Conserved Protein Domain Family
7tmA_OR

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cd13954: 7tmA_OR 
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320092
View PSSM: cd13954
Aligned: 116 rows
Threshold Bit Score: 257.027
Threshold Setting Gi: 38372712
Created: 23-Dec-2011
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
P23275        25 IIFFAVILASYLLTLVGNLTIILLSRLDARlhtpMYFFLSNLSSLDLAFTTSSVPQMLKNLwgpdKTISyggCVTQLYVF 104 house mouse
Q8NGF8        23 SVCFVVFLPVYLATVVGNGLIVLTVSISKSldspMYFFLSCLSLVEISYSSTIAPKFIIDLlakiKTISlegCLTQIFFF 102 human
Q9GZK7        27 FLFFIVFTAVYVFIIIGNMLIIVAVVSSQRlhkpMYIFLANLSFLDILYTSAVMPKMLEGFlq-eATISvagCLLQFFIF 105 human
Q8NGC1        63 ILLFVLFTVVYLLTLMGNGSIICAVHWDQRlhapMYILLANFSFLEICYVTSTVPSMLANFlsdtKIISfsgCFLQFYFF 142 human
Q9UGF7        23 PFFFGIFLIIYLINLIGNGSILVMVVLEPQlhspMYFFLGNLSCLDISYSSVTLPKLLVNLvcsrRAISflgCITQLHFF 102 human
Q8NH80        25 MTLFVLFLPFYACTLLGNVSILVAVMSSARlhtpMYFFLGNLSVFDMGFSSVTCPKMLLYLmglsRLISykdCVCQLFFF 104 human
Q8NH81        46 APLFLAFLVIYLLTVSGNGLIILTVLVDIRlhrpMCLFLCHLSFLDMTISCAIVPKMLAGFllgsRIISfggCVIQLFSF 125 human
A6NND4        30 LPVFFIFLLFYLLILMGNALILVAVVAEPSlhkpMYFFLINLSTLDILFTTTTVPKMLSLFllgdRFLSfssCLLQMYLF 109 human
XP_006009371  27 RFLFPFFLAAYLVTLTGNMLILIAVKTSHKlhtpMYFFLANLSVIDILYTTTTLPKMLSKLllddKVISftgCFLQMFFF 106 coelacanth
XP_006009373  27 LLLFVFFLTVYLVTLTGNMLILIATRTSHKlhtpMYFFLANLSVLDILYTTTTLPKMLSKLllsdKTISftgCFLQMYFF 106 coelacanth
Feature 1        #  #                                            # #####                         
P23275       105 LWLGaTECILLVVMAFDRYVAVCRPlhYMTVMnPRLCWGLAAISWLGGLGNSVIQstftlqLPFCGhrkVDNFlCEVPAM 184 house mouse
Q8NGF8       103 HFFGvAEILLIVVMAYDCYVAICKPlhYMNIIsRQLCHLLVAGSWLGGFCHSIIQilviiqLPFCGpnvIDHYfCDLQPL 182 human
Q9GZK7       106 GSLAtAECLLLAVMAYDRYLAICYPlhYPLLMgPRRYMGLVVTTWLSGFVVDGLVvalvaqLRFCGpnhIDQFyCDFMLF 185 human
Q8NGC1       143 FSLGsTECFFLAVMAFDRYLAICRPlrYPTIMtRRLCTNLVVNCWVLGFIWFLIPivnisqMSFCGsriIDHFlCDPAPL 222 human
Q9UGF7       103 HFLGsTEAILLAIMAFDRFVAICNPlrYTVIMnPQVCILLAAAAWLISFFYALMHsvmtahLSFCGsqkLNHFfYDVKPL 182 human
Q8NH80       105 HFLGsIECFLFTVMAYDRFTAICYPlrYTVIMnPRICVALAVGTWLLGCIHSSILtsltftLPYCGpneVDHFfCDIPAL 184 human
Q8NH81       126 HFLGcTECFLYTLMAYDRFLAICKPlhYATIMtHRVCNSLALGTWLGGTIHSLFQtsfvfrLPFCGpnrVDYIfCDIPAM 205 human
A6NND4       110 QSFTcSEAFILVVMAYDRYVAICHPlhYPVLMnPQTNATLAASAWLTALLLPIPAvvrtsqMAYNSiayIYHCfCDHLAV 189 human
XP_006009371 107 LSFGtIECFTLVVMAYDRYVAICDPlrYNTKItKEVCILLAASAWVLGFALIFPAviltaqLPYCGpnsVYHCfCDHSAV 186 coelacanth
XP_006009373 107 LSLQtVECLILAVMAYDRYVAICDPlrYNSKMtKQVYILFAATAWLLGFVFPSPTvilalwLPYCGpntVNHClCDHSSV 186 coelacanth
Feature 1                  #  ### ### ##                                             #  ## ##  # 
P23275       185 IKLACgdtslNEAVLNGVCTFFTVVPVSVILVSYCFIAQAVmki-rsvEGRRKAFNTCVSHLVVVFLFYGSAIYGYLLPa 263 house mouse
Q8NGF8       183 FKLACtdtfmEGVIVLANSGLFSVFSFLILVSSYIVILVNLrnh--saEGRHKALSTCASHITVVILFFGPAIFLYMRPs 260 human
Q9GZK7       186 VGLACsdprvAQVTTLILSVFCLTIPFGLILTSYARIVVAVlrv-pagASRRRAFSTCSSHLAVVTTFYGTLMIFYVAPs 264 human
Q8NGC1       223 LTLTCkkgpvIELVFSVLSPLPVFMLFLFIVGSYALVVRAVlrv-psaAGRRKAFSTCGSHLAVVSLFYGSVLVMYGSPp 301 human
Q9UGF7       183 LELACsdtllNQWLLSIVTGSISMGAFFLTLLSCFYVIGFLlfknrscRILHKALSTCASHFMVVCLFYGPVGFTYIRPa 262 human
Q8NH80       185 LPLACadtslAQRVSFTNVGLISLVCFLLILLSYTRITISIlsi-rttEGRRRAFSTCSAHLIAILCAYGPIITVYLQPt 263 human
Q8NH81       206 LRLACadtaiNELVTFADIGFLALTCFMLILTSYGYIVAAIlri-psaDGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPc 284 human
A6NND4       190 VQASCsdttpQTLMGFCIAMVVSFLPLLLVLLSYVHILASVlri-sslEGRAKAFSTCSSHLLVVGTYYSSIAIAYVAYr 268 human
XP_006009371 187 LKLACtdtivNNILGLSIALTVLVIPCILILVSYVKIIISVlki-asgEGRRKAFSTCVSHLIVVIIFFSSACFTYISFr 265 coelacanth
XP_006009373 187 LKLACtntivNNMLGLSIALAVLLIPCILILVSYVKILTSVlki-asgEGRRKAFSTCVSHLIVVSIFFLSACFTYISYr 265 coelacanth
Feature 1             ## ###  #  ##              
P23275       264 k-ssNQSQGKFISLFYSVVTPMVNPLIYTLRN 294 house mouse
Q8NGF8       261 ---sTFTEDKLVAVFYTVITPMLNPIIYTLRN 289 human
Q9GZK7       265 a-vhSQLLSKVFSLLYTVVTPLFNPVIYTMRN 295 human
Q8NGC1       302 s-knEAGKQKTVTLFYSVVTPLLNPVIYSLRN 332 human
Q9UGF7       263 s-atSMIQDRIMAIMYSAVTPVLNPLIYTLRN 293 human
Q8NH80       264 ---pNPMLGTVVQILMNLVGPMLNPLIYTLRN 292 human
Q8NH81       285 ---sQEPLDGVVAVFYTVITPLLNSIIYTLCN 313 human
A6NND4       269 a-dlPLDFHIMGNVVYAILTPILNPLIYTLRN 299 human
XP_006009371 266 ipsvTVDFRIMCVVLYAFLTPMLNPIIYCLRN 297 coelacanth
XP_006009373 266 ipsvTMDFRIMCVVLYAVLTPMLNPIIYCLRN 297 coelacanth

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