Conserved Protein Domain Family
EFh_DTNB

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cd16250: EFh_DTNB 
EF-hand-like motif found in beta-dystrobrevin
Beta-dystrobrevin, also termed dystrobrevin beta (DTN-B), is a dystrophin-related protein that is restricted to non-muscle tissues and is abundantly expressed in brain, lung, kidney, and liver. It may be involved in regulating chromatin dynamics, possibly playing a role in neuronal differentiation, through the interactions with the high mobility group HMG20 proteins iBRAF/HMG20a and BRAF35 /HMG20b. It also binds to and represses the promoter of synapsin I, a neuronal differentiation gene. Moreover, beta-dystrobrevin functions as a kinesin-binding receptor involved in brain development via the association with the extracellular matrix components pancortins. Furthermore, beta-dystrobrevin binds directly to dystrophin and is a cytoplasmic component of the dystrophin-associated glycoprotein complex, a multimeric protein complex that links the extracellular matrix to the cortical actin cytoskeleton and acts as a scaffold for signaling proteins such as protein kinase A. Absence of alpha- and beta-dystrobrevin causes cerebellar synaptic defects and abnormal motor behavior. Beta-dystrobrevin has a compact cluster of domains comprising four EF-hand-like motifs and a ZZ-domain, followed by a looser region with two coiled-coils. These domains are believed to be involved in protein-protein interactions. In addition, beta-dystrobrevin contain two syntrophin binding sites (SBSs).
Statistics
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PSSM-Id: 320008
Aligned: 3 rows
Threshold Bit Score: 328.138
Created: 12-Nov-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:EF-hand-like motif [structural motif]
Evidence:
  • Comment:The EF-like motifs don't contain the canonical pattern of calcium binding residues.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ##########################################                                      
O60941        54 DIWNMIEAFRDNGLNTLDHTTEISVSRLETVISSIYYQLNKRlpsthqisVEQSISLLLNFMIAAYDSEGRGKLTVFSVK 133 human
XP_007062871  54 DIWNMIEAFRDNGLNTLDHNTEISVSRLETIISSIYYQLNKRlpsthqisVEQSISLLLNFMIAAYDSEGHGKLTVFSVK 133 green sea turtle
XP_007898639  72 DIWNMIEAFRDNGLNTLDHSTEINVSRLETIISSIYYQLNKRlptthqisVEQSISLLLNFMIAAYDSEGHGKLTVFSVK 151 elephant shark
Feature 1                                                                                        
O60941       134 AMLATmcggkMLDKLRYVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAvfegpsfgytEHSVRTCFPQQRKIMLNMFLDTM 213 human
XP_007062871 134 AMLATmcggkIQDKLRYIFSQMSDSNGLMIFTKFDQFLREVLKLPTAvfegpsfgytEHSVRTCFPQQKKIMLNMFLDTL 213 green sea turtle
XP_007898639 152 AMLATmcggkILDKLRYTFSQISDSNGMMVYLKFDQFLREVLKLPTAvfegpsfgytEHAVRTCFPQQKKVTLNMFLDTM 231 elephant shark
Feature 1         
O60941       214 M 214 human
XP_007062871 214 M 214 green sea turtle
XP_007898639 232 L 232 elephant shark

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