Conserved Protein Domain Family
P-type_ATPase_cation
?
cd02082: P-type_ATPase_cation 
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p
Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Links
?
Statistics
?
PSSM-Id: 319777
Aligned: 3 rows
Threshold Bit Score: 1138.47
Created: 15-Dec-2004
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
Q9HD20     214 EIRAAEKKFGSNKAEMVVPDFSELFKERATAPFFVFQVFCVGLWCLDE-YWYYSVFTLSMLVAFEASLVQqqmrnms--e 290  human
Q9H7F0     183 MHAYRKLLYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSTDE-YYYYALAIVVMSIVSIVSSLYsirkqyvmlh 261  human
Q95050     145 RVDQLLAYYGKSEIEINVPSFLTLMWREFKKPINFLLYFGIIVWGIEQmYVSTAITVVFTTTINSLICIYirgvmqk--- 221  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20     291 irkmgnKPHMIQVYRs----RKWRPIASDEIVPGDIVSIgrspqENLVPCDVLLLRGRCIVDEAMLTGESVPQMKEPIed 366  human
Q9H7F0     262 dmvathSTVRVSVCRv---nEEIEEIFSTDLVPGDVMVIpl--nGTIMPCDAVLINGTCIVNESMLTGESVPVTKTNLpn 336  human
Q95050     222 lkdaclNNTSVIVQRhngqgYQEITVASNMIAPGDIVLFk---rEVTLPFDCVILEGSCQVTEANITGENVAIGKCQIpt 298  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20     367 lspdrv-----ldlqadsRLHVIFGGTKVVQhippqkattglkpvDSGCVAYVLRTGFNTSQGKLLRTILFGvKRVTANN 441  human
Q9H7F0     337 psvdvkgigdelynpethKRHTLFCGTTVIQtrf---------ytGELVKAIVVRTGFSTSKGQLVRSILYPkPTDFKLY 407  human
Q95050     299 dhhnd------ifkyessKSHTLFQGTQLMKi------------eDDILKVIVVRTGFGSYKGQIIRALLYPkPFNKKFQ 360  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20     442 LETFIFILFLLVFAIAAAAYVWIEGtkdpsrnrykLFLECTLILTSVVPPELPIELSLAVNTSLIALAKlYMYCTEPFRI 521  human
Q9H7F0     408 RDAYLFLLCLVAVAGIGFIYTIINSilnev-qvgvIIIESLDIITITVPPALPAAMTAGIVYAQRRLKKiGIFCISPQRI 486  human
Q95050     361 QQAVKLTILMATLLLIGFLSTLSRLldiel-pplfIAFRFLDILIYSAPPGMPMLIAITNFVGLKRLKNnQILGQDPNSA 439  Tetrahymena ther...

Feature 1                 #######                                                              
Q9HD20     522 PFAGKVEVCCFDKTGTLTSDSLVVRGVAGLRDGKEVtpvssi------pvethrALASCHSLmqldDGTLVGDPLEKAML 595  human
Q9H7F0     487 NICGQLNLVCFDKTGTLTEDGLDLWGIQRVENARFLspeenvcnemlvksqfvaCMATCHSLtk-iEGVLSGDPLDLKMF 565  human
Q95050     440 SQAGRIQTLCFDKTGTLTEDKVDLIGYQLKGQNQTFdkiqcqdp--nnisiehkLFSICHEVtk-iNNKLLGDLMDVKMA 516  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20     596 Tavdwtltkdekv--------------------------------fprsiktqglkIHQRFHFASALKRMSVLASyeklg 643  human
Q9H7F0     566 EaigwileeateeetalhnrimptvvrppkqllpestpagnqemelfelpatyeigIVRQFPFSSALQRMSVVARvlg-- 643  human
Q95050     517 Efstldidydheak------------------------------qhysksgnkrfyCIQVNQFHSEYQSMSVVCKevdmi 566  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20     644 stdlcYIAAVKGAPETLhsmf--sqcPPDYHHIHTEISREGARVLALGYKELghlthqqa-revkreaLECSLKFVGFIV 720  human
Q9H7F0     644 --drkMDAYMKGAPEAIaglckpetvPVDFQNVLEDFTKQGFRVIALAHRKLeskltwhkvqnisrdaIENNMDFMGLII 721  human
Q95050     567 tkefkHYFFIKGSPEKIqsl---shvQSSEKAQLSTLINEGYRILGFGYKEIpqseidaf-ldlsreqQEANVQSLGFLI 642  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20     721 VSCPLKADSKAVIREIQNASHRVVMITGDNPLTACHVAQELHFIEKAHtli--------------lqPPSEKGRQCEWRs 786  human
Q9H7F0     722 MQNKLKQETPAVLEDLHKANIRTVMVTGDSMLTAVSVARDCGMILPQDkviia----------ealpPKDGKVAKINWHy 791  human
Q95050     643 YKNNLKPDTQEVIKEFKEACYNIKVISGDNPITTLKISQELEIVNRKNptviinfeetenvkshliiTEIQPDNSTQVId 722  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20     787 idgsivlplargspkalaley---------------------------alcltgdglahlqatdpqqllrLIPHVQVFAR 839  human
Q9H7F0     792 adsltqcshpsaidpeaipvklvhdsle-------------dlqmtryhfamngksfsvilehfqdlvpkLMLHGTVFAR 858  human
Q95050     723 fssaqneqdyinkqmsyccdaflnnksfcfsgkahyyfqlkaktdhisfkpewvkmqdksvqkiisfyqmLIINTNVFAR 802  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20     840 VAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLanapervverrrrprdsptlsnsgiratsrtakqrsg 919  human
Q9H7F0     859 MAPDQKTQLIEALQNVDYFVGMCGDGANDCGALKRAHGGISLSe------------------------------------ 902  human
Q95050     803 TQPEQKQTIVRLLKESDQIVCMVGDGANDCSAIREADVGISFAe------------------------------------ 846  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20     920 lppseeqptsqrdrlsqvlrdledestpivklgDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILA 999  human
Q9H7F0     903 --------------------------------lEASVASPFTSKTPSISCVPNLIREGRAALITSFCVFKFMALYSIIQY 950  human
Q95050     847 --------------------------------aDGQFSSSYVSLSTSLSCVKRVLLEGRVNLSNSVEIFKGYLQVALLRY 894  Tetrahymena ther...

Feature 1                                                                                      
Q9HD20    1000 YSQSVLYLEgvkf------------sdfqATLQGLLLAGCFLFISRSKplktlsrerp---lpnifnlytiLTVMLQFFV 1064 human
Q9H7F0     951 FSVTLLYSIlsnlgdfqflfidlaiilvvVFTMSLNPAWKELVAQRPPs----------------------GLISGALLF 1008 human
Q95050     895 LGFLTLAYFyssy-------------ssgQMDWQALASGYFLVYLILGcntplkkleksvfddnlfsiynvTSVLFGFTL 961  Tetrahymena ther...

Feature 1                                                           
Q9HD20    1065 HFLSLVYLYREAQARspekqeqfvdlykeFEPSLVNSTVYIMAMAMQMATFAI 1117 human
Q9H7F0    1009 SVLSQIIICIGFQSLgf----------fwVKQQPWYEVWHPKSDACNTTGSGF 1051 human
Q95050     962 HILSIVGCVESLHASpiyke----vnsldAENNFQFETQHNTVLNFNILINFF 1010 Tetrahymena thermophila

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap