Conserved Protein Domain Family
7tmA_GPRnna14-like

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cd15001: 7tmA_GPRnna14-like 
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320132
Aligned: 16 rows
Threshold Bit Score: 283.398
Threshold Setting Gi: 443687887
Created: 6-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                            #  ##                    
EEB19397   34 EIIIIHVIIFVFGVFGNVIVIVVMAGDRKfrsaTNFFLVSLAFGDLLMLCVYGPLETYTHfvikwd-------------- 99  human body louse
EEN45663    6 PTILTYAVCFLLGTVGNVLVIFSVARFRRlrstTNYLLGNLATADLLIVALCVPVKAAEFflpswq-------------- 71  Florida lancelet
EEN58738    7 PTILTYGITFVVGTLGNALVLFCTVRYKRlraaTTYYLASLAAADLIICFACVPIRTAEYflpqwe-------------- 72  Florida lancelet
EEN58609    7 PVLTVATLTVLLGTTGNVLVIFSVCRYRRlrssISFYLVSLATADLFLCCVFTPLKTAEYflpewp-------------- 72  Florida lancelet
NP_497057  74 LPGFLYLTVFLVGTIGNSMVIFVVNRFKRmrnvTNIFLASLSTADLCLIWFCVPIMFMKYmshtws-------------- 139 nematode
ELU11863  101 IFVITYSLVMVVGLLGNSMVLVTIGKFLGtksvTNTFIASLACADLLVIMICLPFQINYVwrggwa-------------- 166 Capitella sp. I Gr...
EEN43289   37 PTLVVGAVIFIVGVAGNSVVVASVLRFRQr--gIYFYLLSLSLADLLVLLFGLPMKIAEWfflsew-------------- 100 Florida lancelet
EFV54231   53 PLGIWYGLVLILGAIGNSLVITVVIRYRKmrsfTNILLSSMSTADLLILLFCLPVQVDLNfsiifkfihfsslplqycky 132 Trichinella spiralis
XP_789888  54 PVFAVYAITFLVGMTGNLLVIFAVVKSRRlhnvTCFFLANLAVADLLTVVFLIPLQIIVHssdhwn-------------- 119 purple sea urchin
ELU06396  123 PYISAYLALSVLGMIGNVIILLAVTLCIPrpsvINVMITSLAIADLFVLAFCAPFQTYATgwstwg-------------- 188 Capitella sp. I Gr...
Feature 1                ###### ##  #                                            # #####      
EEB19397  100 ------etgaiCKTAKFAELVSATSSVLNLLAVTLERFIVIVFPMKsqtfctvsNMIKAVLSVWLLSLIFAFPVVLTtst 173 human body louse
EEN45663   72 ------lggflCKATALLQFLSVICSVLTLTCISIERYYGILHPMKartmfmygKARRAVVLIWVLSFLLASPSLAVqgl 145 Florida lancelet
EEN58738   73 ------lglfmCKAIAYVQMSSVVCSVLTLTAISIERYYAILHPMKaksictlgRTRKIMAGVWIMALILSSPILYGqtv 146 Florida lancelet
EEN58609   73 ------fgpvmCKAVAYIQLLSMSSSVLTLTAIAYERNYIIVYPMKaksactmsRTRRVIALIWITSLILSAPVLYGqql 146 Florida lancelet
NP_497057 140 ------mgrfaCYSVHYIQQFTCFCSVLTMTMISFERFLAIAYPMRniwfssigRAKKVILLIWMSSAVLAVPTAVRmdy 213 nematode
ELU11863  167 ------agkyaCYVVIYLYYASYIASCLTLTAMSIERWLAICFPMRaqyasssgRARKTALLVWVISFALAVPAIFVvit 240 Capitella sp. I Gr...
EEN43289  101 -----vlgtamCKILAYLQLLSFTASVMTLTATAIERKFVILNPVKartqqvrrRACRALLLVWGISLILSSPILFPvtt 175 Florida lancelet
EFV54231  133 lshswimgaflCVAFHYVELMTMICSLMTMTTISIQRYAAVAFPMKsmsfrskkRALKTVLVTWLFSALLAVPILFGqel 212 Trichinella spiralis
XP_789888 120 ------lgdvmCRLVAYVGVISPVCSVFTMMIISLERYYVVLHPLQarsfvtmgRAKRVITALWLASCIFSSPAIFSkkv 193 purple sea urchin
ELU06396  189 ------lgaevCKIMWYFYYACFGISVFTMVVMAFERYLVICHPMKaqiwssvgRAKKTAAGIWLLGAITAIPAAFAyvs 262 Capitella sp. I Gr...
Feature 1                                     #  ### ### ##                                   
EEB19397  174 yqitftnnvt----------sltlnyctnsgdSPDFVVYQFFIIFFIPSITMTVCYSLv--------------------- 222 human body louse
EEN45663  146 vkfdwgtgdt---------iyhcqqvwssvvyERLYVLYGLAVLFVLPLAIMVFSYGCvireivqrrrgqm--------- 207 Florida lancelet
EEN58738  147 rgypisaevt---------vyhcqpswpsvvyHQVYIVYGALVIFLLPFIVMVRPVVLvtfalfnggrwvqiftsipltk 217 Florida lancelet
EEN58609  147 qrydwpvyta----------yhcqkgwpgplySRLYAIYVAIFLFFIPVIVMVAAYGRasfelwasee------------ 204 Florida lancelet
NP_497057 214 etnlslsgqrvhwc--rrrfpaqflgyprtslNKAYAMYQLLLLIIFPVLTMSICYARvsaivyksskdrvilsqamvaf 291 nematode
ELU11863  241 erdscl------------------irirqtplLRFFTVYVGAVIFFIPLIVMATAYTHtaitlwksiktnrem------- 295 Capitella sp. I Gr...
EEN43289  176 vpfegedger---------qwhcahawpsplyGRLYAVYNAVVLLMVPLCVMTYTYIRsghevlaarkggyrgnksrrkg 246 Florida lancelet
EFV54231  213 evyktpknvt---------vswcwrrfsdhywEKIFVLYQFVILYLGPFATTAISYLLliqrlyfgeansllqenvsars 283 Trichinella spiralis
XP_789888 194 tahyweeelep-------ysytcnnawpseamSIIYSVYLFLLLFFVPLLIVSYAYMRiachlnstrerssgesngspfn 266 purple sea urchin
ELU06396  263 vllierratpfliiqghssgestcgilwmgsyVLYLMSYLAIAIFGVPTVVMTAAYIRigatlyksiavrr--------- 333 Capitella sp. I Gr...
Feature 1                                                                                     
EEB19397  223 -------------------------------------------------------------------------IRELWVI 229 human body louse
EEN45663  208 -------------------------------------------------------------seskheenavpgDNKGWII 226 Florida lancelet
EEN58738  218 ksgsesrtltvahrgwga----------------tqviwflrcyscvsptlcpgdflnlmcalitsiestyfgLTWFQLI 281 Florida lancelet
EEN58609  205 ----------------------------------------------------------------vqctcgmfnRHKAAVM 220 Florida lancelet
NP_497057 292 skaatdavtfsg----------------------------ysaipmittsrnlktanttiksysnhrnnrvaeANKKQIV 343 nematode
ELU11863  296 -----------------------------------------------------------natakqangkgdagSERLKVI 316 Capitella sp. I Gr...
EEN43289  247 wnicw-----------------------------------------vkclrkirnrrdstdpdsdnvlsahgrGNPLKVI 285 Florida lancelet
EFV54231  284 agn---------------------------------------------angstaehqqtcqakssqkrfcprrEQSKKVT 318 Trichinella spiralis
XP_789888 267 rpvlsryrvwyrntsgwssgssfvrraeaasqangvtidddtteadalrsepsrvenlndspaprrhrgtsegDKIQRVI 346 purple sea urchin
ELU06396  334 ------------------------------------------------------------klkhsegkdsessDDRIQVI 353 Capitella sp. I Gr...
Feature 1                  #  ## ##  #                ## ###  #  ##                     
EEB19397  230 KMLILVIILFYLCWGPRVCMDMLQkfnfi------pfnqsVYKMRIIFNVMTFFHGCINPFIYSFMSkNFRGRL 297 human body louse
EEN45663  227 KMLLVVMAVFVCCWGPLLIRHTLVtfdlld-----ehtqlMYALRITFHLLSYLNSCANPVCYAFMSrSFRISF 295 Florida lancelet
EEN58738  282 KMLIVVIALFAVCWVPILLLNVLKafdvvn-----tytpeVYYMSIAFQLMGYLNSCVNPICYAFMSkNFRQVC 350 Florida lancelet
EEN58609  221 KMLLMVVFLYTMCWAPILLLNMLIefsain-----kntqlVWALQATFELLVYINSCVNPICYAFMSrHFRDGF 289 Florida lancelet
NP_497057 344 QMLISIVCMYTVCWLPTIVDELLTsfgyicr---tsntqtLKHMRMGFNALTYCQSCINPILYAFISqNFRSTF 414 nematode
ELU11863  317 QMLISVLVIFAFCWTPNLVMDIAEsfgygil--pglsaknQRYIDRAFACLTFANSCLNPLLYAFLSlQFRTGF 388 Capitella sp. I Grassle ...
EEN43289  286 KLMAGLVLVFTMCWAPLLIYNLLVkfevis-----rytqaAYILKLALHLLAYSNSCVNPVCYAFLSrHFRSRS 354 Florida lancelet
EFV54231  319 KMLVIILLLFFVCWTPTLVDEFLVafdylch---tsptttLKYMRMIFAIMKFSNSCINPIVYAFMSnSFRTTF 389 Trichinella spiralis
XP_789888 347 TMLAIVVALFILSWGPLLTYTLIYrfidd------mpyntHAVLSLFLHLLAACNSCVNPIIYAFLSkNFRQSF 414 purple sea urchin
ELU06396  354 RLLMSMLVLFVLCWGPNFIATVFWlanedqrlfgalnfeqGKSVVQGLTILSYANSMLNPFLYMLTSkQYRGAV 427 Capitella sp. I Grassle ...

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