Conserved Protein Domain Family
7tmA_SREB-like

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cd15005: 7tmA_SREB-like 
super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320134
View PSSM: cd15005
Aligned: 7 rows
Threshold Bit Score: 432.266
Threshold Setting Gi: 15214047
Created: 25-Sep-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##               ####
Q9NS67        19 GLKLATLSLLLCVSLAGNVLFALLIVRERSlhraPYYLLLDLCLADGLRALACLPAVMLAArraaaaagAPPGalgCKLL 98  human
P60895        21 FLKLTSLGFIIGVSVVGNLLISILLVKDKTlhraPYYFLLDLCCSDILRSAICFPFVFNSVkng---stWTYGtltCKVI 97  horse
ACY92528      51 VFKTFTLIVIIAVSVCGNGIMCFIVVRDKSlhrpPFYFLLNIALADMLRALHCLSFTASAVsh----hgWIYGkavCQVI 126 Saccoglossus ko...
EKC24819      74 ALYVTALTCVLLFGFLGNLLVVVTIARNATfhraPFFFLLNLSISDLCRCLFCVPFVIASVvqd---vgWIHGevsCIVI 150 Pacific oyster
Q9NS66        23 YVKLVLLGLIMCVSLAGNAILSLLVLKERAlhkaPYYFLLDLCLADGIRSAVCFPFVLASVrhg---ssWTFSalsCKIV 99  rhesus monkey
AAI55841      23 AVKLASLGLITCISLLGNSVLSVLVLKDSSlhkaPYYFLLDLCVADIIRSAVCFPFVMISInsg---svWSYSyisCKII 99  zebrafish
XP_003642076  26 GLKLATLGLILCVSLAGNVLFAWLILKDRHlhraPYYLLLDLCLADGLRSLACFPFVMLSVrsg---aaWPHGllsCKVL 102 chicken
Feature 1        ## ##  #                                             # #####                    
Q9NS67        99 AFLAALFCFHAAFLLLGVGVTRYLAIAhhrFYAERLagwpCAAMLVCAAWALALAAAFPPVLdg---ggDDEDAPCALEQ 175 human
P60895        98 AFLGVLSCFHTAFMLFCISVTRYLAIAhhrFYTKRLtf-wTCLAVICMVWTLSVAMAFPPVLdvgtysfIREEDQCTFQH 176 horse
ACY92528     127 AFFNVLLTFGSVFTLFVLAISRYAVFRyhkFHRLKMsf-lACLLVILVAWALAIVMAFPPVFglgsytyIPREYQCNYDH 205 Saccoglossus ko...
EKC24819     151 AFTNFFFVFNSFITILVIAIDRYVSVAypyIHKRWLlqgpTSLVLVAIGWFLSGLVSLPPVFgdrsytfVEEENQCTFQH 230 Pacific oyster
Q9NS66       100 AFMAVLFCFHAAFMLFCISVTRYMAIAhhrFYAKRMtl-wTCAAVICMAWTLSVAMAFPPVFdvgtykfIREEDQCIFEH 178 rhesus monkey
AAI55841     100 AFMAVLFCFHIAFLLFCVSVTRYMAIAhhrFYSKRMtl-wTCVAVICMVWTLSVAMAFPPVFdvgtykfIREEEQCIFEH 178 zebrafish
XP_003642076 103 AFLAVLFCFHAAFLLFCVGVTRYMAIAhhrFYAKRMtg-wTCLAVVCMVWTLSMAMAFPPVFdvgtykfIREEEQCIFEH 181 chicken
Feature 1          #  ### ### ##                                                                 
Q9NS67       176 RpDGAPGALGFLLLLAVVVGATHLVYLRLLFFihdrRKMRPARLVPAVSHDWTFHGPGATGQAAANWtagfgrgptppal 255 human
P60895       177 RsFRANDSLGFMLLLALILLATQLVYLKLIFFvhdrRKMKPVQFVAAVSQNWTFHGPGASGQAAANWlagfgrgptpptl 256 horse
ACY92528     206 RfYKSNDTLGFILVLVISIILTHLMYLKSLIFlrhhRKMTPINFVPASSNNWTFYGPGATGRAAANWvtgfaglgppppt 285 Saccoglossus ko...
EKC24819     231 TsYKHNDTFGFLLVLTAVQFGSFFIYCRIFIFlrhhRRMKPLENPPSMSSNWTFAGPGLQNMFPMAWnglplhpiptitq 310 Pacific oyster
Q9NS66       179 RyFKANDTLGFMLMLAVLMAATHAVYGKLLLFeyrhRKMKPVQMVPAISQNWTFHGPGATGQAAANWiagfgrgpmpptl 258 rhesus monkey
AAI55841     179 RyVKANDTLGFMLMLAVIVATTHVVYVKMLCFvydhRKMKPAQLVPAISQNWTFHGPGATGQAAANWiagfgrgptpptl 258 zebrafish
XP_003642076 182 RyVKANDTLGFMLMLAAVIAATHLVYIKLLFFihghRKMKPAQLVPAISQNWTFHGPGATGQAAANWtagfgrgptpptl 261 chicken
Feature 1                                                 #  ## ##  #        ## ###  #  ##       
Q9NS67       256 vgirpagpgrgarrllvleefKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLvrpgavPQAYLTASVWLTFAQAGINP 335 human
P60895       257 lgirqnanttgrrrllvldefKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFargpvvPGGFLTAAVWMSFAQAGINP 336 horse
ACY92528     286 lv----gfsqyarrshlhahfKRESETTRTTYIITLAFLVLWLPYIIYNYIIIFvrdynfSEQFVAMATWMTYLQVCVNP 361 Saccoglossus ko...
EKC24819     311 n-------lssasgqidrirhRKNEHLTRLFFAVTLCVYLLWSLYCIQSLVLIFsdt-viPKGFRRITTLATFLQVCVSP 382 Pacific oyster
Q9NS66       259 lgir-qnghaasrrllgmdevKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFvkacavPHRYLATAVWMSFAQAAVNP 337 rhesus monkey
AAI55841     259 vgir-qaahnanrrllvldefKMEKRIGKMYYMITLAFLLFWAPYIVSCYIRVFvkgnalPQVYLSAAVWLTFAQAGANP 337 zebrafish
XP_003642076 262 vgir-qathsqikrllvleefKMEKRLCKMFYMITLLFLLLWSPYIVACYLRVFikassiPQVYLTTSVWMTFAQAGVNP 340 chicken
Feature 1                      
Q9NS67       336 VVCFLFNRELRDCF 349 human
P60895       337 FVCIFSNRELRRCF 350 horse
ACY92528     362 IICFCCNRNLRKSL 375 Saccoglossus kowalevskii
EKC24819     383 VTFTFHFRKIVINN 396 Pacific oyster
Q9NS66       338 IVCFLLNKDLKKCL 351 rhesus monkey
AAI55841     338 IICFIFNKELRMRF 351 zebrafish
XP_003642076 341 ILCFIFNKELRVCL 354 chicken

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