5DIN


Conserved Protein Domain Family
mRING-HC-C3HC3D_LNX1_like
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cd16637: mRING-HC-C3HC3D_LNX1_like (this model, PSSM-Id:319551 is obsolete and has been replaced by 438299)
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Modified RING finger, HC subclass (C3HC3D-type), found in ligand of Numb protein LNX1, LNX2, and similar proteins
The ligand of Numb protein X (LNX) family, also known as PDZ and RING (PDZRN) family, includes LNX1-5, which can interact with Numb, a key regulator of neurogenesis and neuronal differentiation. LNX5 (also known as PDZK4 or PDZRN4L) shows high sequence homology to LNX3 and LNX4, but it lacks the RING domain. LNX1-4 proteins function as E3 ubiquitin ligases and have a unique domain architecture consisting of an N-terminal RING-HC finger for E3 ubiquitin ligase activity and either two or four PDZ domains necessary for the substrate-binding. This family corresponds to LNX1/LNX2-like proteins, which contains a modified C3HC3D-type RING-HC finger and four PDZ domains.
Links
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Statistics
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PSSM-Id: 319551
Aligned: 11 rows
Threshold Bit Score: 74.6846
Created: 3-May-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding sitemodified
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:5DIN; Homo sapiens LNX2 binds two Zn2+ ions through its modified RING-HC finger.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #            # #  #  #                   #  # 
5DIN_A         30 DLVCHICLQPLLq-PLDTPCGHTFCYKCLRNFLqek---------dfCPLDR 71   human
Q8TBB1         38 DLICHICLQALLd-PLDTPCGHTYCTLCLTNFLvek---------dfCPMDR 79   human
CCD77426      243 DLCCTLCRQPLVd-PLDTKCGHTFCSPCLKNHLavq---------alCPVDK 284  Schistosoma mansoni
ELU09902       33 DLMCHICLQPLVd-PVDTKCGHTLCSLCLHNYLkiq---------smCPVDR 74   Capitella teleta
XP_011682112   42 ELTCNICLQPLVn-PMDTMCGHTFCMRCLRSVLnlh---------kfCPIDR 83   purple sea urchin
XP_013397282   58 DLICHICLQPLVn-PMDTRCGHTFCSECIKHYLkiq---------kiCPLDR 99   Lingula anatina
KDR08075       51 DLTCHICLQPFVt-PLDIPCGHTFCGACLNNYLrvq---------qlCPIDR 92   Zootermopsis nevadensis
EKC30104       60 DLMCQICLQPLVn-PLDTKCGHTYCSRCLKNYLkiq---------rqCPVDR 101  Pacific oyster
EEN44350       34 ELTCQICLQPLVn-PLDTKCGHTFCARCIRGFLkmk---------kmCPIDR 75   Florida lancelet
EDK40463       73 HLNCPICQQPFIk-PVTTICGHTFCRECIYECFrtarngdvsplkgsCPLDR 123  Meyerozyma guilliermondii ATCC 6260
EUC64290       13 NLICCICRQPFAdpTTATPCGHTFCRTCITQALdvs---------pqCPIDR 55   Rhizoctonia solani AG-3 Rhs1AP

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