Conserved Protein Domain Family
RING-HC_MKRN
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cd16521: RING-HC_MKRN (this model, PSSM-Id:319435 is obsolete and has been replaced by 438184)
RING finger, HC subclass, found in the makorin (MKRN) protein family
The MKRN protein family includes the ribonucleoproteins that are characterized by a variety of zinc-finger motifs, including typical arrays of one to four C3H1-type zinc fingers and a C3HC4-type RING-HC finger. Another motif rich in Cys and His residues (CH), with so far unknown function, is also generally present in MKRN proteins. MKRN proteins may have E3 ubiquitin ligase activity.
Links
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Statistics
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PSSM-Id: 319435
Aligned: 34 rows
Threshold Bit Score: 63.875
Created: 2-May-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF144A (1WIM) binds two Zn2+ ions through its C4C4-type RING finger.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #  #                         # #  #  #                              #  # 
Q9UHC7    281 CGICMEvvyek-----anpseRRFGILSNCNHTYCLKCIRKWRsakqf-------------eskiiKSCPECR 335 human
EDO99684  168 CGICLEhvmhk------psvsDRRFGLMDCDHAFCLACIRSWRerntdas---------latdtavRTCPICR 225 Chlamydomonas reinhardtii
KGG52029  532 CGICLEplp---------vngITKFGLLNCNHPFCLECIRSWRasqnv-------------dssicRSCPICR 582 Microsporidia sp. UGP3
ETO27771  240 CGICHEniarkyesqghkdnaGRFGILTGCNHTFCLNCLREWRgsisq-------------skeaiRGCPICR 299 Reticulomyxa filosa
EKX38069  203 CGICMEtvv---------gkqSQFGLLEGCDHIFCLSCIREWRsvnil-------------eknvkRSCPLCR 253 Guillardia theta CCMP2712
EQL34362  100 CGICMEt-------------pTVFGLLVNCDHVFCLSCIRSWRssvgtsaedmintpdsrvprqttKTCPLCR 159 Ajellomyces dermatitidis ...
ELU03359  169 CCLCEEpv-----------krTLFGMLSHCNHVFCVECLRGWRcapgr-------------ehmlkRTCPKCR 217 Capitella teleta
KIO26503  119 CGICFEv-------------pGQFGLLNGCSHPFCLNCLRDWRksskkdih--------lvfsniiKTCPLCR 170 Tulasnella calospora MUT ...
NP_568885 144 CGICMEm--------------NSKVVLPNCTHSLCIKCYRDWRgr--------------------sQSCPFCR 182 thale cress
KUF86594   44 CGICFDdiv----------qsGKHFGLLHCDHCFCLDCLRSWRqskdm-------------eleviRACPACR 93  Phytophthora nicotianae

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