2KS9


Conserved Protein Domain Family
7tmA_TACR_family

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cd14992: 7tmA_TACR_family 
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tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.
Statistics
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PSSM-Id: 320123
View PSSM: cd14992
Aligned: 5 rows
Threshold Bit Score: 347.498
Threshold Setting Gi: 310942510
Created: 30-Sep-2008
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
2KS9_A     33 VLWAAAYTVIVVTSVVGNVVVMWIILAHKRmr-------------------------------tvTNYFLVNLAFAEASM 81  human
ACM69153   67 IVIGVALVGIMLVCGIGNFIFIAALARYKKlr-------------------------------nlTNLLIANLAISDFIV 115 chicken
EKC19158   26 SILMVLYSVIIFVSLVGNMLVLITVCGNRNmr-------------------------------svTNVFILSLSVSDLLL 74  Pacific oyster
ELT87230   18 NILTVLHCIVITFAVVGNIGVIVVFAKNKSfr-------------------------------gaVTIPILSLAIGNLLM 66  Capitella sp. I Gr...
CCD82074  105 PHSENYLQSFKNRHVDGNYSSSASDYDHNNllkknldnsiekapkhlhhimrntcqkqtfymngaFNYYLASLGISDLFM 184 Schistosoma mansoni
Feature 1            #  ##                ###### ##  #                                        
2KS9_A     82 AAFNTVVNFTYAvh--neWYYGlf---yCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPlqpr-----lsaTATKVVI 151 human
ACM69153  116 AIVCCPFEMDYYvvrqlsWEHGhv---lCASVNYLRTVSLYVSTNALLAIAVDRYLAIVHPlkpr-----mnyQTATILI 187 chicken
EKC19158   75 ALIATPINMGNVms--tyWKYGaf---aCKIVPCITTFCVACSSLTLCCIAFERFYAIVYPlkvkf---fqasTRLVPLL 146 Pacific oyster
ELT87230   67 ALLCLPFSLILVls--rsLEMNsfsefvCKLVPYMETTTIVSNALTMGGIAMERYFATLHPlksrs---iqstTKTVLIL 141 Capitella sp. I Gr...
CCD82074  185 GLFCIPFTFTQIyl--hhWPFPdl---mCPIVVYVQLVMVTASSLTNTVISLNRLFGIISPfrfdhwpsrhqkSLTICII 259 Schistosoma mansoni
Feature 1            # #####                                       #  ### ### ##              
2KS9_A    152 CVIWVLALLLAFPQGYYsttetmpsrvvc------------miewpehpnkiyEKVYHICVTVLIYFLPLLVIGYAYTVV 219 human
ACM69153  188 ALVWIVSILVAIPSAYFatetvlfivknqek--------ifcgqiwpvdqqmyYKSYFLFIFGIEFVAPVITMTLCYARI 259 chicken
EKC19158  147 ITVWVTSLISGTPQVFYfklikardvcgkvv--------ndvctlplitsktmEFFQLWLPFVVLFVTPLLVMTILYSII 218 Pacific oyster
ELT87230  142 TTIWMVAVCLAIPNLLWhslepilsadilng---------pyqgfcspsnhtaMTVYRLLILVGIFGLSFIAITVAYVQI 212 Capitella sp. I Gr...
CCD82074  260 ISIWAISFSGSTVQLFAtrtqrqgqntnpleqkegysagrklcqeswdgddykRSIYTVVLFLVIYIIPLGIQTSTYGYI 339 Schistosoma mansoni
Feature 1                                               #  ## ##  #             ## ###  #  ## 
2KS9_A    220 GITLwaseipgds-sdryheqvSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPyinpdl--ylkkfIQQVYLAIMWLAMS 296 human
ACM69153  260 SRELwfktvpgfq-teqirkrlRCRRKTVMVLMCILTAYVLCWAPFYGFTIVRdffpti-fvkekhYLTAFYIVECIAMS 337 chicken
EKC19158  219 IVKLwgrrqigismkasdsyrlKQKKRAIKMLVTVVVLFIICWLPIQTFNAVGekasn---mtpvaTLQWKAFLKCLALS 295 Pacific oyster
ELT87230  213 NRHLnkrkspgnsqcpvellhmKTSRRVISMLVAVQVLFFICWAPFLLFQAIApvlkl---eitpgNLNLYYFLHWWAAC 289 Capitella sp. I Gr...
CCD82074  340 SFRLwnrktpgesikgvedmriKEKKRIIKMLAFIVAMFGICWLPSHLFFLLQdfstlfrnmpehtTRLVYGMCHWIAMS 419 Schistosoma mansoni
Feature 1                         
2KS9_A    297 STMYNPIIYCCLNdrFRLGF 316 human
ACM69153  338 NSMINTMCFVTVKnnTMKYF 357 chicken
EKC19158  296 SSCYNPIVYAFMNenFRKNF 315 Pacific oyster
ELT87230  290 NCCQNPIVYTLLHpkFRRNF 309 Capitella sp. I Grassle & Grassle, 1976
CCD82074  420 NSFVNPIIYLIMSrsFRSIR 439 Schistosoma mansoni

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