2D8S


Conserved Protein Domain Family
RING_CH-C4HC3_MARCH1_like

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cd16698: RING_CH-C4HC3_MARCH1_like (this model, PSSM-Id:319612 is obsolete and has been replaced by 438359)
Click on image for an interactive view with Cn3D
RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
This family includes the closely related MARCH1 and MARCH8, both of which are located on endosomes and the plasma membrane and are implicated in regulating cell surface expression of their substrates. They ubiquitylate and downregulate many targets, including major histocompatibility complex class II (MHCII), CD86, transferrin receptor, HLA-DM, and Fas from the cell surface. MARCH1 is mainly expressed in cells of the immune system, while MARCH8 is more broadly expressed. Both of them contain an N-terminal C4HC3-type RING-CH finger, also known as vRING or RINGv, a variant of C3H2C3-type RING-H2 finger, and two transmembrane domains. The cytoplasmic RING-CH domain participates in the ubiquitin transfer from the E2 to its substrate. The transmembrane domains are implicated in target recognition and dimer formation.
Statistics
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PSSM-Id: 319612
Aligned: 11 rows
Threshold Bit Score: 95.2017
Created: 20-Mar-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-CH finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2D8S; Homo sapiens MARCH8 binds two Zn2+ ions through its RING-CH finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #                # #       #  #            #  #    
2D8S_A        17 ICRICHCEgdd---esPLITPCHCTGSLHFVHQACLQQWIKSSdtRCCELCKYEF 68  human
Q8TCQ1        79 ICRICHCEgde---esPLITPCRCTGTLRFVHQSCLHQWIKSSdtRCCELCKYDF 130 human
XP_002733112 103 ICRICHCEgdn---efPLITPCLCAGSLKYVHQQCLQHWIKSSdtKTCELCKFEL 154 Saccoglossus kowalevskii
XP_784298    146 ICRICHCEgde---emPLIYPCLCLGSLHFVHQACIQQWIKSSntKNCELCRFEF 197 purple sea urchin
ELU02250      19 LCRICHCEaev---gaPLISPCVCAGSLKYVHQRCLQQWIKSAdtKSCELCKFDF 70  Capitella teleta
KFD54429     116 ICRICHCEatn---daPLIAPCYCSGSLKFVHQRCLQQWIKSSqtKACEVCRFSF 167 pig whipworm
XP_002120897 184 ACRICHCEtdn--elgPLIAPCKCKGTLEFVHQSCLQQWIKSSdyKHCELCGFHF 236 vase tunicate
NP_648305     42 ICRICHCEsdp---qnPLLTPCYCSGSLKYVHQACLQQWLTASetNSCELCKFPF 93  fruit fly
EKC38570      65 CCRICQCEvceieddsPLIAPCLCDGSMKFVHQECLQKWIKSSdkECCELCKYEY 119 Pacific oyster
EEC12545      30 MCRICHCEada---enPLISPCYCAGSLRFVHQACLQQWIKSSdtRCCELCKFNF 81  black-legged tick
EDO37870       9 ICRICHCEaep---dqPLISPCHCSGSLQYVHQTCLQRWIKSSdtKKCELCNYEF 60  starlet sea anemone

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