 vase tunicate
XP_009016612  96 LCKVCMEnvIDCVLLECGHMAVCKYCGKQMaECPICRKY 134 Helobdella robusta
NP_610827    652 LCKICMDapIECVFLECGHMATCTSCGKVLnECPICRQY 690 fruit fly
ELU04050     235 LCKICMDaiIDCVLLECGHMVTCTKCGRRMaECPICRQY 273 Capitella teleta

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