1RJV,5PAL


Conserved Protein Domain Family
EFh_parvalbumin_alpha

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cd16254: EFh_parvalbumin_alpha 
Click on image for an interactive view with Cn3D
EF-hand, calcium binding motif, found in alpha-parvalbumin
Alpha-parvalbumin is cytosolic Ca2+/Mg2+-binding protein expressed mainly in fast-twitch skeletal myofibrils, where it may act as a soluble relaxing factor facilitating the Ca2+-mediated relaxation phase. It is also expressed in rapidly firing neurons, particularly GABA-ergic neurons, and thus may confer protection against Ca2+ toxicity. The major role of alpha-parvalbumin is metal buffering and transport of Ca2+. It binds different metal cations, and exhibits very high affinity for Ca2+ and physiologically significant affinity for Mg2+. Alpha-parvalbumin is characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix) called AB, CD, and EF, but only CD and EF can chelate metal ions, such as Ca2+ and Mg2+. Both metal ion-binding sites in alpha-parvalbumin are high-affinity sites. Additionally, in contrast to beta-parvalbumin, alpha-parvalbumin is less acidic and has an additional residue in the C-terminal helix.
Statistics
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PSSM-Id: 319997
View PSSM: cd16254
Aligned: 6 rows
Threshold Bit Score: 144.966
Threshold Setting Gi: 62511042
Created: 19-Nov-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                   # # #   #  #                         
1RJV_A         9 AEDIKKAVGAFSATDSFDHKKFFQMVGLKKksadDVKKVFHMLDKDKSGFIEEDELGFILKGFSpdardlsakETKMLMA 88  human
5PAL_A         8 ADDINKAISAFKDPGTFDYKRFFHLVGLKGktdaQVKEVFEILDKDQSGFIEEEELKGVLKGFSahgrdlndtETKALLA 87  leopard shark
XP_007421084  42 DEEIKKMLRAFAATNSFDYKKFFEMLGLKNkslqELNMFFSILDTDKNGYLEPDEIQLMLQDFSpnsrhltdkETQEFMG 121 Burmese python
NP_001152787   9 AEDIKKAVGAFSAAESFNYKKFFEMVGLKKkspeDVKKVFHILDKDRSGFIEEEELKFVLKGFTpdgrdlsdkETKALLA 88  chicken
NP_001087327   9 AADIKNAVGAFAAADSFNHKKFFELVGLKKksvdDVKKVFHILDQDRSGFIEEDELKLVLKGFTpdgralsdkETKTLLA 88  African clawed ...
Q804W2         9 DDDIKKALDQFKAADSFDHKKFFDVVGLKAlsadNVKLVFKALDVDASGFIEEEELKFVLKGFSadgrdltdkETKAFLA 88  zebrafish
Feature 1          # # #      #       
1RJV_A        89 AGDKDGDGKIGVDEFSTLVAE 109 human
5PAL_A        88 AGDSDHDGKIGADEFAKMVAQ 108 leopard shark
XP_007421084 122 AGDKDEDGKIGIDEFIILVNQ 142 Burmese python
NP_001152787  89 AGDKDGDGKIGADEFATMVAE 109 chicken
NP_001087327  89 AGDKDGDGKIGVDEFTTLVAE 109 African clawed frog
Q804W2        89 AADKDGDGKIGIDEFEALVHE 109 zebrafish

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